Search Results - "Müller, Kim"

Overview of Aerosol Properties in the European Arctic in Spring 2019 Based on In Situ Measurements and Lidar Data by Rader, Fieke, Traversi, Rita, Severi, Mirko, Becagli, Silvia, Müller, Kim-Janka, Nakoudi, Konstantina, Ritter, Christoph

“…In this work, we analysed aerosol measurements from lidar and PM10 samples around the European Arctic site of Ny-Ålesund during late winter–early spring 2019…”
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Aerosol Investigation During the Arctic Haze Season of 2018: Optical and Hygroscopic Properties by Müller, Kim Janka, Ritter, Christoph, Nakoudi, Konstantina

“…In the beginning of March 2018, Lidar measurements were performed on Svalbard, Arctic Ocean, in order to analyse the optical and hygroscopic properties of…”
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When β-cells fail: lessons from dedifferentiation by Accili, D., Talchai, S. C., Kim-Muller, J. Y., Cinti, F., Ishida, E., Ordelheide, A. M., Kuo, T., Fan, J., Son, J.

“…Diabetes is caused by a combination of impaired responsiveness to insulin and reduced production of insulin by the pancreas. Until recently, the decline of…”
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Stereoselective synthesis of side chain-functionalized tetrahydropyrans from 5-hexenols by Fries, Patrick, Müller, Melanie Kim, Hartung, Jens

“…Molecular oxygen stereoselectively converts 5-hexenols into 2,6-trans-, 2,5-trans-, and 2,4-cis-derivatives of 2-methyltetrahydropyran via oxidative…”
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An aerobic oxidation/homolytic substitution-cascade for stereoselective methylsulfanyl-cyclization of 4-pentenols by Fries, Patrick, Müller, Melanie Kim, Hartung, Jens

“…4-Pentenols (dihomoallylic alcohols) are oxidized by cobalt(II)-activated dioxygen in solutions of dimethyl disulfide and cyclohexa-1,4-diene to afford…”
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Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice by Kim-Muller, Ja Young, Fan, Jason, Kim, Young Jung R., Lee, Seung-Ah, Ishida, Emi, Blaner, William S., Accili, Domenico

“…Insulin-producing β cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or…”
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Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate by Christensen, Kim Müller, Pedersen, Michael Jønch, Dam-Johansen, Kim, Holm, Thomas Lønberg, Skovby, Tommy, Kiil, Søren

“…A novel filter reactor system for continuous production of selected pharmaceutical intermediates is presented and experimentally verified. The filter reactor…”
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Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice by Kim-Muller, Ja Young, Zhao, Shangang, Srivastava, Shekhar, Mugabo, Yves, Noh, Hye-Lim, Kim, YoungJung R., Madiraju, S.R. Murthy, Ferrante, Anthony W., Skolnik, Edward Y., Prentki, Marc, Accili, Domenico

“…Pancreatic β cell failure in type 2 diabetes is associated with functional abnormalities of insulin secretion and deficits of β cell mass. It’s unclear how one…”
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Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation by Qiang, Li, Lin, Hua V., Kim-Muller, Ja Young, Welch, Carrie L., Gu, Wei, Accili, Domenico

“…Dyslipidemia and atherosclerosis are associated with reduced insulin sensitivity and diabetes, but the mechanism is unclear. Gain of function of the gene…”
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GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia by Kim-Muller, Ja Young, Song, LouJin, LaCarubba Paulhus, Brianna, Pashos, Evanthia, Li, Xiangping, Rinaldi, Anthony, Joaquim, Stephanie, Stansfield, John C., Zhang, Jiangwei, Robertson, Andrew, Pang, Jincheng, Opsahl, Alan, Boucher, Magalie, Breen, Danna, Hales, Katherine, Sheikh, Abdul, Wu, Zhidan, Zhang, Bei B.

