Search Results - "M J Karnovsky"

Perivascular and Intravenous Administration of Basic Fibroblast Growth Factor: Vascular and Solid Organ Deposition by Edelman, Elazer R., Nugent, Matthew A., Karnovsky, Morris J.

“…The in vivo mitogenicity of basic fibroblast growth factor (bFGF) for arterial smooth muscle cells relies on the removal of endothelium, raising the question…”
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Intracellular singlet oxygen generation by phagocytosing neutrophils in response to particles coated with a chemical trap by STEINBECK, M. J, KHAN, A. U, KARNOVSKY, M. J

“…To determine if singlet oxygen (O2(1 delta g)) is produced by neutrophils (PMNs) during the process of phagocytosis, glass beads were coated with a specific…”
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Monocyte Recruitment and Neointimal Hyperplasia in Rabbits: Coupled Inhibitory Effects of Heparin by Rogers, Campbell, Welt, Frederick G.P, Karnovsky, Morris J, Edelman, Elazer R

“…Among the many effects of heparin independent of its effects on coagulation are inhibition of vascular smooth muscle cell proliferation and regulation of…”
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NADPH-Oxidase Expression and in situ Production of Superoxide by Osteoclasts Actively Resorbing Bone by Steinbeck, Marla J., Appel, William H., Verhoeven, Arthur J., Karnovsky, Morris J.

“…Recent reports have suggested that production of superoxide or other reactive oxygen species by activated osteoclasts may play a role in the complex process of…”
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Inhibition of experimental neointimal hyperplasia and thrombosis depends on the type of vascular injury and the site of drug administration by ROGERS, C, KARNOVSKY, M. J, EDELMAN, E. R

“…Heparin inhibits vascular smooth muscle cell proliferation in tissue culture and limits neointimal hyperplasia after experimental arterial injury but has been…”
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Extracellular production of singlet oxygen by stimulated macrophages quantified using 9,10-diphenylanthracene and perylene in a polystyrene film by STEINBECK, M. J, KHAN, A. U, KARNOVSKY, M. J

“…The extracellular production of singlet oxygen (O2(1 delta g)) by stimulated macrophages was measured using a modification of our quantitative method initially…”
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Effect of Controlled Adventitial Heparin Delivery on Smooth Muscle Cell Proliferation Following Endothelial Injury by Edelman, Elazer R., Adams, David H., Karnovsky, Morris J.

“…Continuous intravenous infusion of heparin suppresses smooth muscle cell proliferation in rats after endothelial injury but may lead to hemorrhage and other…”
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Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries by Edelman, E R, Nugent, M A, Smith, L T, Karnovsky, M J

“…Basic fibroblast growth factor (bFGF) is mitogenic for smooth muscle cells (SMC) and angiogenic. We examined the in vivo effects of bFGF in balloon denuded…”
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Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells by OTTLINGER, M. E, PUKAC, L. A, KARNOVSKY, M. J

“…Heparin is potently antiproliferative for vascular smooth muscle cells in vivo and in vitro, inhibiting early proto-oncogene expression and blocking…”
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Early and Persistent Induction of Monocyte Chemoattractant Protein 1 in Rat Cardiac Allografts by Russell, Mary E., Adams, David H., Wyner, Lauri R., Yamashita, Yukari, Halnon, Nancy J., Karnovsky, Morris J.

“…The early response gene for monocyte chemoattractant protein 1 (MCP-1) encodes a potent chemotactic factor that is specific for monocytes. To determine whether…”
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Vascular Cell-Derived Heparan Sulfate Shows Coupled Inhibition of Basic Fibroblast Growth Factor Binding and Mitogenesis in Vascular Smooth Muscle Cells by Nugent, Matthew A, Karnovsky, Morris J, Edelman, Elazer R

“…Basic fibroblast growth factor (bFGF) has been previously shown to be mitogenic for vascular smooth muscle cells (VSMCs) in vivo, but only after vascular…”
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Chronic Cardiac Rejection: Identification of Five Upregulated Genes in Transplanted Hearts by Differential mRNA Display by Utans, Ulrike, Liang, Peng, Wyner, Lauri R., Karnovsky, Morris J., Russell, Mary E.

“…Transplant arteriosclerosis, the major manifestation of chronic rejection, develops after allogeneic (Lewis to F344) but not syngeneic (Lewis to Lewis) rat…”
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Heparin Selectively Inhibits a Protein Kinase C-Dependent Mechanism of Cell Cycle Progression in Calf Aortic Smooth Muscle Cells by Castellot, John J., Pukac, Laurel A., Caleb, Benjaman L., Wright, Thomas C., Karnovsky, Morris J.

“…The proliferation of arterial smooth muscle cells (SMCs) plays a critical role in the pathogenesis of arteriosclerosis. Previous studies have indicated that…”
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Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection by Russell, M E, Wallace, A F, Hancock, W W, Sayegh, M H, Adams, D H, Sibinga, N E, Wyner, L R, Karnovsky, M J

“…Lewis-to-F344 rat cardiac allografts develop chronic rejection and arteriosclerotic lesions rich in mononuclear cells (especially macrophages). This study was…”
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Mechanisms underlying transition from acute glomerular injury to late glomerular sclerosis in a rat model of nephrotic syndrome by ANDERSON, S, DIAMOND, J. R, KARNOVSKY, M. J, BRENNER, B. M

“…Functional and morphologic measurements were performed in Munich-Wistar rats after a single central venous injection of puromycin aminonucleoside (PA) or…”
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Ultrastructural localization of several phosphatases with cerium by Robinson, JM, Karnovsky, MJ

“…Cerium ions have been used as the capture agent for inorganic phosphate released during the enzymatic hydrolysis of phosphate-containing substrates by a…”
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Contrasting effects of the intermittent and continuous administration of heparin in experimental restenosis by EDELMAN, E. R, KARNOVSKY, M. J

“…Heparin inhibits proliferation of smooth muscle cells in culture and intimal hyperplasia in experimental animals but paradoxically exacerbates vascular injury…”
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A role for oxygen free radicals in aminonucleoside nephrosis by Diamond, Jonathan R., Bonventre, Joseph V., Karnovsky, Morris J.

“…A role for oxygen free radicals in aminonucleoside nephrosis. The cellular processes responsible for the proteinuria induced by the aminonucleoside of…”
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Heparin Suppresses the Induction of c-fos and c-myc mRNA in Murine Fibroblasts by Selective Inhibition of a Protein Kinase C-Dependent Pathway by Wright, Thomas C., Pukac, Laurie A., Castellot, John J., Karnovsky, Morris J., Levine, Roy A., Kim-Park, Hee-Young, Campisi, Judith

“…Heparin is a complex glycosaminoglycan that inhibits the proliferation of several cell types in culture and in vivo. To begin to define the mechanism(s) by…”
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Experimental graft arteriosclerosis. II. Immunocytochemical analysis of lesion development by Adams, D H, Wyner, L R, Karnovsky, M J

“…The development of progressive graft arteriosclerosis causes the majority of late deaths occurring in cardiac transplant recipients. The pathogenesis of this…”
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