Daclatasvir plus simeprevir with or without ribavirin for the treatment of chronic hepatitis C virus genotype 1 infection

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Bibliographic Details
Published in:	Journal of hepatology Vol. 64; no. 2; pp. 292 - 300
Main Authors:	Zeuzem, Stefan, Hézode, Christophe, Bronowicki, Jean-Pierre, Loustaud-Ratti, Veronique, Gea, Francisco, Buti, Maria, Olveira, Antonio, Banyai, Tivadar, Al-Assi, M. Tarek, Petersen, Joerg, Thabut, Dominique, Gadano, Adrian, Pruitt, Ronald, Makara, Mihály, Bourlière, Marc, Pol, Stanislas, Beumont-Mauviel, Maria, Ouwerkerk-Mahadevan, Sivi, Picchio, Gaston, Bifano, Marc, M Phee, Fiona, Boparai, Navdeep, Cheung, Kin, Hughes, Eric A, Noviello, Stephanie
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-02-2016 Elsevier
Subjects:	Adult Aged All-oral therapy Antiviral Agents Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Daclatasvir Direct-acting antiviral DNA, Viral DNA, Viral - analysis Dose-Response Relationship, Drug Drug Administration Schedule Drug Monitoring Female Gastroenterology and Hepatology Genotype Genotype 1 Hepacivirus Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C virus Hepatitis C, Chronic Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Humans Imidazoles Imidazoles - administration & dosage Imidazoles - adverse effects Life Sciences Male Middle Aged NS3 protease inhibitor NS5A inhibitor Ribavirin Ribavirin - administration & dosage Ribavirin - adverse effects Simeprevir Simeprevir - administration & dosage Simeprevir - adverse effects Treatment Outcome asuneprevir LLOQ RAV Direct-acting antiviral Genotype 1 SVR12 SVR peginterferon simeprevir ULN hepatitis C virus All-oral therapy sustained virologic response PegIFN resistance-associated variant lower limit of quantitation ribavirin ASV AE RBV NS5A inhibitor adverse event NS3 protease inhibitor sustained virologic response at posttreatment week 12 daclatasvir upper limit of normal DCV HCV SMV Simeprevir Daclatasvir Hepatitis C virus
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Summary:	Graphical abstract
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	0168-8278 1600-0641
DOI:	10.1016/j.jhep.2015.09.024