Search Results - "M Carver, Chase"

Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons by Zhang, Jie, Carver, Chase M., Choveau, Frank S., Shapiro, Mark S.

“…The fidelity of neuronal signaling requires organization of signaling molecules into macromolecular complexes, whose components are in intimate proximity. The…”
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Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance by Zhang, Xu, Pearsall, Vesselina M., Carver, Chase M., Atkinson, Elizabeth J., Clarkson, Benjamin D. S., Grund, Ethan M., Baez-Faria, Michelle, Pavelko, Kevin D., Kachergus, Jennifer M., White, Thomas A., Johnson, Renee K., Malo, Courtney S., Gonzalez-Suarez, Alan M., Ayasoufi, Katayoun, Johnson, Kurt O., Tritz, Zachariah P., Fain, Cori E., Khadka, Roman H., Ogrodnik, Mikolaj, Jurk, Diana, Zhu, Yi, Tchkonia, Tamara, Revzin, Alexander, Kirkland, James L., Johnson, Aaron J., Howe, Charles L., Thompson, E. Aubrey, LeBrasseur, Nathan K., Schafer, Marissa J.

“…Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In the aged brain, senescent cell identities and the mechanisms by…”
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Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, “M-type”) K+ currents in neurons by Vigil, Fabio A, Bozdemir, Eda, Bugay, Vladislav, Chun, Sang H, Hobbs, MaryAnn, Sanchez, Isamar, Hastings, Shayne D, Veraza, Rafael J, Holstein, Deborah M, Sprague, Shane M, M Carver, Chase, Cavazos, Jose E, Brenner, Robert, Lechleiter, James D, Shapiro, Mark S

“…Nearly three million people in the USA suffer traumatic brain injury (TBI) yearly; however, there are no pre- or post-TBI treatment options available. KCNQ2-5…”
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Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury by Carver, Chase M., DeWitt, Haley R., Stoja, Aiola P., Shapiro, Mark S.

“…We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7…”
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Downregulation of KCNMB4 expression and changes in BK channel subtype in hippocampal granule neurons following seizure activity by Whitmire, Luke E, Ling, Ling, Bugay, Vladslav, Carver, Chase M, Timilsina, Santosh, Chuang, Hui-Hsiu, Jaffe, David B, Shapiro, Mark S, Cavazos, Jose E, Brenner, Robert

“…A major challenge is to understand maladaptive changes in ion channels that sets neurons on a course towards epilepsy development. Voltage- and…”
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An optimized mouse parabiosis protocol for investigation of aging and rejuvenative mechanisms by Rodriguez, Sonia L, Carver, Chase M, Dosch, Andrew J, Huffman, Derek M, Duke Boynton, Felicia D, Ayasoufi, Katayoun, Schafer, Marissa J

“…Surgical parabiosis enables sharing of the circulating milieu between two organisms. This powerful model presents diverse complications based on age, strain,…”
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Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells by Carver, Chase M, Shapiro, Mark S

“…KCNQ (Kv7, "M-type") K channels and TRPC (transient receptor potential, "canonical") cation channels are coupled to neuronal discharge properties and are…”
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Junctophilin‐4 facilitates inflammatory signalling at plasma membrane‐endoplasmic reticulum junctions in sensory neurons by Hogea, Alexandra, Shah, Shihab, Jones, Frederick, Carver, Chase M., Hao, Han, Liang, Ce, Huang, Dongyang, Du, Xiaona, Gamper, Nikita

“…Key points Rat somatosensory neurons express a junctional protein, junctophilin‐4 (JPH4) JPH4 is necessary for the formation of store operated Ca2+ entry…”
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Pharmacological Manipulation of Kv7 Channels as a New Therapeutic Tool for Multiple Brain Disorders by Vigil, Fabio A., Carver, Chase M., Shapiro, Mark S.

“…K v 7 (“M-type,” KCNQ) K + currents, play dominant roles in controlling neuronal excitability. They act as a “brake” against hyperexcitable states in the…”
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Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC by Archer, Crystal R., Enslow, Benjamin T., Carver, Chase M., Stockand, James D.

“…The plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) regulates the activity of diverse ion channels to include the epithelial Na+…”
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Functional responses of the hippocampus to hyperexcitability depend on directed, neuron‐specific KCNQ2 K+ channel plasticity by Carver, Chase M., Hastings, Shayne D., Cook, Mileah E., Shapiro, Mark S.

