Search Results - "M E, Gershwin"

The microbiome and autoimmunity: a paradigm from the gut–liver axis by Li, Bo, Selmi, Carlo, Tang, Ruqi, Gershwin, M E, Ma, Xiong

“…Microbial cells significantly outnumber human cells in the body, and the microbial flora at mucosal sites are shaped by environmental factors and, less…”
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Pathogen infections and primary biliary cholangitis by Tanaka, A., Leung, P. S. C., Gershwin, M. E.

“…Summary Primary biliary cholangitis (PBC) is a multi‐factorial disease caused by the interaction of both genetic predisposition and environmental triggers…”
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Complex regional pain syndrome: A comprehensive and critical review by Borchers, A.T, Gershwin, M.E

“…Abstract Complex regional pain syndrome (CRPS) is a term used to describe a variety of disorders characterized by spontaneous or stimulus-induced pain that is…”
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Serum microRNAs as novel biomarkers for primary sclerosing cholangitis and cholangiocarcinoma by Bernuzzi, F., Marabita, F., Lleo, A., Carbone, M., Mirolo, M., Marzioni, M., Alpini, G., Alvaro, D., Boberg, K. M., Locati, M., Torzilli, G., Rimassa, L., Piscaglia, F., He, X.‐S., Bowlus, C. L., Yang, G.‐X., Gershwin, M. E., Invernizzi, P.

“…Summary The diagnosis of primary sclerosing cholangitis (PSC) is difficult due to the lack of sensitive and specific biomarkers, as is the early diagnosis of…”
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The geoepidemiology of type 1 diabetes by Borchers, Andrea T, Uibo, Raivo, Gershwin, M.E

“…Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by absolute insulin deficiency resulting from the progressive immune-mediated…”
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X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma by Selmi, C., Feghali‐Bostwick, C. A., Lleo, A., Lombardi, S. A., De Santis, M., Cavaciocchi, F., Zammataro, L., Mitchell, M. M., LaSalle, J. M., Medsger Jr, T., Gershwin, M. E.

“…Summary Scleroderma (SSc) is a rare connective tissue disease characterized by fibrosis, microvasculopathy and autoimmune features. The role of genetics is…”
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Anti‐CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis by Tanaka, H., Yang, G.‐X., Iwakoshi, N., Knechtle, S. J., Kawata, K., Tsuneyama, K., Leung, P., Coppel, R. L., Ansari, A. A., Joh, T., Bowlus, C., Gershwin, M. E.

“…Summary While there have been significant advances in our understanding of the autoimmune responses and the molecular nature of the target autoantigens in…”
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The multi‐hit hypothesis of primary biliary cirrhosis: polyinosinic‐polycytidylic acid (poly I:C) and murine autoimmune cholangitis by Ambrosini, Y. M., Yang, G.‐X., Zhang, W., Tsuda, M., Shu, S., Tsuneyama, K., Leung, P. S. C., Ansari, A. A., Coppel, R. L., Gershwin, M. E.

“…Summary A void in understanding primary biliary cirrhosis (PBC) is the absence of appropriate animal models. Our laboratory has studied a murine model of…”
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Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis by Barak, V, Selmi, C, Schlesinger, M, Blank, M, Agmon-Levin, N, Kalickman, I, Gershwin, M.E, Shoenfeld, Y

“…Abstract Primary biliary cirrhosis (PBC) is a chronic cholestatic autoimmune liver disease characterized by selective destruction of the intrahepatic bile…”
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Innate immunity drives xenobiotic‐induced murine autoimmune cholangitis by Chang, C.‐H., Chen, Y.‐C., Yu, Y.‐H., Tao, M.‐H., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., Chuang, Y.‐H.

“…Summary Although primary biliary cirrhosis (PBC) is considered a model autoimmune disease, it has not responded therapeutically to traditional…”
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Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization by Wakabayashi, K, Yoshida, K, Leung, P.S.C, Moritoki, Y, Yang, G.-X, Tsuneyama, K, Lian, Z.-X, Hibi, T, Ansari, A.A, Wicker, L.S, Ridgway, W.M, Coppel, R.L, Mackay, I.R, Gershwin, M.E

“…Our laboratory has suggested that loss of tolerance to pyruvate dehydrogenase (PDC-E2) leads to an anti-mitochondrial antibody response and autoimmune…”
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Escherichia coli infection induces autoimmune cholangitis and anti‐mitochondrial antibodies in non‐obese diabetic (NOD).B6 (Idd10/Idd18) mice by Wang, J. J., Yang, G.‐X., Zhang, W. C., Lu, L., Tsuneyama, K., Kronenberg, M., Véla, J. L., Lopez‐Hoyos, M., He, X.‐S., Ridgway, W. M., Leung, P. S. C., Gershwin, M. E.

