Search Results - "M K Hellerstein"

Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study by Beysen, C., Murphy, E. J., Deines, K., Chan, M., Tsang, E., Glass, A., Turner, S. M., Protasio, J., Riiff, T., Hellerstein, M. K.

“…Aims/hypothesis The primary aim of this completed multicentre randomised, parallel, double-blind placebo-controlled study was to elucidate the mechanisms of…”
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Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice by Fanara, P, Husted, K.H, Selle, K, Wong, P.-Y.A, Banerjee, J, Brandt, R, Hellerstein, M.K

“…Abstract Synaptic plasticity plays a crucial role in learning, memory, and cognitive disorders. Cytoskeletal reorganization underlies neuronal synaptic…”
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De novo lipogenesis in humans: metabolic and regulatory aspects by Hellerstein, M K

“…The enzymatic pathway for converting dietary carbohydrate (CHO) into fat, or de novo lipogenesis (DNL), is present in humans, whereas the capacity to convert…”
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Carbohydrate-induced hypertriacylglycerolemia : historical perspective and review of biological mechanisms by PARKS, E. J, HELLERSTEIN, M. K

“…Current trends in health promotion emphasize the importance of reducing dietary fat intake. However, as dietary fat is reduced, the dietary carbohydrate…”
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Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice by Varady, K.A., Roohk, D.J., Loe, Y.C., McEvoy-Hein, B.K., Hellerstein, M.K.

“…Calorie restriction (CR) affects adipocyte function and reduces body weight. However, the effects of alternate-day fasting (ADF) on adipose biology remain…”
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Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice by Turner, S M, Roy, S, Sul, H S, Neese, R A, Murphy, E J, Samandi, W, Roohk, D J, Hellerstein, M K

“…Recent evidence has been presented that expression of lipogenic genes is downregulated in adipose tissue of ob/ob mice as well as in human obesity, suggesting…”
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Modified alternate‐day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice by Varady, K. A., Roohk, D. J., McEvoy‐Hein, B. K., Gaylinn, B. D., Thorner, M. O., Hellerstein, M. K.

“…Calorie restriction (CR) and alternate‐ day fasting (ADF) reduce cancer risk and reduce cell proliferation rates. Whether modified ADF regimens (i.e., allowing…”
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A stable isotope-mass spectrometric method for measuring human spermatogenesis kinetics in vivo by Misell, L M, Holochwost, D, Boban, D, Santi, N, Shefi, S, Hellerstein, M K, Turek, P J

“…Currently it is thought to take 60 to 70 days to produce and ejaculate human sperm. This estimate is derived mainly from a single older, descriptive, kinetic…”
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Regulation of hepatic de novo lipogenesis in humans by Hellerstein, M.K. (University of California-Berkeley, Berkeley, CA.), Schwarz, J.M, Neese, R.A

“…The enzymatic pathway for synthesis of fatty acids from acetyl-coenzyme A, or de novo lipogenesis (DNL), is present in human liver and, to a lesser extent, in…”
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Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers by Hellerstein, M K, Neese, R A

“…Mass isotopomer distribution analysis (MIDA) is a technique for measuring biosynthesis and turnover of polymers in vivo. A stable isotopically enriched…”
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T Cell Turnover in HIV-1 Disease by Hellerstein, M.K, McCune, J.M

“…A powerful "high turnover" model of human immunodeficiency virus type 1 (HIV-1) immunopathogenesis has been developed over the past several years. This model…”
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Dynamic Proteomics: In Vivo Proteome-Wide Measurement of Protein Kinetics Using Metabolic Labeling by Holmes, W E, Angel, T E, Li, K W, Hellerstein, M K

“…Control of biosynthetic and catabolic rates of polymers, including proteins, stands at the center of phenotype, physiologic adaptation, and disease…”
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Effect of pinitol treatment on insulin action in subjects with insulin resistance by A Davis, M Christiansen, J F Horowitz, S Klein, M K Hellerstein, R E Ostlund, Jr

“…Effect of pinitol treatment on insulin action in subjects with insulin resistance. A Davis , M Christiansen , J F Horowitz , S Klein , M K Hellerstein and R E…”
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De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption by SILER, S. Q, NEESE, R. A, HELLERSTEIN, M. K

“…Acute alcohol intake is associated with changes in plasma lipid concentrations and whole-body lipid balances in humans. The quantitative roles of hepatic de…”
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Resistance Exercise and Supraphysiologic Androgen Therapy in Eugonadal Men With HIV-Related Weight Loss: A Randomized Controlled Trial by Strawford, Alison, Barbieri, Theresa, Van Loan, Marta, Parks, Elizabeth, Catlin, Don, Barton, Norman, Neese, Richard, Christiansen, Mark, King, Janet, Hellerstein, Marc K

“…CONTEXT Repletion of lean body mass (LBM) that patients lose in human immunodeficiency virus (HIV) infection has proved difficult. In healthy, HIV-seronegative…”
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No common energy currency: de novo lipogenesis as the road less traveled by Hellerstein, M K

“…Hellerstein discusses the role of de novo lipogenesis in energy production in animals. While scientists previously thought that animals used de novo…”
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Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study by Hellerstein, M K, Neese, R A, Linfoot, P, Christiansen, M, Turner, S, Letscher, A

“…Fluxes through intrahepatic glucose-producing metabolic pathways were measured in normal humans during overnight or prolonged (60 h) fasting. The glucuronate…”
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Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection by Schwarz, J M, Neese, R A, Turner, S, Dare, D, Hellerstein, M K

“…Short-term alterations in dietary carbohydrate (CHO) energy are known to alter whole-body fuel selection in humans, but the metabolic mechanisms remain…”
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Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100 by Véniant, M M, Sullivan, M A, Kim, S K, Ambroziak, P, Chu, A, Wilson, M D, Hellerstein, M K, Rudel, L L, Walzem, R L, Young, S G

“…Apo-E-deficient apo-B100-only mice (APOE:(-/-)APOB:(100/100)) and LDL receptor-deficient apo-B100-only mice (LDLR:(-/-)APOB:(100/100)) have similar total…”
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Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia by Murphy, E J, Neuberg, D S, Rassenti, L Z, Hayes, G, Redd, R, Emson, C, Li, K, Brown, J R, Wierda, W G, Turner, S, Greaves, A W, Zent, C S, Byrd, J C, McConnel, C, Barrientos, J, Kay, N, Hellerstein, M K, Chiorazzi, N, Kipps, T J, Rai, K R

“…The clinical course of patients with recently diagnosed early stage chronic lymphocytic leukemia (CLL) is highly variable. We examined the relationship between…”
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