Assessment of hypoxemia among young adults with sickle cell anaemia in steady state in southwestern Nigeria: a crosssectional study

Hypoxia is a known feature of sickle cell anaemia (SCA) which results from chronic anaemia and recurrent vaso-occlusive crisis (VOC) which can cause tissue ischaemia that leads to an end organ damage. The hallmark of SCA is chronic anaemia and recurrent vaso-occlusive crisis. The aim of this study i...

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Bibliographic Details
Published in:	BMC research notes Vol. 17; no. 1; p. 100
Main Authors:	M A, Asafa, O, Ahmed I, M S, Afolabi, A, Bolarinwa R, O, Ogunlade
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 08-04-2024 BioMed Central BMC
Subjects:	Age Analysis Anemia Anemia, Sickle Cell - complications Anemia, Sickle Cell - epidemiology Asthma Blood transfusions Complications and side effects Cross-Sectional Studies Demographic aspects Female Females Hematology Hemoglobin Humans Hypoxemia Hypoxia Hypoxia - epidemiology Ischemia Lung diseases Male Males Medical examination Nigeria - epidemiology Oxygen saturation Pediatrics Pulse oximetry Research Note Risk factors Sickle cell anaemia Sickle cell anemia Sickle cell disease Steady state Teenagers Vaso-occlusive crisis Young Adult Young adults Youth Nigeria Vaso-occlusive crisis Hypoxemia Sickle cell anaemia Steady state
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Summary:	Hypoxia is a known feature of sickle cell anaemia (SCA) which results from chronic anaemia and recurrent vaso-occlusive crisis (VOC) which can cause tissue ischaemia that leads to an end organ damage. The hallmark of SCA is chronic anaemia and recurrent vaso-occlusive crisis. The aim of this study is to compare the oxygen saturation of sickle cell anaemic individuals with the normal haemoglobin type (Hb AA) control and also to determine the prevalence of hypoxemia among SCA. Two-hundred and twenty-two (136 Hb SS and 86 Hb AA) participated in the study. The mean ± SD of age (years), oxygen saturation (%) and pulse rate (bpm) of participants with sickle cell anaemia and Hb AA control were 21.85 ± 3.04 and 22.14 ± 3.18 (t = 0.701, p = 0.436), 95.21 ± 3.02 and 98.07 ± 0.81 (t=-8.598, p < 0.0001) and 77.10 ± 9.28 and 73.16 ± 8.52 (t = 3.173, p = 0.002) respectively. The prevalence of hypoxemia among SCA participants was 47.1%. Prevalence of hypoxemia in males with SCA was 60.9% while 39.1% of the females had hypoxemia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1756-0500 1756-0500
DOI:	10.1186/s13104-024-06765-0