“…Cancer cachexia is a disorder characterized by involuntary weight loss and impaired physical performance. Decline in physical performance of patients with…”
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Increased Atherosclerosis and Endothelial Dysfunction in Mice Bearing Constitutively Deacetylated Alleles of Foxo1 Gene by Qiang, Li, Tsuchiya, Kyoichiro, Kim-Muller, Ja-Young, Lin, Hua V., Welch, Carrie, Accili, Domenico

“…Complications of atherosclerosis are the leading cause of death of patients with type 2 (insulin-resistant) diabetes. Understanding the mechanisms by which…”
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Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure by Fan, Jason, Du, Wen, Kim-Muller, Ja Young, Son, Jinsook, Kuo, Taiyi, Larrea, Delfina, Garcia, Christian, Kitamoto, Takumi, Kraakman, Michael J., Owusu-Ansah, Edward, Cirulli, Vincenzo, Accili, Domenico

“…Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit…”
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Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice by Banks, Alexander S., Kim-Muller, Ja Young, Mastracci, Teresa L., Kofler, Natalie M., Qiang, Li, Haeusler, Rebecca A., Jurczak, Michael J., Laznik, Dina, Heinrich, Garrett, Samuel, Varman T., Shulman, Gerald I., Papaioannou, Virginia E., Accili, Domenico

“…FoxO1 integrates multiple metabolic pathways. Nutrient levels modulate FoxO1 acetylation, but the functional consequences of this posttranslational…”
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Monitoring and Control of a Continuous Grignard Reaction for the Synthesis of an Active Pharmaceutical Ingredient Intermediate Using Inline NIR spectroscopy by Cervera-Padrell, Albert E, Nielsen, Jesper P, Jønch Pedersen, Michael, Müller Christensen, Kim, Mortensen, Asmus R, Skovby, Tommy, Dam-Johansen, Kim, Kiil, Søren, Gernaey, Krist V

“…Inline near-infrared (NIR) spectroscopy has been used to monitor a continuous synthesis of an active pharmaceutical ingredient (API) intermediate by a Grignard…”
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Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retn/beta (RELM beta) Null Mice A Model of Intestinal Immune System Dysfunction in Disease Susceptibility by Wernstedt Asterholm, Ingrid, Kim-Muller, J. Y., Rutkowski, J. M., Crewe, C., Tao, C., Scherer, P. E.

“…Resistin, and its closely related homoldgs, the resistin-like molecules (RELMs) have been implicated in metabolic dysregulation, inflammation, and cancer…”
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Low-Temperature H2-deNOx in Diesel Exhaust by Eßer, Enno, Müller, Kim, Kureti, Sven

“…For NO x removal from diesel exhaust, the selective catalytic reduction (SCR) is the most common abatement technology. However, low engine load scenarios such…”
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Selective Insulin Sensitizers by Kim-Muller, Ja Young, Accili, Domenico

“…Can the liver's insensitivity to insulin in diabetes be overcome with another hormone? Type 2 diabetes mellitus and its complications are, with cardiovascular…”
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Ultra-mini-PCNL using the urological Dyna-CT in small infants: a single-center experience by Grüne, Britta, Rassweiler-Seyfried, Marie-Claire, Müller, Kim, Nuhn, Philipp, Michel, Maurice Stephan, Younsi, Nina, Stein, Raimund, Herrmann, Jonas

“…Purpose To analyze and share our experience with ultra-mini-PCNL using the urological Dyna-CT in small infants. Methods A retrospective analysis was performed…”
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Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice by Ishida, Emi, Kim-Muller, Ja Young, Accili, Domenico

“…β-Cell failure is a hallmark of type 2 diabetes. Among several cellular biological mechanisms of cellular dysfunction, we and others have recently proposed…”
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Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes by Cinti, Francesca, Bouchi, Ryotaro, Kim-Muller, Ja Young, Ohmura, Yoshiaki, Sandoval, P. R, Masini, Matilde, Marselli, Lorella, Suleiman, Mara, Ratner, Lloyd E, Marchetti, Piero, Accili, Domenico

“…Context: Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies show that β-cells become dedifferentiated in diabetes, reverting to…”
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