Search Results - "M VALDES, Ana"

Role of the gut microbiota in nutrition and health by Valdes, Ana M, Walter, Jens, Segal, Eran, Spector, Tim D

“…Ana M Valdes and colleagues discuss strategies for modulating the gut microbiota through diet and probiotics…”
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The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health by Nogal, Ana, Valdes, Ana M., Menni, Cristina

“…The gut microbiota plays an important role in cardio-metabolic diseases with diet being among the strongest modulators of gut microbiota composition and…”
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Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study by Menni, Cristina, Klaser, Kerstin, May, Anna, Polidori, Lorenzo, Capdevila, Joan, Louca, Panayiotis, Sudre, Carole H, Nguyen, Long H, Drew, David A, Merino, Jordi, Hu, Christina, Selvachandran, Somesh, Antonelli, Michela, Murray, Benjamin, Canas, Liane S, Molteni, Erika, Graham, Mark S, Modat, Marc, Joshi, Amit D, Mangino, Massimo, Hammers, Alexander, Goodman, Anna L, Chan, Andrew T, Wolf, Jonathan, Steves, Claire J, Valdes, Ana M, Ourselin, Sebastien, Spector, Tim D

“…The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We…”
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The fecal metabolome as a functional readout of the gut microbiome by Zierer, Jonas, Jackson, Matthew A., Kastenmüller, Gabi, Mangino, Massimo, Long, Tao, Telenti, Amalio, Mohney, Robert P., Small, Kerrin S., Bell, Jordana T., Steves, Claire J., Valdes, Ana M., Spector, Tim D., Menni, Cristina

“…The human gut microbiome plays a key role in human health 1 , but 16S characterization lacks quantitative functional annotation 2 . The fecal metabolome…”
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Real-time tracking of self-reported symptoms to predict potential COVID-19 by Menni, Cristina, Valdes, Ana M., Freidin, Maxim B., Sudre, Carole H., Nguyen, Long H., Drew, David A., Ganesh, Sajaysurya, Varsavsky, Thomas, Cardoso, M. Jorge, El-Sayed Moustafa, Julia S., Visconti, Alessia, Hysi, Pirro, Bowyer, Ruth C. E., Mangino, Massimo, Falchi, Mario, Wolf, Jonathan, Ourselin, Sebastien, Chan, Andrew T., Steves, Claire J., Spector, Tim D.

“…A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2…”
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Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven nonalcoholic steatohepatitis by Astbury, Stuart, Atallah, Edmond, Vijay, Amrita, Aithal, Guruprasad P, Grove, Jane I, Valdes, Ana M

“…There is increasing evidence for the role of gut microbial composition in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Nonalcoholic…”
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Genetics of the HLA Region in the Prediction of Type 1 Diabetes by Noble, Janelle A., Valdes, Ana M.

“…Type 1 diabetes (T1D) is one of the most widely studied complex genetic disorders, and the genes in HLA are reported to account for approximately 40–50% of the…”
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Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease by Kaye, David M., Shihata, Waled A., Jama, Hamdi A., Tsyganov, Kirill, Ziemann, Mark, Kiriazis, Helen, Horlock, Duncan, Vijay, Amrita, Giam, Beverly, Vinh, Antony, Johnson, Chad, Fiedler, April, Donner, Daniel, Snelson, Matthew, Coughlan, Melinda T., Phillips, Sarah, Du, Xiao-Jun, El-Osta, Assam, Drummond, Grant, Lambert, Gavin W., Spector, Tim D., Valdes, Ana M., Mackay, Charles R., Marques, Francine Z.

“…BACKGROUND:High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle…”
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Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat by Nogal, Ana, Louca, Panayiotis, Zhang, Xinyuan, Wells, Philippa M, Steves, Claire J, Spector, Tim D, Falchi, Mario, Valdes, Ana M, Menni, Cristina

“…Acetate is a short-chain fatty acid (SCFA) produced by gut bacteria, which has been implicated in cardio-metabolic health. Here we examine the relationships of…”
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Blue poo: impact of gut transit time on the gut microbiome using a novel marker by Asnicar, Francesco, Leeming, Emily R, Dimidi, Eirini, Mazidi, Mohsen, Franks, Paul W, Al Khatib, Haya, Valdes, Ana M, Davies, Richard, Bakker, Elco, Francis, Lucy, Chan, Andrew, Gibson, Rachel, Hadjigeorgiou, George, Wolf, Jonathan, Spector, Timothy D, Segata, Nicola, Berry, Sarah E

