Search Results - "M Shireman, Jack"

Transcriptomic and proteomic spatial profiling of pediatric and adult diffuse midline glioma H3 K27-Altered by Damodharan, Sudarshawn, Shireman, Jack M., Xie, Elliot, Distler, Emily, Kendziorski, Christina, Dey, Mahua

“…Diffuse midline glioma, H3 K27 -altered (DMG) are highly aggressive malignancies of the central nervous system (CNS) that primarily affect the pediatric…”
Get full text

Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma by Hasan, Tanwir, Caragher, Seamus P., Shireman, Jack M., Park, Cheol H., Atashi, Fatemeh, Baisiwala, Shivani, Lee, Gina, Guo, Donna, Wang, Jennifer Y., Dey, Mahua, Wu, Meijing, Lesniak, Maciej S., Horbinski, Craig M., James, C. David, Ahmed, Atique U.

“…Emerging evidence reveals enrichment of glioma-initiating cells (GICs) following therapeutic intervention. One factor known to contribute to this enrichment is…”
Get full text

Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough? by Shireman, Jack M, Cheng, Lingxin, Goel, Amiti, Garcia, Diogo Moniz, Partha, Sanil, Quiñones-Hinojosa, Alfredo, Kendziorski, Christina, Dey, Mahua

“…Spatial transcriptomics, the technology of visualizing cellular gene expression landscape in a cells native tissue location, has emerged as a powerful tool…”
Get full text

A Comparison Between Chemo-Radiotherapy Combined With Immunotherapy and Chemo-Radiotherapy Alone for the Treatment of Newly Diagnosed Glioblastoma: A Systematic Review and Meta-Analysis by Lara-Velazquez, Montserrat, Shireman, Jack M, Lehrer, Eric J, Bowman, Kelsey M, Ruiz-Garcia, Henry, Paukner, Mitchell J, Chappell, Richard J, Dey, Mahua

“…Immunotherapy for GBM is an emerging field which is increasingly being investigated in combination with standard of care treatment options with variable…”
Get full text

LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population during Temozolomide Therapy in Glioblastoma by Baisiwala, Shivani, Hall, 3rd, Robert R, Saathoff, Miranda R, M Shireman, Jack, Park, Cheol, Budhiraja, Shreya, Goel, Chirag, Warnke, Louisa, Hardiman, Clare, Wang, Jennifer Y, McCortney, Katy, Horbinski, Craig M, Ahmed, Atique U

“…Glioblastoma (GBM) is the most common primary brain malignancy in adults, with a 100% recurrence rate and 21-month median survival. Our lab and others have…”
Get full text

Chemotherapeutic Stress Induces Transdifferentiation of Glioblastoma Cells to Endothelial Cells and Promotes Vascular Mimicry by Christensen, Anne C., Ahmed, Atique U., Saathoff, Miranda R., Hasan, Tanwir, Lee, Gina, Ahsan, Riasat, Shireman, Jack M., Caragher, Seamus P., Auffinger, Brenda, Baisiwala, Shivani, Park, Cheol

“…Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor affecting adults, with a median survival of approximately 21 months. One key…”
Get full text

Genomic analysis of human brain metastases treated with stereotactic radiosurgery reveals unique signature based on treatment failure by Shireman, Jack M., White, Quinn, Ni, Zijian, Mohanty, Chitrasen, Cai, Yujia, Zhao, Lei, Agrawal, Namita, Gonugunta, Nikita, Wang, Xiaohu, Mccarthy, Liam, Kasulabada, Varshitha, Pattnaik, Akshita, Ahmed, Atique U., Miller, James, Kulwin, Charles, Cohen-Gadol, Aaron, Payner, Troy, Lin, Chih-Ta, Savage, Jesse J., Lane, Brandon, Shiue, Kevin, Kamer, Aaron, Shah, Mitesh, Iyer, Gopal, Watson, Gordon, Kendziorski, Christina, Dey, Mahua

“…Stereotactic radiosurgery (SRS) has been shown to be efficacious for the treatment of limited brain metastasis (BM); however, the effects of SRS on human brain…”
Get full text

Surgical Neuro-Oncology: Management of Glioma by Mitchell, Dana, Shireman, Jack M, Dey, Mahua

“…Gliomas are the most common intrinsic brain tumor in adults. Although maximal tumor resection improves survival, this must be balanced with preservation of…”
Get full text

GM‐CSF and IL‐7 fusion cytokine engineered tumor vaccine generates long‐term Th‐17 memory cells and increases overall survival in aged syngeneic mouse models of glioblastoma by Shireman, Jack M., Gonugunta, Nikita, Zhao, Lei, Pattnaik, Akshita, Distler, Emily, Her, Skyler, Wang, Xiaohu, Das, Rahul, Galipeau, Jaques, Dey, Mahua

“…Age‐related immune dysfunctions, such as decreased T‐cell output, are closely related to pathologies like cancers and lack of vaccine efficacy among the…”
Get full text

Activation of Dopamine Receptor 2 Prompts Transcriptomic and Metabolic Plasticity in Glioblastoma by Caragher, Seamus P, Shireman, Jack M, Huang, Mei, Miska, Jason, Atashi, Fatemeh, Baisiwala, Shivani, Hong Park, Cheol, Saathoff, Miranda R, Warnke, Louisa, Xiao, Ting, Lesniak, Maciej S, James, C David, Meltzer, Herbert, Tryba, Andrew K, Ahmed, Atique U

