Search Results - "Müllbacher, Arno"

Increased Survival after Gemfibrozil Treatment of Severe Mouse Influenza by Budd, Alison, Alleva, Lisa, Alsharifi, Mohammed, Koskinen, Aulikki, Smythe, Victoria, Müllbacher, Arno, Wood, Jeff, Clark, Ian

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Cytotoxic T Cells Are the Predominant Players Providing Cross-Protective Immunity Induced by γ-Irradiated Influenza A Viruses by FURUYA, Yoichi, CHAN, Jennifer, REGNER, Matthias, LOBIGS, Mario, KOSKINEN, Aulikki, KOK, Tuckweng, MANAVIS, Jim, PENG LI, MÜLLBACHER, Arno, ALSHARIFI, Mohammed

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Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone by Sugui, Janyce A, Pardo, Julian, Chang, Yun C, Zarember, Kol A, Nardone, Glenn, Galvez, Eva M, Müllbacher, Arno, Gallin, John I, Simon, Markus M, Kwon-Chung, Kyung J

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CD8+ T Cells Mediate Recovery and Immunopathology in West Nile Virus Encephalitis by Wang, Yang, Lobigs, Mario, Lee, Eva, Müllbacher, Arno

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A pro‐survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection by Mangan, Matthew S, Melo‐Silva, Carolina R, Luu, Jennii, Bird, Catherina H, Koskinen, Aulikki, Rizzitelli, Alexandra, Prakash, Monica, Scarff, Katrina L, Müllbacher, Arno, Regner, Matthias, Bird, Phillip I

“…Intracellular serpins are proposed to inactivate proteases released from lysosome‐related organelles into the host cell interior, preventing cell death…”
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Cutting Edge: Rapid and Efficient In Vivo Cytotoxicity by Cytotoxic T Cells Is Independent of Granzymes A and B by Regner, Matthias, Pavlinovic, Lisa, Koskinen, Aulikki, Young, Nicolie, Trapani, Joseph A, Mullbacher, Arno

“…Cytotoxic T (Tc) cells lyse target cells via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell…”
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Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations by Furuya, Yoichi, Regner, Matthias, Lobigs, Mario, Koskinen, Aulikki, Müllbacher, Arno, Alsharifi, Mohammed

“…We have recently shown that intranasal (i.n.) administration of gamma-irradiated A/PR/8 [A/Puerto Rico/8/34 (H1N1)] protects mice against lethal avian…”
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mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice by Pardo, Julian, Urban, Christin, Galvez, Eva M, Ekert, Paul G, Müller, Uwe, Kwon-Chung, June, Lobigs, Mario, Müllbacher, Arno, Wallich, Reinhard, Borner, Christoph, Simon, Markus M

“…Aspergillus fumigatus infections cause high levels of morbidity and mortality in immunocompromised patients. Gliotoxin (GT), a secondary metabolite, is…”
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Apoptotic Pathways Are Selectively Activated by Granzyme A and/or Granzyme B in CTL-Mediated Target Cell Lysis by Pardo, Julián, Bosque, Alberto, Brehm, Reina, Wallich, Reinhard, Naval, Javier, Müllbacher, Arno, Anel, Alberto, Simon, Markus M.

“…Purified cytolytic T lymphocyte (CTL) proteases granzyme (gzm)A and gzmB with sublytic dose of perforin (perf) initiate distinct proapoptotic pathways. Their…”
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Ectromelia virus N1L is essential for virulence but not dissemination in a classical model of mousepox by Melo-Silva, Carolina R., Tscharke, David C., Lobigs, Mario, Koskinen, Aulikki, Müllbacher, Arno, Regner, Matthias

“…•N1 expression is critical for mousepox pathogenesis.•The lack of N1 culminates with low virus replication and protection of organs and animals from an…”
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Interferon type I responses in primary and secondary infections by Alsharifi, Mohammed, Müllbacher, Arno, Regner, Matthias

“…The mammalian host responds to a microbial infection with a rapid innate immune reaction that is dominated by type I interferon (IFN‐I) release. Most cells of…”
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The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation by Pardo, Julián, Aguilo, Juan Ignacio, Anel, Alberto, Martin, Praxedis, Joeckel, Lars, Borner, Christoph, Wallich, Reiner, Müllbacher, Arno, Froelich, Christopher J., Simon, Markus M.

“…The granule exocytosis pathway of cytotoxic lymphocytes (Tc and NK cells) is critical for control of tumor development and viral infections. Granule-associated…”
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Role of laeA in the Regulation of alb1, gliP, Conidial Morphology, and Virulence in Aspergillus fumigatus by Sugui, Janyce A, Pardo, Julian, Chang, Yun C, Müllbacher, Arno, Zarember, Kol A, Galvez, Eva M, Brinster, Lauren, Zerfas, Patricia, Gallin, John I, Simon, Markus M, Kwon-Chung, Kyung J

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Cell death induced by the Fas/Fas ligand pathway and its role in pathology by Waring, Paul, Müllbacher, Arno

“…Engagement of the cell death surface receptor Fas by Fas ligand (FasL) results in apoptotic cell death, mediated by caspase activation. Cell death mediated via…”
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Exhaustion of Type I Interferon Response following an Acute Viral Infection by Alsharifi, Mohammed, Regner, Matthias, Blanden, Robert, Lobigs, Mario, Lee, Eva, Koskinen, Aulikki, Mullbacher, Arno

“…Viral infections often cause a period of heightened susceptibility to a secondary infection but the cause of this phenomenon is unknown. We found that a…”
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Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections by Alsharifi, Mohammed, Furuya, Yoichi, Bowden, Timothy R, Lobigs, Mario, Koskinen, Aulikki, Regner, Matthias, Trinidad, Lee, Boyle, David B, Müllbacher, Arno

“…Influenza A (flu) virus causes significant morbidity and mortality worldwide, and current vaccines require annual updating to protect against the rapidly…”
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Lack of both Fas Ligand and Perforin Protects from Flavivirus-Mediated Encephalitis in Mice by Licon Luna, Rosa M, Lee, Eva, Müllbacher, Arno, Blanden, Robert V, Langman, Rod, Lobigs, Mario

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Type I Interferons Trigger Systemic, Partial Lymphocyte Activation in Response to Viral Infection by Alsharifi, Mohammed, Lobigs, Mario, Regner, Matthias, Lee, Eva, Koskinen, Aulikki, Mullbacher, Arno

“…The vast majority of both T and B cells in mice were found to up-regulate cell surface expression of the early activation markers CD69 and CD86, but not CD25,…”
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In vivo elimination of MHC-I-deficient lymphocytes by activated natural killer cells is independent of granzymes A and B by Regner, Matthias, Pavlinovic, Lisa, Young, Nicolie, Müllbacher, Arno

“…NK cells kill target cells mainly via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell…”
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Granzymes are the Essential Downstream Effector Molecules for the Control of Primary Virus Infections by Cytolytic Leukocytes by Müllbacher, Arno, Waring, Paul, Hla, Ron Tha, Tran, Thao, Chin, Seow, Stehle, Thomas, Museteanu, Crisan, Simon, Markus M.

“…Analysis of perforin-deficient mice has identified the cytolytic pathway and perforin as the preeminent effector molecule in T cell-mediated control of virus…”
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