Search Results - "Möller, Christer"

Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer’s Disease by Söderberg, Linda, Johannesson, Malin, Nygren, Patrik, Laudon, Hanna, Eriksson, Fredrik, Osswald, Gunilla, Möller, Christer, Lannfelt, Lars

“…Immunotherapy against amyloid-beta (Aβ) is a promising option for the treatment of Alzheimer’s disease (AD). Aβ exists as various species, including monomers,…”
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The murine version of BAN2401 (mAb158) selectively reduces amyloid-β protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice by Tucker, Stina, Möller, Christer, Tegerstedt, Karin, Lord, Anna, Laudon, Hanna, Sjödahl, Johan, Söderberg, Linda, Spens, Erika, Sahlin, Charlotte, Waara, Erik Rollman, Satlin, Andrew, Gellerfors, Pär, Osswald, Gunilla, Lannfelt, Lars

“…Amyloid-β (Aβ) immunotherapy for Alzheimer's disease (AD) has good preclinical support from transgenic mouse models and clinical data suggesting that a…”
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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease by Nordström, Eva, Eriksson, Fredrik, Sigvardson, Jessica, Johannesson, Malin, Kasrayan, Alex, Jones-Kostalla, Martina, Appelkvist, Paulina, Söderberg, Linda, Nygren, Patrik, Blom, Magdalena, Rachalski, Adeline, Nordenankar, Karin, Zachrisson, Olof, Amandius, Ebba, Osswald, Gunilla, Moge, Mikael, Ingelsson, Martin, Bergström, Joakim, Lannfelt, Lars, Möller, Christer, Giorgetti, Marco, Fälting, Johanna

“…A growing body of evidence suggests that aggregated α-synuclein, the major constituent of Lewy bodies, plays a key role in the pathogenesis of Parkinson's…”
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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities by Söderberg, Linda, Johannesson, Malin, Gkanatsiou, Eleni, Nygren, Patrik, Fritz, Nicolas, Zachrisson, Olof, Rachalski, Adeline, Svensson, Anne-Sophie, Button, Emily, Dentoni, Giacomo, Osswald, Gunilla, Lannfelt, Lars, Möller, Christer

“…Therapeutic antibodies have been developed to target amyloid-beta (Aβ), and some of these slow the progression of Alzheimer’s disease (AD). However, they can…”
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Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice by Lindström, Veronica, Fagerqvist, Therese, Nordström, Eva, Eriksson, Fredrik, Lord, Anna, Tucker, Stina, Andersson, Jessica, Johannesson, Malin, Schell, Heinrich, Kahle, Philipp J, Möller, Christer, Gellerfors, Pär, Bergström, Joakim, Lannfelt, Lars, Ingelsson, Martin

“…Abstract Several lines of evidence suggest that accumulation of aggregated alpha-synuclein (α-synuclein) in the central nervous system (CNS) is an early…”
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Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains by Johannesson, Malin, Söderberg, Linda, Zachrisson, Olof, Fritz, Nicolas, Kylefjord, Helen, Gkanatsiou, Eleni, Button, Emily, Svensson, Anne-Sophie, Rachalski, Adeline, Nygren, Patrik, Osswald, Gunilla, Lannfelt, Lars, Möller, Christer

“…Recent advances in immunotherapeutic approaches to the treatment of Alzheimer's disease (AD) have increased the importance of understanding the exact binding…”
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Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease by Lannfelt, Lars, Möller, Christer, Basun, Hans, Osswald, Gunilla, Sehlin, Dag, Satlin, Andrew, Logovinsky, Veronika, Gellerfors, Pär

“…The symptomatic drugs currently on the market for Alzheimer's disease (AD) have no effect on disease progression, and this creates a large unmet medical need…”
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Characterization of monomeric and soluble aggregated Aβ in Down’s syndrome and Alzheimer’s disease brains by Gkanatsiou, Eleni, Sahlin, Charlotte, Portelius, Erik, Johannesson, Malin, Söderberg, Linda, Fälting, Johanna, Basun, Hans, Möller, Christer, Odergren, Tomas, Zetterberg, Henrik, Blennow, Kaj, Lannfelt, Lars, Brinkmalm, Gunnar

“…•The Aβ peptide pattern is generally similar in AD and DS, except the BACE1 site-spanning APP/Aβ peptides.•N-truncated AβX-34, AβX-40, and AβX-42 peptides are…”
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Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice by Rizoska, Biljana, Zachrisson, Olof, Appelkvist, Paulina, Boström, Emma, Björklund, My, Rachalski, Adeline, Gkanatsiou, Eleni, Kylefjord, Helen, Söderberg, Linda, Nygren, Patrik, Eriksson, Fredrik, Ishikawa, Yukio, Fukushima, Tatsuto, Koyama, Akihiko, Osswald, Gunilla, Lannfelt, Lars, Möller, Christer

“…Amyloid beta (Aβ) peptides, which aggregate to form neocortical plaques in Alzheimer's disease, exist in states that range from soluble monomers and…”
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Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease by Johannesson, Malin, Sahlin, Charlotte, Söderberg, Linda, Basun, Hans, Fälting, Johanna, Möller, Christer, Zachrisson, Olof, Sunnemark, Dan, Svensson, Anne, Odergren, Tomas, Lannfelt, Lars

