Search Results - "M. Antunes, Alexandra M."

Integration of cellular and molecular endpoints to assess the toxicity of polycyclic aromatic hydrocarbons in HepG2 cell line by Morgado, Patrícia I., Jose, Sílvia, Wanke, Riccardo, M. Antunes, Alexandra M., Cardoso, Ana Sofia, Jordao, Luisa

“…Polycyclic aromatic hydrocarbons (PAHs) are persistent pollutants present in the environment with known mutagenic and carcinogenic properties. In the present…”
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Bioactivity of Isostructural Hydrogen Bonding Frameworks Built from Pipemidic Acid Metal Complexes by Alves, Paula C, Rijo, Patrícia, Bravo, Catarina, Antunes, Alexandra M M, André, Vânia

“…We report herein three novel complexes whose design was based on the approach that consists of combining commercially available antibiotics with metals to…”
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Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study by de Conti, Aline, Tryndyak, Volodymyr, VonTungeln, Linda S, Churchwell, Mona I, Beland, Frederick A, Antunes, Alexandra M. M, Pogribny, Igor P

“…Acrylamide has been classified as a “Group 2A carcinogen” (probably carcinogenic to humans) by the International Agency for Research on Cancer. The…”
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16α-Hydroxyestrone: Mass Spectrometry-Based Methodologies for the Identification of Covalent Adducts Formed with Blood Proteins by Charneira, Catarina, Nunes, João, Antunes, Alexandra M. M

“…Elevated levels of the estrone metabolite, 16α-hydroxyestrone (16αOHE1), have been linked with multiple diseases. As an electrophilic reactive metabolite,…”
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Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy by Martins, Inês L, Charneira, Catarina, Gandin, Valentina, Ferreira da Silva, João L, Justino, Gonçalo C, Telo, João P, Vieira, Abel J. S. C, Marzano, Cristina, Antunes, Alexandra M. M

“…Selenium-containing chrysin (SeChry) and 3,7,3′,4′-tetramethylquercetin (SePQue) derivatives were synthesized by a microwave-based methodology. In addition to…”
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A simple method to measure sulfonation in man using paracetamol as probe drug by Marto, Natália, Morello, Judit, Antunes, Alexandra M. M., Azeredo, Sofia, Monteiro, Emília C., Pereira, Sofia A.

“…Sulfotransferase enzymes (SULT) catalyse sulfoconjugation of drugs, as well as endogenous mediators, gut microbiota metabolites and environmental xenobiotics…”
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New ruthenium-cyclopentadienyl complexes affect colorectal cancer hallmarks showing high therapeutic potential by Brás, Ana Rita, Fernandes, Pedro, Moreira, Tiago, Morales-Sanfrutos, Julia, Sabidó, Eduard, Antunes, Alexandra M. M., Valente, Andreia, Preto, Ana

“…Colorectal cancer (CRC) is among the most deadly cancers worldwide. Current therapeutic strategies have low success rates and several side effects. This…”
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Molecular Motions in Amorphous Ibuprofen As Studied by Broadband Dielectric Spectroscopy by Brás, Ana R, Noronha, João P, Antunes, Alexandra M. M, Cardoso, Maria M, Schönhals, Andreas, Affouard, Frédéric, Dionísio, Madalena, Correia, Natália T

“…The molecular mobility of amorphous ibuprofen has been investigated by broadband dielectric relaxation spectroscopy (DRS) covering a temperature range of more…”
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Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study by Pinheiro, Pedro F., Pereira, Sofia A., Harjivan, Shrika G., Martins, Inês L., Marinho, Aline T., Cipriano, Madalena, Jacob, Cristina C., Oliveira, Nuno G., Castro, Matilde F., Marques, M. Matilde, Antunes, Alexandra M. M., Miranda, Joana P.

