Search Results - "Müller, Timo D."

GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications by Campbell, Jonathan E, Müller, Timo D, Finan, Brian, DiMarchi, Richard D, Tschöp, Matthias H, D'Alessio, David A

“…The incretin system is an essential metabolic axis that regulates postprandial metabolism. The two incretin peptides that enable this effect are the…”
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Unimolecular Polypharmacy for Treatment of Diabetes and Obesity by Tschöp, Matthias H., Finan, Brian, Clemmensen, Christoffer, Gelfanov, Vasily, Perez-Tilve, Diego, Müller, Timo D., DiMarchi, Richard D.

“…Many complex diseases have historically proven to be defiant to the best mono-therapeutic approaches. Several examples of combination therapies have largely…”
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Glucagon Regulation of Energy Expenditure by Kleinert, Maximilian, Sachs, Stephan, Habegger, Kirk M, Hofmann, Susanna M, Müller, Timo D

“…Glucagon's ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon's thermogenic effect still…”
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Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease by Niu, Lili, Geyer, Philipp E, Wewer Albrechtsen, Nicolai J, Gluud, Lise L, Santos, Alberto, Doll, Sophia, Treit, Peter V, Holst, Jens J, Knop, Filip K, Vilsbøll, Tina, Junker, Anders, Sachs, Stephan, Stemmer, Kerstin, Müller, Timo D, Tschöp, Matthias H, Hofmann, Susanna M, Mann, Matthias

“…Non‐alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes…”
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Reappraisal of GIP Pharmacology for Metabolic Diseases by Finan, Brian, Müller, Timo D, Clemmensen, Christoffer, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H

“…Glucagon-like peptide-1 (GLP-1) analogs are considered the best current medicines for type 2 diabetes (T2D) and obesity due to their actions in lowering blood…”
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Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency by Sundaram, Sivaraj M, Arrulo Pereira, Adriana, Müller-Fielitz, Helge, Köpke, Hannes, De Angelis, Meri, Müller, Timo D, Heuer, Heike, Körbelin, Jakob, Krohn, Markus, Mittag, Jens, Nogueiras, Ruben, Prevot, Vincent, Schwaninger, Markus

“…A genetic deficiency of the solute carrier monocarboxylate transporter 8 (MCT8), termed Allan-Herndon-Dudley syndrome, is an important cause of X-linked…”
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Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes by Tan, Qiming, Akindehin, Seun E, Orsso, Camila E, Waldner, Richelle C, DiMarchi, Richard D, Müller, Timo D, Haqq, Andrea M

“…The incretin hormone glucagon-like peptide-1 (GLP-1) has received enormous attention during the past three decades as a therapeutic target for the treatment of…”
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Transfer of Proteins from Cultured Human Adipose to Blood Cells and Induction of Anabolic Phenotype Are Controlled by Serum, Insulin and Sulfonylurea Drugs by Müller, Günter A, Müller, Timo D

“…Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer leaflet of eukaryotic plasma membranes (PMs) only by carboxy-terminal…”
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Biological Role of the Intercellular Transfer of Glycosylphosphatidylinositol-Anchored Proteins: Stimulation of Lipid and Glycogen Synthesis by Müller, Günter A, Müller, Timo D

“…Glycosylphosphatidylinositol-anchored proteins (GPI-APs), which are anchored at the outer leaflet of plasma membranes (PM) only by a carboxy-terminal GPI…”
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Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis by Yu, Qiang, Gamayun, Igor, Wartenberg, Philipp, Zhang, Qian, Qiao, Sen, Kusumakshi, Soumya, Candlish, Sarah, Götz, Viktoria, Wen, Shuping, Das, Debajyoti, Wyatt, Amanda, Wahl, Vanessa, Ectors, Fabien, Kattler, Kathrin, Yildiz, Daniela, Prevot, Vincent, Schwaninger, Markus, Ternier, Gaetan, Giacobini, Paolo, Ciofi, Philippe, Müller, Timo D., Boehm, Ulrich

“…The median eminence (ME) is a circumventricular organ at the base of the brain that controls body homeostasis. Tanycytes are its specialized glial cells that…”
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Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo by Kulaj, Konxhe, Harger, Alexandra, Bauer, Michaela, Caliskan, Özüm S., Gupta, Tilak Kumar, Chiang, Dapi Menglin, Milbank, Edward, Reber, Josefine, Karlas, Angelos, Kotzbeck, Petra, Sailer, David N., Volta, Francesco, Lutter, Dominik, Prakash, Sneha, Merl-Pham, Juliane, Ntziachristos, Vasilis, Hauner, Hans, Pfaffl, Michael W., Tschöp, Matthias H., Müller, Timo D., Hauck, Stefanie M., Engel, Benjamin D., Gerdes, Jantje M., Pfluger, Paul T., Krahmer, Natalie, Stemmer, Kerstin