“…Down syndrome (DS) is caused by trisomy of chromosome 21, which leads to a propensity to develop amyloid β (Aβ) brain pathology in early adulthood followed…”
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Rapid amyloid‐β oligomer and protofibril accumulation in traumatic brain injury by Abu Hamdeh, Sami, Waara, Erik Rollman, Möller, Christer, Söderberg, Linda, Basun, Hans, Alafuzoff, Irina, Hillered, Lars, Lannfelt, Lars, Ingelsson, Martin, Marklund, Niklas

“…Deposition of amyloid‐β (Aβ) is central to Alzheimer's disease (AD) pathogenesis and associated with progressive neurodegeneration in traumatic brain injury…”
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The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy by Johansson, Björn, Oasa, Sho, Muntsant Soria, Aida, Tiiman, Ann, Söderberg, Linda, Amandius, Ebba, Möller, Christer, Lannfelt, Lars, Terenius, Lars, Giménez-Llort, Lydia, Vukojević, Vladana

“…Standard neuropathologic analysis of Alzheimer's brain relies on traditional fluorescence microscopy, which suffers from limited spatial resolution due to…”
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An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease by Lord, Anna, Gumucio, Astrid, Englund, Hillevi, Sehlin, Dag, Sundquist, Valentina Screpanti, Söderberg, Linda, Möller, Christer, Gellerfors, Pär, Lannfelt, Lars, Pettersson, Frida Ekholm, Nilsson, Lars N.G

“…Abstract Human genetics link Alzheimer's disease pathogenesis to excessive accumulation of amyloid-β (Aβ) in brain, but the symptoms do not correlate with…”
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Monoclonal antibodies selective for α‐synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α‐synuclein transgenic mice with the disease‐causing A30P mutation by Fagerqvist, Therese, Lindström, Veronica, Nordström, Eva, Lord, Anna, Tucker, Stina M. E., Su, Xingjian, Sahlin, Charlotte, Kasrayan, Alex, Andersson, Jessica, Welander, Hedvig, Näsström, Thomas, Holmquist, Mats, Schell, Heinrich, Kahle, Philipp J., Kalimo, Hannu, Möller, Christer, Gellerfors, Pär, Lannfelt, Lars, Bergström, Joakim, Ingelsson, Martin

“…Inclusions of intraneuronal alpha‐synuclein (α‐synuclein) can be detected in brains of patients with Parkinson's disease and dementia with Lewy bodies. The…”
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Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors by Gustafsson, Gabriel, Eriksson, Fredrik, Möller, Christer, da Fonseca, Tomás Lopes, Outeiro, Tiago F., Lannfelt, Lars, Bergström, Joakim, Ingelsson, Martin

“…Immunotherapy targeting aggregated α-synuclein has emerged as a potential treatment strategy against Parkinson’s disease and other α-synucleinopathies. We have…”
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Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders by Lindström, Veronica, Ihse, Elisabet, Fagerqvist, Therese, Bergström, Joakim, Nordström, Eva, Möller, Christer, Lannfelt, Lars, Ingelsson, Martin

“…Immunotherapy targeting α-synuclein has evolved as a potential therapeutic strategy for neurodegenerative diseases, such as Parkinson's disease, and initial…”
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Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy by Matzner, Ulrich, Herbst, Eva, Hedayati, Kerstin Khalaj, Lüllmann-Rauch, Renate, Wessig, Carsten, Schröder, Stephan, Eistrup, Carl, Möller, Christer, Fogh, Jens, Gieselmann, Volkmar

“…A deficiency of arylsulfatase A (ASA) causes the lysosomal storage disease metachromatic leukodystrophy, which is characterized by accumulation of the…”
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Variations in Porphobilinogen and 5-Aminolevulinic Acid Concentrations in Plasma and Urine from Asymptomatic Carriers of the Acute Intermittent Porphyria Gene with Increased Porphyrin Precursor Excretion by Floderus, Ylva, Sardh, Eliane, Moller, Christer, Andersson, Claes, Rejkjaer, Lillan, Andersson, Dan E.H, Harper, Pauline

“…The heme precursors porphobilinogen (PBG) and 5-aminolevulinic acid (ALA) accumulate during overt crises of acute intermittent porphyria (AIP), and high…”
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Long Term Effects of Aminoguanidine on Insulin Release and Biosynthesis: Evidence That the Formation of Advanced Glycosylation End Products Inhibits B Cell Function by Tajiri, Yuji, Christer Möller, Grill, Valdemar

“…Chronic hyperglycemia has adverse effects on B cell function. We investigated the possible role of advanced glycosylation end products (AGEs) in glucotoxicity…”
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Adenoviral-mediated Expression of Porphobilinogen Deaminase in Liver Restores the Metabolic Defect in a Mouse Model of Acute Intermittent Porphyria by Johansson, Annika, Nowak, Grzegorz, Möller, Christer, Blomberg, Pontus, Harper, Pauline

“…The aim of this study was to investigate the potential of gene therapy in the treatment of acute intermittent porphyria (AIP), a disorder caused by a partial…”
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