“…Glioblastoma (GBM) is one of the most aggressive and lethal tumor types. Evidence continues to accrue indicating that the complex relationship between GBM and…”
Get full text

Separate and not equal: sex differences in JAM-A tumor suppression in glioblastoma by Shireman, Jack M, Ahmed, Atique U

Get full text

De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma by Shireman, Jack M, Atashi, Fatemeh, Lee, Gina, Ali, Eunus S, Saathoff, Miranda R, Park, Cheol H, Savchuk, Sol, Baisiwala, Shivani, Miska, Jason, Lesniak, Maciej S, James, C David, Stupp, Roger, Kumthekar, Priya, Horbinski, Craig M, Ben-Sahra, Issam, Ahmed, Atique U

“…Glioblastoma is a primary brain cancer with a near 100% recurrence rate. Upon recurrence, the tumour is resistant to all conventional therapies, and because of…”
Get full text

Sexual dimorphism of the immune system predicts clinical outcomes in glioblastoma immunotherapy: A systematic review and meta-analysis by Shireman, Jack M, Ammanuel, Simon, Eickhoff, Jens C, Dey, Mahua

“…Abstract Background Biological differences based on sex have been documented throughout the scientific literature. Glioblastoma (GBM), the most common primary…”
Get full text

Alcohol’s Effects During Uncertain and Uncontrollable Stressors in the Laboratory by Bradford, Daniel E., Shireman, Jack M., Sant’Ana, Sarah J., Fronk, Gaylen E., Schneck, Susan E., Curtin, John J.

“…Alcohol’s effects on reactivity to stressors depend on the nature of the stressor and the reactivity being assessed. Research that identifies characteristics…”
Get full text

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production by Perrault, Ella N, Shireman, Jack M, Ali, Eunus S, Lin, Peiyu, Preddy, Isabelle, Park, Cheol, Budhiraja, Shreya, Baisiwala, Shivani, Dixit, Karan, James, C David, Heiland, Dieter H, Ben-Sahra, Issam, Pott, Sebastian, Basu, Anindita, Miska, Jason, Ahmed, Atique U

“…During therapy, adaptations driven by cellular plasticity are partly responsible for driving the inevitable recurrence of glioblastoma (GBM). To investigate…”
Get full text

Preoperative stereotactic radiosurgery for patients with 1-4 brain metastases: A single-arm phase 2 trial outcome analysis (NCT03398694) by Agrawal, Namita, Shireman, Jack M, Shiue, Kevin, Kamer, Aaron, Boyd, LaKeisha, Zang, Yong, Mukherjee, Neel, Miller, James, Kulwin, Charles, Cohen-Gadol, Aaron, Payner, Troy, Lin, Chih-Ta, Savage, Jesse J, Lane, Brandon, Bohnstedt, Bradley, Lautenschlaeger, Tim, Saito, Naoyuki, Shah, Mitesh, Watson, Gordon, Dey, Mahua

“…Stereotactic radiosurgery (SRS) following surgical resection is the standard of care for patients with symptomatic oligo brain metastasis (BM), however, it is…”
Get full text

Aging- and Tumor-Mediated Increase in CD8 + CD28 - T Cells Might Impose a Strong Barrier to Success of Immunotherapy in Glioblastoma by Huff, Wei X, Bam, Marpe, Shireman, Jack M, Kwon, Jae Hyun, Song, Leo, Newman, Sharlé, Cohen-Gadol, Aaron A, Shapiro, Scott, Jones, Tamara, Fulton, Kelsey, Liu, Sheng, Tanaka, Hiromi, Liu, Yunlong, Wan, Jun, Dey, Mahua

“…Clinical use of various forms of immunotherapeutic drugs in glioblastoma (GBM), has highlighted severe T cell dysfunction such as exhaustion in GBM patients…”
Get full text

Surgical Neuro-Oncology by Mitchell, Dana, Shireman, Jack M., Dey, Mahua

“…Gliomas are the most common intrinsic brain tumor in adults. Although maximal tumor resection improves survival, this must be balanced with preservation of…”
Get full text

Abstract 197: Identifying a novel network of driver genes in glioblastoma by Baisiwala, Shivani, Park, Cheol, Awah, Chidibere, Shireman, Jack M., Saathoff, Miranda R., Sonabend, Adam, Ahmed, Atique U.

“…The purpose of this study is to identify novel genes that drive proliferation in glioblastoma (GBM) and likely contribute to gliomagenesis, therefore…”
Get full text

Abstract B034: Targeting cellular plasticity-driven metabolic adaptation to overcome chemoresistance in GBM by Ahmed, Atique U., Shireman, Jack M., Atash, Fatemeh, Lee, Gina, Ali, Eunus S., Saathoff, Miranda R., Park, Cheol H., Savchuk, Sol, Baisiwala, Shivani, Miska, Jason, Lesniak, Maciej S., James, C. David, Stupp, Roger, Kumthekar, Priya, Horbinski, Craig M., Ben-Sahra, Issam

“…This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Proffered Abstracts section (PR011) of the…”
Get full text