Search Results - "Müller, Ulrike C"

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis by Strilic, Boris, Yang, Lida, Albarrán-Juárez, Julián, Wachsmuth, Laurens, Han, Kang, Müller, Ulrike C., Pasparakis, Manolis, Offermanns, Stefan

“…Human and murine tumour cells induce programmed necrosis (necroptosis) of endothelial cells, which promotes tumour cell extravasation and metastasis. Tumour…”
Get full text

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome by Pasciuto, Emanuela, Ahmed, Tariq, Wahle, Tina, Gardoni, Fabrizio, D’Andrea, Laura, Pacini, Laura, Jacquemont, Sébastien, Tassone, Flora, Balschun, Detlef, Dotti, Carlos G., Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Müller, Ulrike C., Di Luca, Monica, De Strooper, Bart, Bagni, Claudia

“…The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The…”
Get full text

The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior by Klevanski, Maja, Herrmann, Ulrike, Weyer, Sascha W, Fol, Romain, Cartier, Nathalie, Wolfer, David P, Caldwell, John H, Korte, Martin, Müller, Ulrike C

“…The amyloid precursor protein family (APP/APLPs) has essential roles for neuromuscular synapse development and for the formation and plasticity of synapses…”
Get full text

Functions of the APP gene family in the nervous system: insights from mouse models by Aydin, Dorothee, Weyer, Sascha W., Müller, Ulrike C.

“…The amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer’s disease (AD), as proteolytical cleavage of APP gives rise to the…”
Get full text

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis by Zou, Chengyu, Crux, Sophie, Marinesco, Stephane, Montagna, Elena, Sgobio, Carmelo, Shi, Yuan, Shi, Song, Zhu, Kaichuan, Dorostkar, Mario M, Müller, Ulrike C, Herms, Jochen

“…Dynamic synapses facilitate activity‐dependent remodeling of neural circuits, thereby providing the structural substrate for adaptive behaviors. However, the…”
Get full text

Impaired theta-gamma coupling in APP-deficient mice by Zhang, Xiaomin, Zhong, Wewei, Brankačk, Jurij, Weyer, Sascha W., Müller, Ulrike C., Tort, Adriano B. L., Draguhn, Andreas

“…Amyloid precursor protein (APP) is critically involved in the pathophysiology of Alzheimer’s disease, but its physiological functions remain elusive…”
Get full text

APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission by Schilling, Sandra, Mehr, Annika, Ludewig, Susann, Stephan, Jonathan, Zimmermann, Marius, August, Alexander, Strecker, Paul, Korte, Martin, Koo, Edward H, Müller, Ulrike C, Kins, Stefan, Eggert, Simone

“…The amyloid precursor protein (APP), a key player in Alzheimer's disease, belongs to the family of synaptic adhesion molecules (SAMs) due to its impact on…”
Get full text

APPsα Rescues Tau-Induced Synaptic Pathology by Bold, Charlotte S, Baltissen, Danny, Ludewig, Susann, Back, Michaela K, Just, Jennifer, Kilian, Lara, Erdinger, Susanne, Banicevic, Marija, Rehra, Lena, Almouhanna, Fadi, Nigri, Martina, Wolfer, David P, Spilger, Roman, Rohr, Karl, Kann, Oliver, Buchholz, Christian J, von Engelhardt, Jakob, Korte, Martin, Müller, Ulrike C

“…Alzheimer's disease (AD) is histopathologically characterized by Aβ plaques and the accumulation of hyperphosphorylated Tau species, the latter also…”
Get full text

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP by Weyer, Sascha W, Klevanski, Maja, Delekate, Andrea, Voikar, Vootele, Aydin, Dorothee, Hick, Meike, Filippov, Mikhail, Drost, Natalia, Schaller, Kristin L, Saar, Martina, Vogt, Miriam A, Gass, Peter, Samanta, Ayan, Jäschke, Andres, Korte, Martin, Wolfer, David P, Caldwell, John H, Müller, Ulrike C

“…Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and its proteolytic fragments are still…”
Get full text

Differential role of APP and APLPs for neuromuscular synaptic morphology and function by Klevanski, Maja, Saar, Martina, Baumkötter, Frederik, Weyer, Sascha W., Kins, Stefan, Müller, Ulrike C.

