Search Results - "Mönkkönen, Jukka"

ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity Using In Vitro Cell Culture Model by Mulik, Rohit S, Mönkkönen, Jukka, Juvonen, Risto O, Mahadik, Kakasaheb R, Paradkar, Anant R

“…Beta amyloid plays a main role in the pathophysiology of Alzheimer’s disease by inducing oxidative stress in the brain. Curcumin, a natural antioxidant, is…”
Get full text

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories by Hayeshi, Rose, Hilgendorf, Constanze, Artursson, Per, Augustijns, Patrick, Brodin, Birger, Dehertogh, Pascale, Fisher, Karen, Fossati, Lina, Hovenkamp, Egbert, Korjamo, Timo, Masungi, Chantal, Maubon, Nathalie, Mols, Raf, Müllertz, Anette, Mönkkönen, Jukka, O’Driscoll, Caitriona, Oppers-Tiemissen, H.M., Ragnarsson, Eva G.E., Rooseboom, Martijn, Ungell, Anna-Lena

“…Caco-2 cells, widely used to study carrier mediated uptake and efflux mechanisms, are known to have different properties when cultured under different…”
Get full text

Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits by DANENBERG, Haim D, FISHBEIN, Ilia, JIANCHUAN GAO, MÖNKKÖNEN, Jukka, REICH, Reuven, GATI, Irith, MOERMAN, Evgeny, GOLOMB, Gershon

“…Inflammation is critical to vascular repair after mechanical injury. Excessive inflammation enhances neointimal formation and restenosis. We examined whether…”
Get full text

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen‐containing bisphosphonates by Mönkkönen, Hannu, Auriola, Seppo, Lehenkari, Petri, Kellinsalmi, Maarit, Hassinen, Ilmo E, Vepsäläinen, Jouko, Mönkkönen, Jukka

“…Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess bone resorption. On the basis of…”
Get full text

Rebuilding East and North by Jukka Mönkkönen

Get full text

Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton by Rogers, Michael J., Mönkkönen, Jukka, Munoz, Marcia A.

“…Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption in skeletal disorders such as osteoporosis and metastatic bone…”
Get full text

Human breast cancer cells educate macrophages toward the M2 activation status by Sousa, Sofia, Brion, Régis, Lintunen, Minnamaija, Kronqvist, Pauliina, Sandholm, Jouko, Mönkkönen, Jukka, Kellokumpu-Lehtinen, Pirkko-Liisa, Lauttia, Susanna, Tynninen, Olli, Joensuu, Heikki, Heymann, Dominique, Määttä, Jorma A

“…The immune system plays a major role in cancer progression. In solid tumors, 5-40 % of the tumor mass consists of tumor-associated macrophages (TAMs) and there…”
Get full text

Decrease in Intracellular Concentration Causes the Shift in Km Value of Efflux Pump Substrates by Korjamo, Timo, Kemiläinen, Heidi, Heikkinen, Aki T, Mönkkönen, Jukka

“…Passive permeability and active efflux are parallel processes in transcellular flux. Therefore, the observed kinetics of a transporter substrate depends on…”
Get full text

Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs by Benford, H L, Frith, J C, Auriola, S, Mönkkönen, J, Rogers, M J

“…Recently, advances have been made in understanding the molecular mechanisms by which bisphosphonate drugs inhibit bone resorption. Studies with the…”
Get more information

Clodronate and Liposome‐Encapsulated Clodronate Are Metabolized to a Toxic ATP Analog, Adenosine 5′‐(β,γ‐Dichloromethylene) Triphosphate, by Mammalian Cells In Vitro by Frith, Julie C., Mönkkönen, Jukka, Blackburn, G. Michael, Russell, R. Graham G., Rogers, Michael J.

