Search Results - "Müller, Iris"

Keep quiet: the HUSH complex in transcriptional silencing and disease by Müller, Iris, Helin, Kristian

“…The human silencing hub (HUSH) complex is an epigenetic repressor complex whose role has emerged as an important guardian of genome integrity. It protects the…”
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Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression by Radzisheuskaya, Aliaksandra, Shlyueva, Daria, Müller, Iris, Helin, Kristian

“…CRISPR interference (CRISPRi) represents a newly developed tool for targeted gene repression. It has great application potential for studying gene function and…”
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MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells by Müller, Iris, Moroni, Ann Sophie, Shlyueva, Daria, Sahadevan, Sudeep, Schoof, Erwin M., Radzisheuskaya, Aliaksandra, Højfeldt, Jonas W., Tatar, Tülin, Koche, Richard P., Huang, Chang, Helin, Kristian

“…Deciphering the mechanisms that control the pluripotent ground state is key for understanding embryonic development. Nonetheless, the epigenetic regulation of…”
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Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review by Nitsche, Katharina S., Müller, Iris, Malcomber, Sophie, Carmichael, Paul L., Bouwmeester, Hans

“…Organ-on-chip (OoC) technology is full of engineering and biological challenges, but it has the potential to revolutionize the Next-Generation Risk Assessment…”
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The GAD65 knock out mouse – a model for GABAergic processes in fear‐ and stress‐induced psychopathology by Müller, Iris, Çalışkan, Gürsel, Stork, Oliver

“…The γ‐amino butyric acid (GABA) synthetic enzyme glutamic acid decarboxylase (GAD)65 is critically involved in the activity‐dependent regulation of GABAergic…”
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Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression by Garland, William, Müller, Iris, Wu, Mengjun, Schmid, Manfred, Imamura, Katsutoshi, Rib, Leonor, Sandelin, Albin, Helin, Kristian, Jensen, Torben Heick

“…Transposable elements (TEs) are widespread genetic parasites known to be kept under tight transcriptional control. Here, we describe a functional connection…”
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International STakeholder NETwork (ISTNET) Workshop for creating a developmental and reproductive toxicity (DART) testing roadmap for regulatory purposes

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Methylation of H3K4 Is Required for Inheritance of Active Transcriptional States by Muramoto, Tetsuya, Müller, Iris, Thomas, Giles, Melvin, Andrew, Chubb, Jonathan R.

“…Maintenance of differentiation programs requires stability, when appropriate, of transcriptional states. However, the extent to which inheritance of active…”
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Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression by Radzisheuskaya, Aliaksandra, Shlyueva, Daria, Müller, Iris, Helin, Kristian

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Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response by Müller, Iris I, Müller, Karin A L, Schönleber, Heiko, Karathanos, Athanasios, Schneider, Martina, Jorbenadze, Rezo, Bigalke, Boris, Gawaz, Meinrad, Geisler, Tobias

“…Chronic inflammation promotes atherosclerosis in cardiovascular disease and is a major prognostic factor for patients undergoing percutaneous coronary…”
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The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity by Lin, Jianhuang, Guo, Dajiang, Liu, Heng, Zhou, Wei, Wang, Chen, Müller, Iris, Kossenkov, Andrew V, Drapkin, Ronny, Bitler, Benjamin G, Helin, Kristian, Zhang, Rugang

“…The tumor immune microenvironment is influenced by the epigenetic landscape of the tumor. Here, we have identified the SETDB1-TRIM28 complex as a critical…”
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Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins by Wang, Xinzhu, Williams, Declan, Müller, Iris, Lemieux, Mackenzie, Dukart, Ramona, Maia, Isabella B. L., Wang, Hansen, Woerman, Amanda L., Schmitt-Ulms, Gerold