“…Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, to delineate…”
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Revisiting the Pharmacological Value of Glucagon: An Editorial for the Special Issue "The Biology and Pharmacology of Glucagon" by Müller, Timo D, Habegger, Kirk

“…In 1921, a Canadian research team led by Frederick Banting and John Macleod succeeded in the isolation of insulin from pancreatic homogenate [...]…”
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NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ by Huang, Jianfeng, Linares, Juan F., Duran, Angeles, Xia, Wenmin, Saltiel, Alan R., Müller, Timo D., Diaz-Meco, Maria T., Moscat, Jorge

“…Activation of non-shivering thermogenesis is considered a promising approach to lower body weight in obesity. p62 deficiency in adipocytes reduces systemic…”
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Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists by Novikoff, Aaron, O'Brien, Shannon L., Bernecker, Miriam, Grandl, Gerald, Kleinert, Maximilian, Knerr, Patrick J., Stemmer, Kerstin, Klingenspor, Martin, Zeigerer, Anja, DiMarchi, Richard, Tschöp, Matthias H., Finan, Brian, Calebiro, Davide, Müller, Timo D.

“…We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including…”
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Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition by Mueller, Kristina M, Hartmann, Kerstin, Kaltenecker, Doris, Vettorazzi, Sabine, Bauer, Mandy, Mauser, Lea, Amann, Sabine, Jall, Sigrid, Fischer, Katrin, Esterbauer, Harald, Müller, Timo D, Tschöp, Matthias H, Magnes, Christoph, Haybaeck, Johannes, Scherer, Thomas, Bordag, Natalie, Tuckermann, Jan P, Moriggl, Richard

“…Glucocorticoids (GCs) are important regulators of systemic energy metabolism, and aberrant GC action is linked to metabolic dysfunctions. Yet, the extent to…”
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Targeted pharmacological therapy restores β-cell function for diabetes remission by Sachs, Stephan, Bastidas-Ponce, Aimée, Tritschler, Sophie, Bakhti, Mostafa, Böttcher, Anika, Sánchez-Garrido, Miguel A., Tarquis-Medina, Marta, Kleinert, Maximilian, Fischer, Katrin, Jall, Sigrid, Harger, Alexandra, Bader, Erik, Roscioni, Sara, Ussar, Siegfried, Feuchtinger, Annette, Yesildag, Burcak, Neelakandhan, Aparna, Jensen, Christine B., Cornu, Marion, Yang, Bin, Finan, Brian, DiMarchi, Richard D., Tschöp, Matthias H., Theis, Fabian J., Hofmann, Susanna M., Müller, Timo D., Lickert, Heiko

“…Dedifferentiation of insulin-secreting β cells in the islets of Langerhans has been proposed to be a major mechanism of β-cell dysfunction. Whether…”
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(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins I: Localization at Plasma Membranes and Extracellular Compartments by Müller, Günter A, Müller, Timo D

“…Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) are anchored at the outer leaflet of plasma membranes (PMs) of all eukaryotic organisms studied so…”
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Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice by Jall, Sigrid, Sachs, Stephan, Clemmensen, Christoffer, Finan, Brian, Neff, Frauke, DiMarchi, Richard D, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M

“…Abstract Objective Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies is…”
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Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy by Sánchez-Garrido, Miguel A., Serrano-López, Víctor, Ruiz-Pino, Francisco, Vázquez, María Jesús, Rodríguez-Martín, Andrea, Torres, Encarnación, Velasco, Inmaculada, Rodríguez, Ana Belén, Chicano-Gálvez, Eduardo, Mora-Ortiz, Marina, Ohlsson, Claes, Poutanen, Matti, Pinilla, Leonor, Gaytán, Francisco, Douros, Jonathan D., Yang, Bin, Müller, Timo D., DiMarchi, Richard D., Tschöp, Matthias H., Finan, Brian, Tena-Sempere, Manuel

“…Polycystic ovary syndrome (PCOS) is a heterogeneous condition, defined by oligo-/anovulation, hyper-androgenism and/or polycystic ovaries. Metabolic…”
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Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes by Clemmensen, Christoffer, Jall, Sigrid, Kleinert, Maximilian, Quarta, Carmelo, Gruber, Tim, Reber, Josefine, Sachs, Stephan, Fischer, Katrin, Feuchtinger, Annette, Karlas, Angelos, Simonds, Stephanie E., Grandl, Gerald, Loher, Daniela, Sanchez-Quant, Eva, Keipert, Susanne, Jastroch, Martin, Hofmann, Susanna M., Nascimento, Emmani B. M., Schrauwen, Patrick, Ntziachristos, Vasilis, Cowley, Michael A., Finan, Brian, Müller, Timo D., Tschöp, Matthias H.

“…Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity…”
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