Search Results - "Møller, Lennart"

Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer size by Karlsson, Hanna L., Gustafsson, Johanna, Cronholm, Pontus, Möller, Lennart

“…Toxicological studies have shown increased toxicity of nanoparticles (<100 nm) compared to micrometer particles of the same composition, which has raised…”
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Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes by Karlsson, Hanna L, Cronholm, Pontus, Gustafsson, Johanna, Möller, Lennart

“…Since the manufacture and use of nanoparticles are increasing, humans are more likely to be exposed occupationally or via consumer products and the…”
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Time trends in survival and causes of death in multiple myeloma: a population-based study from Germany by Eisfeld, Christine, Kajüter, Hiltraud, Möller, Lennart, Wellmann, Ina, Shumilov, Evgenii, Stang, Andreas

“…Steady evolution of therapies has improved prognosis of patients with multiple myeloma (MM) over the past two decades. Yet, knowledge about survival trends and…”
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Nickel Release, ROS Generation and Toxicity of Ni and NiO Micro- and Nanoparticles by Latvala, Siiri, Hedberg, Jonas, Di Bucchianico, Sebastiano, Möller, Lennart, Odnevall Wallinder, Inger, Elihn, Karine, Karlsson, Hanna L

“…Occupational exposure to airborne nickel is associated with an elevated risk for respiratory tract diseases including lung cancer. Therefore, the increased…”
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Surface Characteristics, Copper Release, and Toxicity of Nano- and Micrometer-Sized Copper and Copper(II) Oxide Particles: A Cross-Disciplinary Study by Midander, Klara, Cronholm, Pontus, Karlsson, Hanna L., Elihn, Karine, Möller, Lennart, Leygraf, Christofer, Wallinder, Inger Odnevall

“…An interdisciplinary and multianalytical research effort is undertaken to assess the toxic aspects of thoroughly characterized nano‐ and micrometer‐sized…”
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Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells? by Collins, Andrew R, Cadet, Jean, Mőller, Lennart, Poulsen, Henrik E, Viña, Jose

“…The most commonly measured marker of oxidative DNA damage is 8-oxo-7,8-dihydroguanine (8-oxoGua) or its deoxyribonucleoside (8-oxodGuo). Published estimates of…”
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The effects on DNA migration of altering parameters in the comet assay protocol such as agarose density, electrophoresis conditions and durations of the enzyme or the alkaline treatments by Ersson, Clara, Möller, Lennart

“…The single cell gel electrophoresis (comet assay) is a popular method for measuring DNA migration as an estimate of DNA damage. No standardised comet assay…”
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Copper-based nanoparticles induce high toxicity in leukemic HL60 cells by Rodhe, Ylva, Skoglund, Sara, Odnevall Wallinder, Inger, Potácová, Zuzana, Möller, Lennart

“…•High cytotoxicity of copper-based nanoparticles in HL60 cells.•Cu NPs were the most cytotoxic particles followed by CuCl2 and CuO NPs.•Cu NPs were less stable…”
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Mortality from prostate cancer in the years 2007-2021 in North Rhine-Westphalia, Germany by Claaßen, Kevin, Karpinski, Madeleine, Kajüter, Hiltraud, Hüsing, Johannes, Möller, Lennart, Wellmann, Ina, Grünwald, Viktor, Hadaschik, Boris, Albers, Peter, Stang, Andreas

“…The crude mortality rate and the lifetime mortality risk from prostate cancer in Germany are above international average. However age-standardised mortality…”
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Optimization of an air-liquid interface exposure system for assessing toxicity of airborne nanoparticles by Latvala, Siiri, Hedberg, Jonas, Möller, Lennart, Odnevall Wallinder, Inger, Karlsson, Hanna L., Elihn, Karine

“…The use of refined toxicological methods is currently needed for characterizing the risks of airborne nanoparticles (NPs) to human health. To mimic pulmonary…”
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Subway Particles Are More Genotoxic than Street Particles and Induce Oxidative Stress in Cultured Human Lung Cells by Karlsson, Hanna L, Nilsson, Lennart, Möller, Lennart

