Search Results - "Müller, Marcel A."

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19 by Hoffmann, Markus, Schroeder, Simon, Kleine-Weber, Hannah, Müller, Marcel A, Drosten, Christian, Pöhlmann, Stefan

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor by Hoffmann, Markus, Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Herrler, Tanja, Erichsen, Sandra, Schiergens, Tobias S., Herrler, Georg, Wu, Nai-Huei, Nitsche, Andreas, Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan

“…The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health…”
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Serological assays for emerging coronaviruses: Challenges and pitfalls by Meyer, Benjamin, Drosten, Christian, Müller, Marcel A.

“…•Serological studies on SARS- and MERS-coronavirus (CoV) diagnostics were reviewed.•Different types of serological assays and variable antigens were…”
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Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination by Loyal, Lucie, Braun, Julian, Henze, Larissa, Kruse, Beate, Dingeldey, Manuela, Reimer, Ulf, Kern, Florian, Schwarz, Tatjana, Mangold, Maike, Unger, Clara, Dörfler, Friederike, Kadler, Shirin, Rosowski, Jennifer, Gürcan, Kübrah, Uyar-Aydin, Zehra, Frentsch, Marco, Kurth, Florian, Schnatbaum, Karsten, Eckey, Maren, Hippenstiel, Stefan, Hocke, Andreas, Müller, Marcel A, Sawitzki, Birgit, Miltenyi, Stefan, Paul, Friedemann, Mall, Marcus A, Wenschuh, Holger, Voigt, Sebastian, Drosten, Christian, Lauster, Roland, Lachman, Nils, Sander, Leif-Erik, Corman, Victor M, Röhmel, Jobst, Meyer-Arndt, Lil, Thiel, Andreas, Giesecke-Thiel, Claudia

“…The functional relevance of preexisting cross-immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we…”
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MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997 by Müller, Marcel A, Corman, Victor Max, Jores, Joerg, Meyer, Benjamin, Younan, Mario, Liljander, Anne, Bosch, Berend-Jan, Lattwein, Erik, Hilali, Mosaad, Musa, Bakri E, Bornstein, Set, Drosten, Christian

“…To analyze the distribution of Middle East respiratory syndrome coronavirus (MERS-CoV)-seropositive dromedary camels in eastern Africa, we tested 189 archived…”
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SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection by Gassen, Nils C., Niemeyer, Daniela, Muth, Doreen, Corman, Victor M., Martinelli, Silvia, Gassen, Alwine, Hafner, Kathrin, Papies, Jan, Mösbauer, Kirstin, Zellner, Andreas, Zannas, Anthony S., Herrmann, Alexander, Holsboer, Florian, Brack-Werner, Ruth, Boshart, Michael, Müller-Myhsok, Bertram, Drosten, Christian, Müller, Marcel A., Rein, Theo

“…Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified…”
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Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform by Thi Nhu Thao, Tran, Labroussaa, Fabien, Ebert, Nadine, V’kovski, Philip, Stalder, Hanspeter, Portmann, Jasmine, Kelly, Jenna, Steiner, Silvio, Holwerda, Melle, Kratzel, Annika, Gultom, Mitra, Schmied, Kimberly, Laloli, Laura, Hüsser, Linda, Wider, Manon, Pfaender, Stephanie, Hirt, Dagny, Cippà, Valentina, Crespo-Pomar, Silvia, Schröder, Simon, Muth, Doreen, Niemeyer, Daniela, Corman, Victor M., Müller, Marcel A., Drosten, Christian, Dijkman, Ronald, Jores, Joerg, Thiel, Volker

“…Reverse genetics has been an indispensable tool to gain insights into viral pathogenesis and vaccine development. The genomes of large RNA viruses, such as…”
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Human Adaptation of Ebola Virus during the West African Outbreak by Urbanowicz, Richard A., McClure, C. Patrick, Sakuntabhai, Anavaj, Sall, Amadou A., Kobinger, Gary, Müller, Marcel A., Holmes, Edward C., Rey, Félix A., Simon-Loriere, Etienne, Ball, Jonathan K.