“…The analysis of mouse models indicated that APP and the related APLPs are important for synapse formation and function. The synaptic role of APP is, however,…”
Get full text

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model by Rice, Heather C, Marcassa, Gabriele, Chrysidou, Iordana, Horré, Katrien, Young-Pearse, Tracy L, Müller, Ulrike C, Saito, Takashi, Saido, Takaomi C, Vassar, Robert, de Wit, Joris, De Strooper, Bart

“…The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer's disease (AD) brains, is derived from sequential proteolytic…”
Get full text

APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice by Baltissen, Danny, Bold, Charlotte S, Rehra, Lena, Banićević, Marija, Fricke, Justus, Just, Jennifer, Ludewig, Susann, Buchholz, Christian J, Korte, Martin, Müller, Ulrike C

“…The Tau protein can be phosphorylated by numerous kinases. In Alzheimer's disease (AD) hyperphosphorylated Tau species accumulate as neurofibrillary tangles…”
Get full text

Editorial: The Physiological Functions of the APP Gene Family by Müller, Ulrike C, Deller, Thomas

“…[...]expression changes over time and with aging add additional levels of complexity. [...]understanding APP gene family functions is challenging and this…”
Get full text

APP family member dimeric complexes are formed predominantly in synaptic compartments by Schilling, Sandra, August, Alexander, Meleux, Mathieu, Conradt, Carolin, Tremmel, Luisa M, Teigler, Sandra, Adam, Virginie, Müller, Ulrike C, Koo, Edward H, Kins, Stefan, Eggert, Simone

“…The amyloid precursor protein (APP), a key player in Alzheimer's disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and…”
Get full text

Lack of APLP1 leads to subtle alterations in neuronal morphology but does not affect learning and memory by Erdinger, Susanne, Amrein, Irmgard, Back, Michaela, Ludewig, Susann, Korte, Martin, von Engelhardt, Jakob, Wolfer, David P., Müller, Ulrike C.

“…The amyloid precursor protein APP plays a crucial role in Alzheimer pathogenesis. Its physiological functions, however, are only beginning to be unraveled. APP…”
Get full text

Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus by Vnencak, Matej, Paul, Mandy H., Hick, Meike, Schwarzacher, Stephan W., Del Turco, Domenico, Müller, Ulrike C., Deller, Thomas, Jedlicka, Peter

“…Amyloid precursor‐like protein 1 (APLP1) is a transmembrane synaptic protein belonging to the amyloid precursor protein (APP) gene family. Although the role of…”
Get full text

Not just amyloid: physiological functions of the amyloid precursor protein family by Müller, Ulrike C., Deller, Thomas, Korte, Martin

“…Key Points Amyloid precursor protein (APP) and the APP-like proteins APLP1 and APLP2 form the mammalian APP gene family. They have important physiological…”
Get full text

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice by Frank, Stefanie, Copanaki, Ekaterini, Burbach, Guido J., Müller, Ulrike C., Deller, Thomas

“…Alzheimer's disease (AD) is characterized by the pathological deposition of amyloid-β protein in the aged brain. Inefficient clearance of amyloid-β from brain…”
Get full text

Hippocampal network oscillations in APP/APLP2-deficient mice by Zhang, Xiaomin, Herrmann, Ulrike, Weyer, Sascha W, Both, Martin, Müller, Ulrike C, Korte, Martin, Draguhn, Andreas

“…The physiological function of amyloid precursor protein (APP) and its two homologues APP-like protein 1 (APLP1) and 2 (APLP2) is largely unknown. Previous work…”
Get full text

CNTN4 modulates neural elongation through interplay with APP by Bamford, Rosemary A, Zuko, Amila, Eve, Madeline, Sprengers, Jan J, Post, Harm, Taggenbrock, Renske L R E, Fäβler, Dominique, Mehr, Annika, Jones, Owen J R, Kudzinskas, Aurimas, Gandawijaya, Josan, Müller, Ulrike C, Kas, Martien J H, Burbach, J Peter H, Oguro-Ando, Asami

“…The neuronal cell adhesion molecule contactin-4 ( ) is genetically associated with autism spectrum disorder (ASD) and other psychiatric disorders. -deficient…”
Get full text