Search Results - "M. Batchelor, Andrew"

Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors by Batchelor, Andrew M., Bartus, Katalin, Reynell, Clare, Constantinou, Sophie, Halvey, Edward J., Held, Kara F., Dostmann, Wolfgang R., Vernon, Jeffrey, Garthwaite, John, Ignarro, Louis J.

“…Nitric oxide (NO) functions as a diffusible transmitter in most tissues of the body and exerts its effects by binding to receptors harboring a guanylyl cyclase…”
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Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging by Bhargava, Yogesh, Hampden-Smith, Kathryn, Chachlaki, Konstantina, Wood, Katherine C, Vernon, Jeffrey, Allerston, Charles K, Batchelor, Andrew M, Garthwaite, John

“…Genetically-encoded biosensors are powerful tools for understanding cellular signal transduction mechanisms. In aiming to investigate cGMP signaling in…”
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Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway by Batchelor, Andrew M, Garthwaite, John

“…In the classical view, a central neuron integrates incoming synaptic information by simple algebraic summation of the resultant bioelectrical signals that…”
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Picomolar Nitric Oxide Signals from Central Neurons Recorded Using Ultrasensitive Detector Cells by Wood, Katherine C., Batchelor, Andrew M., Bartus, Katalin, Harris, Kathryn L., Garthwaite, Giti, Vernon, Jeffrey, Garthwaite, John

“…Nitric oxide (NO) is a widespread signaling molecule with potentially multifarious actions of relevance to health and disease. A fundamental determinant of how…”
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Metabotropic glutamate receptor subtypes modulating neurotransmission at parallel fibre–Purkinje cell synapses in rat cerebellum by Neale, Stuart A., Garthwaite, John, M. Batchelor, Andrew

“…The actions of reportedly group-selective metabotropic glutamate (mGlu) receptor agonists and antagonists on neurotransmission at parallel fibre–Purkinje cell…”
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The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors by Fukunaga, Izumi, Yeo, Christopher H., Batchelor, Andrew M.

“…CPCCOEt (7-(hydroxyimino)cyclopropa[ b]chromen-1a-carboxylate ethyl ester) is frequently used to test for the involvement of mGlu1 receptors. Using whole-cell…”
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mGlu1 receptors mediate a post-tetanic depression at parallel fibre-Purkinje cell synapses in rat cerebellum by Neale, Stuart A., Garthwaite, John, Batchelor, Andrew M.

“…Metabotropic glutamate (mGlu) receptors are located pre‐ and postsynaptically at central synapses. Activation of the receptors by exogenous agonists usually…”
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The synaptic potential mediated by metabotropic glutamate receptors is not associated with a substantial elevation of cytosolic free calcium concentration in Purkinje cells by Batchelor, A M, Vranesic, I, Del Principe, F, Garthwaite, J, Knöpfel, T

“…Brief tetanic stimulation of parallel fibres can evoke a slow excitatory postsynaptic potential (EPSP) in cerebellar Purkinje cells that is mediated by…”
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Synaptic integration by mGluRs in cerebellar purkinje cells by Batchelor, Andrew M, Garthwaite, John

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A biplanar slice preparation for studying cerebellar synaptic transmission by Garthwaite, John, Batchelor, Andrew M.

“…Unlike certain other brain areas, notably the hippocampal formation, synaptic transmission in the cerebellum, a 3-dimensional anatomical structure, is not…”
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Selective blockade of N-methyl-D-aspartate receptor function by the nitric oxide donor, nitroprusside by East, S J, Batchelor, A M, Garthwaite, J

“…The N-methyl-D-aspartate (NMDA) receptor-mediated component of the synaptic response of cerebellar granule cells to mossy fibre stimulation was selectively…”
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