“…The 2013–2016 outbreak of Ebola virus (EBOV) in West Africa was the largest recorded. It began following the cross-species transmission of EBOV from an animal…”
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SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals by Gassen, Nils C., Papies, Jan, Bajaj, Thomas, Emanuel, Jackson, Dethloff, Frederik, Chua, Robert Lorenz, Trimpert, Jakob, Heinemann, Nicolas, Niemeyer, Christine, Weege, Friderike, Hönzke, Katja, Aschman, Tom, Heinz, Daniel E., Weckmann, Katja, Ebert, Tim, Zellner, Andreas, Lennarz, Martina, Wyler, Emanuel, Schroeder, Simon, Richter, Anja, Niemeyer, Daniela, Hoffmann, Karen, Meyer, Thomas F., Heppner, Frank L., Corman, Victor M., Landthaler, Markus, Hocke, Andreas C., Morkel, Markus, Osterrieder, Nikolaus, Conrad, Christian, Eils, Roland, Radbruch, Helena, Giavalisco, Patrick, Drosten, Christian, Müller, Marcel A.

“…Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and…”
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Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013 by Memish, Ziad A, Cotten, Matthew, Meyer, Benjamin, Watson, Simon J, Alsahafi, Abdullah J, Al Rabeeah, Abdullah A, Corman, Victor Max, Sieberg, Andrea, Makhdoom, Hatem Q, Assiri, Abdullah, Al Masri, Malaki, Aldabbagh, Souhaib, Bosch, Berend-Jan, Beer, Martin, Müller, Marcel A, Kellam, Paul, Drosten, Christian

“…We investigated a case of human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) after exposure to infected camels. Analysis of the whole…”
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Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study by Müller, Marcel A, PhD, Meyer, Benjamin, MSc, Corman, Victor M, MD, Al-Masri, Malak, BSc, Turkestani, Abdulhafeez, MD, Ritz, Daniel, MSc, Sieberg, Andrea, BSc, Aldabbagh, Souhaib, DVM, Bosch, Berend-J, PhD, Lattwein, Erik, PhD, Alhakeem, Raafat F, MD, Assiri, Abdullah M, MD, Albarrak, Ali M, MD, Al-Shangiti, Ali M, PhD, Al-Tawfiq, Jaffar A, MD, Wikramaratna, Paul, PhD, Alrabeeah, Abdullah A, MD, Drosten, Christian, Prof, Memish, Ziad A, Prof

“…Summary Background Scientific evidence suggests that dromedary camels are the intermediary host for the Middle East respiratory syndrome coronavirus…”
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Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response by GLOWACKA, Ilona, BERTRAM, Stephanie, NIEMEYER, Daniela, SCHNEIDER, Heike, DROSTEN, Christian, PÖHLMANN, Stefan, MÜLLER, Marcel A, ALLEN, Paul, SOILLEUX, Elizabeth, PFEFFERLE, Susanne, STEFFEN, Imke, TSEGAYE, Theodros Solomon, YUXIAN HE, GNIRSS, Kerstin

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Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study by Corman, Victor M, Haage, Verena Claudia, Bleicker, Tobias, Schmidt, Marie Luisa, Mühlemann, Barbara, Zuchowski, Marta, Jo, Wendy K, Tscheak, Patricia, Möncke-Buchner, Elisabeth, Müller, Marcel A, Krumbholz, Andi, Drexler, Jan Felix, Drosten, Christian

“…Antigen point-of-care tests (AgPOCTs) can accelerate SARS-CoV-2 testing. As some AgPOCTs have become available, interest is growing in their utility and…”
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Amplification of emerging viruses in a bat colony by Drexler, Jan Felix, Corman, Victor Max, Wegner, Tom, Tateno, Adriana Fumie, Zerbinati, Rodrigo Melim, Gloza-Rausch, Florian, Seebens, Antje, Müller, Marcel A, Drosten, Christian