“…Epidemiological studies have shown an association between airborne particles and a wide range of adverse health effects. The mechanisms behind these effects…”
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Bioaccessibility, bioavailability and toxicity of commercially relevant iron- and chromium-based particles: in vitro studies with an inhalation perspective by Hedberg, Yolanda, Gustafsson, Johanna, Karlsson, Hanna L, Möller, Lennart, Odnevall Wallinder, Inger

“…Production of ferrochromium alloys (FeCr), master alloys for stainless steel manufacture, involves casting and crushing processes where particles inevitably…”
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Mechanisms Related to the Genotoxicity of Particles in the Subway and from Other Sources by Karlsson, Hanna L, Holgersson, Åsa, Möller, Lennart

“…Negative health effects of airborne particles have clearly been shown in epidemiological studies. People get exposed to particles from various sources such as…”
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Comparison of genotoxic and inflammatory effects of particles generated by wood combustion, a road simulator and collected from street and subway by Karlsson, Hanna L., Ljungman, Anders G., Lindbom, John, Möller, Lennart

“…The health effects of exposure to airborne particles are of increasing concern in society. In order to protect public health, a clarification of the toxic…”
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Variation in the measurement of DNA damage by comet assay measured by the ECVAG† inter-laboratory validation trial by Forchhammer, Lykke, Johansson, Clara, Loft, Steffen, Möller, Lennart, Godschalk, Roger W. L., Langie, Sabine A. S., Jones, George D. D., Kwok, Rachel W. L., Collins, Andrew R., Azqueta, Amaya, Phillips, David H., Sozeri, Osman, Stępnik, Maciej, Palus, Jadwiga, Vogel, Ulla, Wallin, Håkan, Routledge, Michael N., Handforth, Catherine, Allione, Alessandra, Matullo, Giuseppe, Teixeira, João Paulo, Costa, Solange, Riso, Patrizia, Porrini, Marisa, Møller, Peter

“…The comet assay has become a popular method for the assessment of DNA damage in biomonitoring studies and genetic toxicology. However, few studies have…”
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Assessment and reduction of comet assay variation in relation to DNA damage: studies from the European Comet Assay Validation Group by Møller, Peter, Möller, Lennart, Godschalk, Roger W. L., Jones, George D. D.

“…The alkaline single cell gel electrophoresis (comet) assay has become a widely used method for the detection of DNA damage and repair in cells and tissues…”
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DNA adduct and tumor formations in rats after intratracheal administration of the urban air pollutant 3-nitrobenzanthrone by Nagy, Eszter, Zeisig, Magnus, Kawamura, Ken, Hisamatsu, Yoshiharu, Sugeta, Akiko, Adachi, Shuichi, Möller, Lennart

“…3-Nitrobenzanthrone (3-NBA) has been isolated from diesel exhaust and airborne particles and identified as a potent direct-acting mutagen in vitro and…”
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An ECVAG trial on assessment of oxidative damage to DNA measured by the comet assay by Johansson, Clara, Møller, Peter, Forchhammer, Lykke, Loft, Steffen, Godschalk, Roger W. L., Langie, Sabine A. S., Lumeij, Stijn, Jones, George D. D., Kwok, Rachel W. L., Azqueta, Amaya, Phillips, David H., Sozeri, Osman, Routledge, Michael N., Charlton, Alexander J., Riso, Patrizia, Porrini, Marisa, Allione, Alessandra, Matullo, Giuseppe, Palus, Jadwiga, Stepnik, Maciej, Collins, Andrew R., Möller, Lennart

“…The increasing use of single cell gel electrophoresis (the comet assay) highlights its popularity as a method for detecting DNA damage, including the use of…”
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DNA oxidative damage and strand breaks in young healthy individuals: a gender difference and the role of life style factors by Hofer, Tim, Karlsson, Hanna L, Möller, Lennart

“…The aim of this study was to analyze background levels of DNA damage in young (19-31 years) non-smoking individuals and to correlate damage to gender and life…”
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The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non–small cell lung carcinoma cells to DNA double-strand break–induced cell death by Polischouk, Anya G, Holgersson, Asa, Zong, Dali, Stenerlöw, Bo, Karlsson, Hanna L, Möller, Lennart, Viktorsson, Kristina, Lewensohn, Rolf

“…Trifluoperazine (TFP), a member of the phenothiazine class of antipsychotic drugs, has been shown to augment the cytotoxicity of the DNA-damaging agent…”
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