“…Protein interactions of Tau are of interest in efforts to decipher pathogenesis in Alzheimer’s disease, a subset of frontotemporal dementias, and other…”
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Protective role of Gremlin‐1 in myocardial function by Müller, Iris I., Schneider, Martina, Müller, Karin A. L., Lunov, Oleg, Borst, Oliver, Simmet, Thomas, Gawaz, Meinrad

“…Background Gremlin‐1 is a cystine knot protein and is expressed in organs developing fibrosis. Transient ischaemia leads to myocardial fibrosis, a major…”
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Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence by Çaliskan, Gürsel, Müller, Iris, Semtner, Marcus, Winkelmann, Aline, Raza, Ahsan S, Hollnagel, Jan O, Rösler, Anton, Heinemann, Uwe, Stork, Oliver, Meier, Jochen C

“…Parvalbumin-positive (PV) basket cells provide perisomatic inhibition in the cortex and hippocampus and control generation of memory-related network activity…”
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Pivotal Role of Serum- and Glucocorticoid-Inducible Kinase 1 in Vascular Inflammation and Atherogenesis by Borst, Oliver, Schaub, Malte, Walker, Britta, Schmid, Evi, Münzer, Patrick, Voelkl, Jakob, Alesutan, Ioana, Rodríguez, José M, Vogel, Sebastian, Schoenberger, Tanja, Metzger, Katja, Rath, Dominik, Umbach, Anja, Kuhl, Dietmar, Müller, Iris I, Seizer, Peter, Geisler, Tobias, Gawaz, Meinrad, Lang, Florian

“…OBJECTIVE—Atherosclerosis, an inflammatory disease of arterial vessel walls, requires migration and matrix metalloproteinase (MMP)-9–dependent invasion of…”
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A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation by Massberg, Steffen, Brand, Korbinian, Grüner, Sabine, Page, Sharon, Müller, Elke, Müller, Iris, Bergmeier, Wolfgang, Richter, Thomas, Lorenz, Michael, Konrad, Ildiko, Nieswandt, Bernhard, Gawaz, Meinrad

“…The contribution of platelets to the process of atherosclerosis remains unclear. Here, we show in vivo that platelets adhere to the vascular endothelium of the…”
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Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement by Müller, Iris, Besta, Felicitas, Schulz, Christian, Massberg, Steffen, Schönig, Albert, Gawaz, Meinrad

“…Dual antiplatelet therapy with aspirin and clopidogrel decreases the rate of stent thrombosis in patients undergoing percutaneous coronary intervention (PCI)…”
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Advantages and Limitations of Direct PCR Amplification of Bacterial 16S-rDNA from Resected Heart Tissue or Swabs Followed by Direct Sequencing for Diagnosing Infective Endocarditis: A Retrospective Analysis in the Routine Clinical Setting by Hunfeld, Klaus P., Penders, John, Lohr, Benedikt, Müller, Iris, Sponsel, Janina, Maneg, Daniela, Madlener, Katharina

“…Infective endocarditis (IE) is a life-threatening disease that is associated with high morbidity and mortality. Its long-term prognosis strongly depends on a…”
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GAD65 Promoter Polymorphism rs2236418 Modulates Harm Avoidance in Women via Inhibition/Excitation Balance in the Rostral ACC by Colic, Lejla, Li, Meng, Demenescu, Liliana Ramona, Li, Shija, Müller, Iris, Richter, Anni, Behnisch, Gusalija, Seidenbecher, Constanze I, Speck, Oliver, Schott, Björn H, Stork, Oliver, Walter, Martin

“…Anxiety disorders are common and debilitating conditions with higher prevalence in women. However, factors that predispose women to anxiety phenotypes are not…”
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Cocaine and COVID-19 in ST-Elevation Myocardial Infarction by Appenzeller, Florian, Gawaz, Meinrad, Müller, Iris

“…Both COVID-19 disease and cocaine consumption have prothrombotic and hypercoagulable effects and are associated with increased risk of cardiovascular events…”
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