Search Results - "Müller, Jürgen R."

Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies by Dubois, Sigrid P, Miljkovic, Milos D, Fleisher, Thomas A, Pittaluga, Stefania, Hsu-Albert, Jennifer, Bryant, Bonita R, Petrus, Michael N, Perera, Liyanage P, Müller, Jürgen R, Shih, Joanna H, Waldmann, Thomas A, Conlon, Kevin C

“…BackgroundFull application of cytokines as oncoimmunotherapeutics requires identification of optimal regimens. Our initial effort with intravenous bolus…”
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Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer by Zhang, Meili, Yao, Zhengsheng, Dubois, Sigrid, Ju, Wei, Müller, Jürgen R, Waldmann, Thomas A

“…IL-15 has potential as an immunotherapeutic agent for cancer treatment because it is a critical factor for the proliferation and activation of natural killer…”
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ITK and IL-15 Support Two Distinct Subsets of CD8⁺ T Cells by Dubois, Sigrid, Waldmann, Thomas A., Müller, Jürgen R.

“…CD8⁺ T cells are commonly divided into naïve $CD44^{Io}CD122^{Io}$ and "memory phenotype" $CD44^{hi}CD122^{hi}$ cells. Here we show data suggesting that these…”
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Loss of cytotoxicity and gain of cytokine production in murine tumor-activated NK cells by Müller, Jürgen R, Waldmann, Thomas A, Dubois, Sigrid

“…NK cells are able to form a functional memory suggesting that some NK cells are surviving the activation process. We hypothesized that NK cell activation…”
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Survival Adjustment of Mature Dendritic Cells by IL-15 by Dubois, Sigrid P., Waldmann, Thomas A., Müller, Jürgen R.

“…The survival of CD8+/ CD44himemory phenotype T cells depends on an IL-15 activity on nonlymphoid cells. Here, we report that IL-15 and its receptor were…”
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NK cells prevent T cell lymphoma development in T cell receptor-transgenic mice by Dubois, Sigrid, Feigenbaum, Lionel, Waldmann, Thomas A., Müller, Jürgen R.

“…•IL-15 absence increased T cell lymphoma incidence in TCR-transgenic mice.•IL-15-dependent NK cells were responsible for the rejection of T cell lymphomas.•NK…”
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Distinct Pathways Involving the FK506-Binding Proteins 12 and 12.6 Underlie IL-2- versus IL-15-Mediated Proliferation of T Cells by Dubois, Sigrid, Shou, Weinian, Haneline, Laura S., Fleischer, Sidney, Waldmann, Thomas A., Müller, Jürgen R.

“…The molecular basis for the different roles of IL-2 and IL-15 in lymphocyte function has been poorly defined. Searching for differences that underlie the…”
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Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways by Müller, Jürgen R, Siebenlist, Ulrich

“…Lymphotoxin beta receptor (LTbetaR)-induced activation of NF-kappaB in mouse embryo fibroblasts was mediated by the classical pathway and by an alternative or…”
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Interleukin-15 augments NK cell–mediated ADCC of alemtuzumab in patients with CD52+ T-cell malignancies by Miljkovic, Milos D., Dubois, Sigrid P., Müller, Jürgen R., Bryant, Bonita, Ma, Elaine, Conlon, Kevin C., Waldmann, Thomas A.

“…•Treatment with IL-15 before alemtuzumab was safe and led to decreased number and proliferative activity of T-cell leukemic cells.•IL-15 was associated with…”
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Paracrine and Transpresentation Functions of IL-15 Are Mediated by Diverse Splice Versions of IL-15Rα in Human Monocytes and Dendritic Cells by Müller, Jürgen R., Waldmann, Thomas A., Kruhlak, Michael J., Dubois, Sigrid

“…Species-specific differences of post-translational modifications suggested the existence of human IL-15Rα isoforms. We identified eight new isoforms that are…”
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Selective dependence of H2-M3-restricted CD8 responses on IL-15 by Müller, Jürgen R, Waldmann, Thomas A, Dubois, Sigrid

“…We studied whether CD8 T cell responses that are mediated by unconventional MHC class Ib molecules are IL-15 dependent in mice. CD8(+) T cell responses to…”
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Effective Cytotoxicity of Dendritic Cells against Established T Cell Lymphomas in Mice by Dubois, Sigrid, Waldmann, Thomas A., Müller, Jürgen R.

“…Abstract T cell lymphomas arise in mice that constitutively express a single TCR in the absence of NK cells. Upon TCR engagement these lymphomas are able to…”
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Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action by Dubois, Sigrid, Patel, Hiral J, Zhang, Meili, Waldmann, Thomas A, Müller, Jürgen R

“…In the induction of an immune response, IL-15Ralpha on APCs transpresents IL-15 to NK and CD8(+)/CD44(high) T cells that express the IL-2/15Rbeta and gammac…”
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Engagement of lymphoma T cell receptors causes accelerated growth and the secretion of an NK cell-inhibitory factor by Dubois, Sigrid, Waldmann, Thomas A., Müller, Jürgen R.

“…The development of T cell lymphomas in mice that constitutively express a single T cell receptor is surveilled by the action of NK cells. We investigated the…”
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A very long-acting IL-15: implications for the immunotherapy of cancer by Hangasky, John A, Chen, Wei, Dubois, Sigrid P, Daenthanasanmak, Anusara, Müller, Jürgen R, Reid, Ralph, Waldmann, Thomas A, Santi, Daniel V

“…BackgroundInterleukin-15 (IL-15) is an important cytokine necessary for proliferation and maintenance of natural killer (NK) and CD8+ T cells, and with great…”
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Deletional remodeling of c-myc-deregulating chromosomal translocations by KOVALCHUK, A. L, MÜLLER, J. R, JANZ, S

“…Evidence is presented for the existence of a novel remodeling-by-deletion mechanism that alters the fine structure of c-myc-deregulating chromosomal…”
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Migration of cells with immunoglobulin/c-myc recombinations in lymphoid tissues of mice by MULLER, J. R, JONES, G. M, JANZ, S, POTTER, M

“…Recombinations between c-myc and immunoglobulin (Ig) sequences that typically occur in pristane-induced mouse plasmacytomas were detected in secondary lymphoid…”
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Stimulation of murine B lymphocytes induces a DNA exonuclease whose activity on switch-mu DNA is specifically inhibited by other germ-line switch region RNAs by Müller, J R, Marcu, K B

“…The Ig heavy chain class switch in B lymphocytes involves a unique genetic recombination that fuses specific regions within the Ig locus and deletes…”
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Generation of switch hybrid DNA between Ig heavy chain-mu and downstream switch regions in B lymphocytes by Müller, J R, Giese, T, Henry, D L, Mushinski, J F, Marcu, K B

“…Ig heavy chain isotype switching in B lymphocytes is known to be preceded by transcription of a portion of the particular heavy chain gene segment that is…”
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Selective dependence of H2-M3-restricted CD8 responses on IL-151 by Müller, Jürgen R., Waldmann, Thomas A., Dubois, Sigrid

“…We studied whether CD8 T cell responses that are mediated by non-conventional MHC class Ib molecules are IL-15-dependent in mice. CD8 + T cell responses to…”
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