“…The development of metabolically competent in vitro models is of utmost importance for predicting adverse drug reactions, thereby preventing attrition-related…”
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Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators by Barcherini, Valentina, Loureiro, Joana B, Sena, Ana, Madeira, Catarina, Leandro, Paula, Saraiva, Lucília, Antunes, Alexandra M M, Santos, Maria M M

“…For the first time, the pharmacokinetic (PK) profile of tryptophanol-derived isoindolinones, previously reported as p53 activators, was investigated. From the…”
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First Chemical Profile Analysis of Acacia Pods by Pedro, Soraia I, Fernandes, Tiago A, Luís, Ângelo, Antunes, Alexandra M M, Gonçalves, José C, Gominho, Jorge, Gallardo, Eugenia, Anjos, Ofélia

“…This study intended to evaluate the potential industrial applications of various species ( , , , , , , and ) by examining their chemical composition,…”
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Mg- and Mn-MOFs Boost the Antibiotic Activity of Nalidixic Acid by André, Vânia, da Silva, André Ramires Ferreira, Fernandes, Auguste, Frade, Raquel, Garcia, Catarina, Rijo, Patrícia, Antunes, Alexandra M. M, Rocha, João, Duarte, M. Teresa

“…The development of metal–organic frameworks (MOFs) enclosing active pharmaceutical ingredients is of considerable interest, as their use in controlled drug…”
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Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine by Correia, Maria João, Pimpão, António B, Fernandes, Dalila G F, Morello, Judit, Sequeira, Catarina O, Calado, Joaquim, Antunes, Alexandra M M, Almeida, Manuel S, Branco, Patrícia, Monteiro, Emília C, Vicente, João B, Serpa, Jacinta, Pereira, Sofia A

“…In this review encouraged by original data, we first provided in vivo evidence that the kidney, comparative to the liver or brain, is an organ particularly…”
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Metabolic stability and metabolite profiling of emerging synthetic cathinones by Lopes, Rita P, Ferro, Raquel A, Milhazes, Margarida, Figueira, Margarida, Caldeira, Maria João, Antunes, Alexandra M M, Gaspar, Helena

“…Synthetic cathinones constitute the second largest groups of new psychoactive substances (NPS), which are especially popular among adolescents and young…”
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Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment by Selenium-Chrysin Polyurea Dendrimer Nanoformulation by Santos, Inês, Ramos, Cristiano, Mendes, Cindy, Sequeira, Catarina O, Tomé, Catarina S, Fernandes, Dalila G H, Mota, Pedro, Pires, Rita F, Urso, Donato, Hipólito, Ana, Antunes, Alexandra M M, Vicente, João B, Pereira, Sofia A, Bonifácio, Vasco D B, Nunes, Sofia C, Serpa, Jacinta

“…Ovarian cancer is the main cause of death from gynecological cancer, with its poor prognosis mainly related to late diagnosis and chemoresistance (acquired or…”
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Reactive Aldehyde Metabolites from the Anti-HIV Drug Abacavir: Amino Acid Adducts as Possible Factors in Abacavir Toxicity by Charneira, Catarina, Godinho, Ana L. A, Oliveira, M. Conceição, Pereira, Sofia A, Monteiro, Emília C, Marques, M. Matilde, Antunes, Alexandra M. M

“…Abacavir is a nucleoside reverse transcriptase inhibitor marketed since 1999 for the treatment of infection with the human immunodeficiency virus type 1 (HIV)…”
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Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine by Harjivan, Shrika G, Charneira, Catarina, Martins, Inês L, Pereira, Sofia A, Espadas, Guadalupe, Sabidó, Eduard, Beland, Frederick A, Marques, M Matilde, Antunes, Alexandra M M

“…Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor widely used in combined antiretroviral therapy and to prevent mother-to-child transmission…”
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Metabolic Profile of Four Selected Cathinones in Microsome Incubations: Identification of Phase I and II Metabolites by Liquid Chromatography High Resolution Mass Spectrometry by Lopes, Beatriz T, Caldeira, Maria João, Gaspar, Helena, Antunes, Alexandra M M

“…Consumption of synthetic cathinones, the second largest class of new psychoactive substances (NPS) reported worldwide, represents a serious public health risk…”
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Protein Adducts As Prospective Biomarkers of Nevirapine Toxicity by Antunes, Alexandra M. M, Godinho, Ana L. A, Martins, Inês L, Oliveira, M. Conceição, Gomes, Ricardo A, Coelho, Ana V, Beland, Frederick A, Marques, M. Matilde

“…Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor used against human immunodeficiency virus type-1 (HIV-1), mostly to prevent…”
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Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model by Cipriano, Madalena, Pinheiro, Pedro F, Sequeira, Catarina O, Rodrigues, Joana S, Oliveira, Nuno G, Antunes, Alexandra M M, Castro, Matilde, Marques, M Matilde, Pereira, Sofia A, Miranda, Joana P

“…The need for competent in vitro liver models for toxicological assessment persists. The differentiation of stem cells into hepatocyte-like cells (HLC) has been…”
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