“…M‐type (KCNQ2/3) K+ channels play dominant roles in regulation of active and passive neuronal discharge properties such as resting membrane potential,…”
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SenNet recommendations for detecting senescent cells in different tissues by Suryadevara, Vidyani, Hudgins, Adam D, Rajesh, Adarsh, Pappalardo, Alberto, Karpova, Alla, Dey, Amit K, Hertzel, Ann, Agudelo, Anthony, Rocha, Azucena, Soygur, Bikem, Schilling, Birgit, Carver, Chase M, Aguayo-Mazzucato, Cristina, Baker, Darren J, Bernlohr, David A, Jurk, Diana, Mangarova, Dilyana B, Quardokus, Ellen M, Enninga, Elizabeth Ann L, Schmidt, Elizabeth L, Chen, Feng, Duncan, Francesca E, Cambuli, Francesco, Kaur, Gagandeep, Kuchel, George A, Lee, Gung, Daldrup-Link, Heike E, Martini, Helene, Phatnani, Hemali, Al-Naggar, Iman M, Rahman, Irfan, Nie, Jia, Passos, João F, Silverstein, Jonathan C, Campisi, Judith, Wang, Julia, Iwasaki, Kanako, Barbosa, Karina, Metis, Kay, Nernekli, Kerem, Niedernhofer, Laura J, Ding, Li, Wang, Lichao, Adams, Lisa C, Ruiyang, Liu, Doolittle, Madison L, Teneche, Marcos G, Schafer, Marissa J, Xu, Ming, Hajipour, Mohammadjavad, Boroumand, Mozhgan, Basisty, Nathan, Sloan, Nicholas, Slavov, Nikolai, Kuksenko, Olena, Robson, Paul, Gomez, Paul T, Vasilikos, Periklis, Adams, Peter D, Carapeto, Priscila, Zhu, Quan, Ramasamy, Ramalakshmi, Perez-Lorenzo, Rolando, Fan, Rong, Dong, Runze, Montgomery, Ruth R, Shaikh, Sadiya, Vickovic, Sanja, Yin, Shanshan, Kang, Shoukai, Suvakov, Sonja, Khosla, Sundeep, Garovic, Vesna D, Menon, Vilas, Xu, Yanxin, Song, Yizhe, Suh, Yousin, Dou, Zhixun, Neretti, Nicola

“…Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and…”
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Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype by Grant, Corena V., Carver, Chase M., Hastings, Shayne D., Ramachandran, Karthik, Muniswamy, Madesh, Risinger, April L., Beutler, John A., Mooberry, Susan L.

“…Purpose Triple-negative breast cancers (TNBCs) represent a heterogeneous group of tumors. The lack of targeted therapies combined with the inherently…”
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Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome by Gao, Ashley Y, Diaz Espinosa, Ana M, Gianì, Fiorenza, Pham, Tho X, Carver, Chase M, Aravamudhan, Aja, Bartman, Colleen M, Ligresti, Giovanni, Caporarello, Nunzia, Schafer, Marissa J, Haak, Andrew J

“…Cellular senescence is emerging as a driver of idiopathic pulmonary fibrosis (IPF), a progressive and fatal disease with limited effective therapies. The…”
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Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain by Gomez, Paul T., Carver, Chase M., Rodriguez, Sonia L., Wang, Liguo, Zhang, Xu, Schafer, Marissa J.

“…Age-related changes in oligodendrocyte precursor cells (OPCs) contribute to white matter dysfunction. In aged mice, we hypothesized that myelin-dense fimbria…”
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Muscarinic Receptor Neuromodulation of KCNQ M-Type K+, and Other, Channels in Hippocampal Principal Neurons Involves Striking Cell-Specific Regulation Controlling Excitability by Carver, Chase M., Shapiro, Mark S.

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GQ/11-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 “M-Type” K+ Channels and Activation of TRPC Cation Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Neurons in Hippocampus by Carver, Chase M., Hastings, Shayne D., Shapiro, Mark S.

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PIP 2 Binds Multiple Cationic Sites of ENaC by Archer, Crystal R., Carver, Chase M., Enslow, Benjamin T., Stockand, James D.

“…Abstract only Phosphatidylinositol 4,5‐bisphosphate (PIP 2 ) regulates the activity and gating of many different ion channels to include the epithelial Na +…”
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Nanodomain Calcium Signals Couple Activation of TRPV1 and ANO1 Sensory Ion Channels by Shah, Shihab S., Carver, Chase M., Shapiro, Mark S., Gamper, Nikita

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Pharmacological Manipulation of K v 7 Channels as a New Therapeutic Tool for Multiple Brain Disorders by Vigil, Fabio A, Carver, Chase M, Shapiro, Mark S

“…K 7 ("M-type," KCNQ) K currents, play dominant roles in controlling neuronal excitability. They act as a "brake" against hyperexcitable states in the central…”
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