“…Summary Several epidemiological studies have demonstrated that patients with primary biliary cirrhosis (PBC) have a higher incidence of urinary tract…”
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Modulation of CD4+ T cell responses following splenectomy in hepatitis C virus‐related liver cirrhosis by Hashimoto, N., Shimoda, S., Kawanaka, H., Tsuneyama, K., Uehara, H., Akahoshi, T., Kinjo, N., Taketomi, A., Shirabe, K., Akashi, K., Lleo, A., Ansari, A. A., Gershwin, M. E., Maehara, Y.

“…Summary Dysfunction of T cells is a common feature in chronic persistent viral infections, including hepatitis C virus (HCV), and although hepatic and…”
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Epitope‐specific anti‐nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine‐dependent by Yang, C‐Y., Leung, P. S. C., Yang, G‐X., Kenny, T. P., Zhang, W., Coppel, R., Norman, G. L., Ansari, A. A., Mackay, I. R., Worman, H. J., Gershwin, M. E.

“…Summary Although the hallmark of primary biliary cirrhosis (PBC) is the presence of anti‐mitochondrial antibodies (AMA), a significant number of patients have…”
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Extracellular vesicles microRNA analysis in type 1 autoimmune pancreatitis: Increased expression of microRNA-21 by Nakamaru, Koh, Tomiyama, Takashi, Kobayashi, Sanshiro, Ikemune, Manami, Tsukuda, Satoshi, Ito, Takashi, Tanaka, Toshihiro, Yamaguchi, Takashi, Ando, Yugo, Ikeura, Tsukasa, Fukui, Toshiro, Nishio, Akiyoshi, Takaoka, Makoto, Uchida, Kazushige, Leung, Patrick S.C., Gershwin, M.E., Okazaki, Kazuichi

“…The molecular basis of type 1 autoimmune pancreatitis (AIP) remains unclear. Recent attention on the role of extracellular vesicles microRNA (EV miRNA) in…”
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Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals by Mayer, C.T, Tian, L, Hesse, C, Kühl, A.A, Swallow, M, Kruse, F, Thiele, M, Gershwin, M.E, Liston, A, Sparwasser, T

“…Abstract A major concept in autoimmunity is that disruption of Foxp3+ regulatory T cells (Tregs) predisposes to breach of tolerance. This is exemplified by the…”
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The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis by Shimoda, S., Tsuneyama, K., Kikuchi, K., Harada, K., Nakanuma, Y., Nakamura, M., Ishibashi, H., Hisamoto, S., Niiro, H., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., Akashi, K.

“…Summary One of the major obstacles in dissecting the mechanism of pathology in human primary biliary cirrhosis (PBC) has been the absence of animal models. Our…”
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T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis by Allina, Jorge, Hu, Bin, Sullivan, Daniel M., Fiel, Maria Isabel, Thung, Swan N., Bronk, Steven F., Huebert, Robert C., van de Water, Judy, LaRusso, Nicholas F., Gershwin, M.E., Gores, Gregory J., Odin, Joseph A.

“…Primary biliary cirrhosis (PBC) is characterized by loss of tolerance against ubiquitously expressed mitochondrial autoantigens followed by biliary and…”
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Endogenous interleukin‐22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice by Yang, G.‐X., Sun, Y., Tsuneyama, K., Zhang, W., Leung, P. S. C., He, X.‐S., Ansari, A. A., Bowlus, C., Ridgway, W. M., Gershwin, M. E.

“…Summary During chronic inflammation, interleukin (IL)‐22 expression is up‐regulated in both CD4 and CD8 T cells, exerting a protective role in infections…”
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Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C by Sumida, K., Shimoda, S., Iwasaka, S., Hisamoto, S., Kawanaka, H., Akahoshi, T., Ikegami, T., Shirabe, K., Shimono, N., Maehara, Y., Selmi, C., Gershwin, M. E., Akashi, K.

“…Summary There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection…”
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