Normal values for thrombelastography (ROTEM®) and selected coagulation parameters in porcine blood

Normal values for thrombelastography (ROTEM®) and selected coagulation parameters in porcine blood

The pig is a suitable animal model for researching blood coagulation and fibrinolysis. The present study therefore aimed to investigate in porcine blood the applicability of commercially available tests of coagulation and thrombelastography (ROTEM®) and above all to determine normal values for coagu...

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Bibliographic Details
Published in:Thrombosis research Vol. 117; no. 5; pp. 597 - 602
Main Authors: Velik-Salchner, Corinna, Schnürer, Christian, Fries, Dietmar, Müssigang, Peter R., Moser, Patrizia L., Streif, Werner, Kolbitsch, Christian, Lorenz, Ingo H.
Format: Journal Article
Language:English
Published: New York, NY Elsevier Ltd 2006
Elsevier Science
Subjects:
Animals
Biological and medical sciences
Blood and lymphatic vessels
Blood Coagulation - drug effects
Blood Coagulation Tests
Brain
Cardiology. Vascular system
Cardiovascular system
Coagulation parameters
Cytochalasin D - pharmacology
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Dose-Response Relationship, Drug
Human test kit
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Models, Animal
Modified thrombelastography (ROTEM®)
Normal values
Pigs
Reference Values
Swine
Thrombelastography - methods
Ultrasonic investigative techniques
Pigs
Normal values
Human test kit
Modified thrombelastography (ROTEM®)
Coagulation parameters
Blood coagulation
Animal model
Hemostatic
Cardiovascular disease
Thrombin
Anticoagulant
Prothrombin time
Antithrombin III
Fibrinogen
Partial thromboplastin time
Ungulata
Human
Serine endopeptidases
Enzyme
Enzyme inhibitor
Protein C
D dimer
Fibrinolysis
Pig
Peptidases
Vertebrata
Mammalia
Hydrolases
Artiodactyla
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Summary:The pig is a suitable animal model for researching blood coagulation and fibrinolysis. The present study therefore aimed to investigate in porcine blood the applicability of commercially available tests of coagulation and thrombelastography (ROTEM®) and above all to determine normal values for coagulation parameters (e.g. prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin-antithrombin complexes (TAT), fibrinogen, antithrombin III (AT III), D-dimers, protein C). Except for the FibTEM® and aPTT tests, all commercially available coagulation tests used were fully applicable for porcine blood. Normal values and reference intervals for porcine blood are given. As compared to the human reference intervals for the coagulation parameters investigated, porcine blood was found to be hypercoagulable.
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ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2005.05.015