“…Clodronate, alendronate, and other bisphosphonates are widely used in the treatment of bone diseases characterized by excessive osteoclastic bone resorption…”
Get full text

Biochemical and molecular mechanisms of action of bisphosphonates by Rogers, Michael J, Crockett, Julie C, Coxon, Fraser P, Mönkkönen, Jukka

“…Abstract This review describes the key discoveries over the last 15 years that have led to a clearer understanding of the molecular mechanisms by which…”
Get full text

Rapid Screening Method for Osteoclast Differentiation in Vitro That Measures Tartrate-resistant Acid Phosphatase 5b Activity Secreted into the Culture Medium by Alatalo, Sari L, Halleen, Jussi M, Hentunen, Teuvo A, Monkkonen, Jukka, Vaananen, H. Kalervo

“…Osteoclasts secrete tartrate-resistant acid phosphatase (TRAP; EC 3.1.3.2) 5b into the circulation. We studied the release of TRAP 5b from osteoclasts using a…”
Get full text

Analysis of unstirred water layer in in vitro permeability experiments by Korjamo, Timo, Heikkinen, Aki T, Mönkkönen, Jukka

“…In vitro permeability experiments are used widely in drug discovery and other areas of pharmaceutical research. Much effort has been expended in developing…”
Get more information

In vitro Comparison of Clodronate, Pamidronate and Zoledronic Acid Effects on Rat Osteoclasts and Human Stem Cell‐Derived Osteoblasts by Kellinsalmi, Maarit, Mönkkönen, Hannu, Mönkkönen, Jukka, Leskelä, Hannu‐Ville, Parikka, Vilhelmiina, Hämäläinen, Martti, Lehenkari, Petri

“…: In the present study we compared the first generation non‐nitrogen‐containing bisphosphonate, clodronate with second and third generation nitrogen‐containing…”
Get full text

Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells by Wang, Hong, Henry, Olivier, Distefano, Mark D, Wang, Yen-Chih, Räikkönen, Johanna, Mönkkönen, Jukka, Tanaka, Yoshimasa, Morita, Craig T

“…Most human γδ T cells express Vγ2Vδ2 TCRs and play important roles in microbial and tumor immunity. Vγ2Vδ2 T cells are stimulated by self- and foreign prenyl…”
Get full text

Liposome-encapsulated zoledronate increases inflammatory macrophage population in TNBC tumours by Petruk, Nataliia, Sousa, Sofia, Croset, Martine, Polari, Lauri, Zlatev, Hristo, Selander, Katri, Mönkkönen, Jukka, Clézardin, Philippe, Määttä, Jorma

“…Tumour associated macrophages (TAMs) are important players in breast tumour progression and metastasis. Clinical and preclinical evidence suggests a role for…”
Get full text

Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis by Mulik, Rohit S., Mönkkönen, Jukka, Juvonen, Risto O., Mahadik, Kakasaheb R., Paradkar, Anant R.

“…Photodegradation and low bioavailability are major hurdles for the therapeutic use of curcumin. Aim of the present study was to formulate transferrin-mediated…”
Get full text

Effects of various absorption enhancers on transport of clodronate through Caco-2 cells by Raiman, Johanna, Törmälehto, Soili, Yritys, Kirsi, Junginger, Hans E, Mönkkönen, Jukka

“…The major disadvantage concerning clinical use of bishosphonate drugs, like clodronate, is their poor and variable absorption after oral administration. The…”
Get full text

Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells by Sousa, Sofia, Auriola, Seppo, Mönkkönen, Jukka, Määttä, Jorma

“…Tumour stromal macrophages differentiate to tumour-associated macrophages (TAMs) with characteristics of immunosuppressive M2-type macrophages, having a…”
Get full text

Nitrogen-containing bisphosphonates and alkylamines activate Vγ9Vδ2 T cells through a common mechanism involving inhibition of the mevalonate pathway by Thompson, Keith, Mönkkönen ⁎, Hannu, Mönkkönen ⁎, Jukka, Rogers, MichaelJ

Get full text