“…Bats host noteworthy viral pathogens, including coronaviruses, astroviruses, and adenoviruses. Knowledge on the ecology of reservoir-borne viruses is critical…”
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Transmission of MERS-Coronavirus in Household Contacts by Drosten, Christian, Meyer, Benjamin, Müller, Marcel A, Corman, Victor M, Al-Masri, Malak, Hossain, Raheela, Madani, Hosam, Sieberg, Andrea, Bosch, Berend Jan, Lattwein, Erik, Alhakeem, Raafat F, Assiri, Abdullah M, Hajomar, Waleed, Albarrak, Ali M, Al-Tawfiq, Jaffar A, Zumla, Alimuddin I, Memish, Ziad A

“…Defining transmission dynamics of the Middle East respiratory syndrome coronavirus (MERS-CoV) is important for public health measures. In this report,…”
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Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist by Niemeyer, Daniela, Zillinger, Thomas, Muth, Doreen, Zielecki, Florian, Horvath, Gabor, Suliman, Tasnim, Barchet, Winfried, Weber, Friedemann, Drosten, Christian, Müller, Marcel A

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Mammalian deltavirus without hepadnavirus coinfection in the neotropical rodent Proechimys semispinosus by Paraskevopoulou, Sofia, Pirzer, Fabian, Goldmann, Nora, Schmid, Julian, Corman, Victor Max, Gottula, Lina Theresa, Schroeder, Simon, Rasche, Andrea, Muth, Doreen, Drexler, Jan Felix, Heni, Alexander Christoph, Eibner, Georg Joachim, Page, Rachel A., Jones, Terry C., Muller, Marcel A., Sommer, Simone, Glebe, Dieter, Drosten, Christian

“…Hepatitis delta virus (HDV) is a human hepatitis-causing RNA virus, unrelated to any other taxonomic group of RNA viruses. Its occurrence as a satellite virus…”
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SARS-CoV-2 Proteome-Wide Analysis Revealed Significant Epitope Signatures in COVID-19 Patients by Schwarz, Tatjana, Heiss, Kirsten, Mahendran, Yuvaraj, Casilag, Fiordiligie, Kurth, Florian, Sander, Leif E, Wendtner, Clemens-Martin, Hoechstetter, Manuela A, Müller, Marcel A, Sekul, Renate, Drosten, Christian, Stadler, Volker, Corman, Victor M

“…The WHO declared the COVID-19 outbreak a public health emergency of international concern. The causative agent of this acute respiratory disease is a newly…”
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Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study by Reusken, Chantal BEM, PhD, Haagmans, Bart L, PhD, Müller, Marcel A, PhD, Gutierrez, Carlos, Prof, Godeke, Gert-Jan, BSc, Meyer, Benjamin, MSc, Muth, Doreen, PhD, Raj, V Stalin, PhD, Vries, Laura Smits-De, MSc, Corman, Victor M, MD, Drexler, Jan-Felix, MD, Smits, Saskia L, PhD, El Tahir, Yasmin E, PhD, De Sousa, Rita, PhD, van Beek, Janko, MSc, Nowotny, Norbert, Prof, van Maanen, Kees, PhD, Hidalgo-Hermoso, Ezequiel, DVM, Bosch, Berend-Jan, PhD, Rottier, Peter, Prof, Osterhaus, Albert, Prof, Gortázar-Schmidt, Christian, PhD, Drosten, Christian, Prof, Koopmans, Marion PG, Prof

“…Summary Background A new betacoronavirus—Middle East respiratory syndrome coronavirus (MERS-CoV)—has been identified in patients with severe acute respiratory…”
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MERS-CoV Antibodies in Humans, Africa, 2013-2014 by Liljander, Anne, Meyer, Benjamin, Jores, Joerg, Müller, Marcel A, Lattwein, Erik, Njeru, Ian, Bett, Bernard, Drosten, Christian, Corman, Victor Max

“…Dromedaries in Africa and elsewhere carry the Middle East respiratory syndrome coronavirus (MERS-CoV). To search for evidence of autochthonous MERS-CoV…”
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