“…Gut transit time is a key modulator of host-microbiome interactions, yet this is often overlooked, partly because reliable methods are typically expensive or…”
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The prebiotic effects of omega-3 fatty acid supplementation: A six-week randomised intervention trial by Vijay, Amrita, Astbury, Stuart, Le Roy, Caroline, Spector, Tim D, Valdes, Ana M

“…Prebiotics are compounds in food that benefit health via affecting the gut microbiome. Omega-3 fatty acids have been associated with differences in gut…”
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Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families by Kuo, Chang-Fu, Grainge, Matthew J, Valdes, Ana M, See, Lai-Chu, Luo, Shue-Fen, Yu, Kuang-Hui, Zhang, Weiya, Doherty, Michael

“…Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual…”
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Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO) by Biver, Emmanuel, Berenbaum, Francis, Valdes, Ana M, Araujo de Carvalho, Islene, Bindels, Laure B, Brandi, Maria Luisa, Calder, Philip C, Castronovo, Vincenzo, Cavalier, Etienne, Cherubini, Antonio, Cooper, Cyrus, Dennison, Elaine, Franceschi, Claudio, Fuggle, Nicholas, Laslop, Andrea, Miossec, Pierre, Thomas, Thierry, Tuzun, Sansin, Veronese, Nicola, Vlaskovska, Mila, Reginster, Jean-Yves, Rizzoli, René

“…The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical…”
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The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients by Kouraki, Afroditi, Bast, Tobias, Ferguson, Eamonn, Valdes, Ana M.

“…Previous research has established links between chronic pain and impaired cognitive ability, as well as between chronic pain and anxiety, in osteoarthritis…”
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Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains by Rakyan, Vardhman K, Down, Thomas A, Maslau, Siarhei, Andrew, Toby, Yang, Tsun-Po, Beyan, Huriya, Whittaker, Pamela, McCann, Owen T, Finer, Sarah, Valdes, Ana M, Leslie, R David, Deloukas, Panogiotis, Spector, Timothy D

“…There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of…”
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A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population by Sekula, Peggy, Goek, Oemer-Necmi, Quaye, Lydia, Barrios, Clara, Levey, Andrew S, Römisch-Margl, Werner, Menni, Cristina, Yet, Idil, Gieger, Christian, Inker, Lesley A, Adamski, Jerzy, Gronwald, Wolfram, Illig, Thomas, Dettmer, Katja, Krumsiek, Jan, Oefner, Peter J, Valdes, Ana M, Meisinger, Christa, Coresh, Josef, Spector, Tim D, Mohney, Robert P, Suhre, Karsten, Kastenmüller, Gabi, Köttgen, Anna

“…Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and…”
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Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health by Kirk, Daniel, Costeira, Ricardo, Visconti, Alessia, Khan Mirzaei, Mohammadali, Deng, Li, Valdes, Ana M., Menni, Cristina

“…Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the…”
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Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis - A Cross-Sectional Study by Mehta, Ojasvi, Vijay, Amrita, Gohir, Sameer A, Kelly, Tony, Zhang, Weiya, Doherty, Michael, Walsh, David A, Aithal, Guruprasad, Valdes, Ana M

“…Osteoarthritis (OA) is the most common arthritis affecting synovial joints such as knees and hips of millions of people globally. Usage-related joint pain and…”
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Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes by Menni, Cristina, Zhu, Jialing, Le Roy, Caroline I, Mompeo, Olatz, Young, Kristin, Rebholz, Casey M., Selvin, Elizabeth, North, Kari E., Mohney, Robert P, Bell, Jordana T, Boerwinkle, Eric, Spector, Tim D, Mangino, Massimo, Yu, Bing, Valdes, Ana M

“…Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity, although the cause is unclear. Metabolites generated by gut microbes also appear to…”
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Triggers of acute attacks of gout, does age of gout onset matter? A primary care based cross-sectional study by Abhishek, Abhishek, Valdes, Ana M, Jenkins, Wendy, Zhang, Weiya, Doherty, Michael

“…To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and…”
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