Search Results - "Mónica, Fabíola Zakia"
-
1
Methylglyoxal and Advanced Glycation End Products (AGEs): Targets for the Prevention and Treatment of Diabetes-Associated Bladder Dysfunction?
Published in Biomedicines (01-05-2024)“…Methylglyoxal (MGO) is a highly reactive α-dicarbonyl compound formed endogenously from 3-carbon glycolytic intermediates. Methylglyoxal accumulated in plasma…”
Get full text
Journal Article -
2
Hydrochlorothiazide Potentiates Contractile Activity of Mouse Cavernosal Smooth Muscle
Published in Sexual medicine (01-06-2016)“…Hydrochlorothiazide has a negative influence on penile erection but little is known about the mechanism(s) involved. To characterize the effects of this…”
Get full text
Journal Article -
3
Soluble Guanylate Cyclase β1 Subunit Represses Human Glioblastoma Growth
Published in Cancers (02-03-2023)“…Malignant glioma is the most common and deadly brain tumor. A marked reduction in the levels of sGC (soluble guanylyl cyclase) transcript in the human glioma…”
Get full text
Journal Article -
4
The Role of Periprostatic Adipose Tissue on Prostate Function in Vascular-Related Disorders
Published in Frontiers in pharmacology (12-02-2021)“…The lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are highly prevalent worldwide. Clinical and experimental data suggest…”
Get full text
Journal Article -
5
Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine
Published in Frontiers in pharmacology (10-07-2023)“…The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators that interfere in prostate function. In this study, we…”
Get full text
Journal Article -
6
Inhibition of multidrug resistance proteins by MK571 restored the erectile function in obese mice through cGMP accumulation
Published in Andrology (Oxford) (01-03-2023)“…Background Intracellular levels of cyclic nucleotides can also be controlled by the action of multidrug resistance protein types 4 (MRP4) and 5 (MRP5). To…”
Get full text
Journal Article -
7
Increased Rho-kinase-mediated prostate contractions associated with impairment of β-adrenergic-cAMP-signaling pathway by chronic nitric oxide deficiency
Published in European journal of pharmacology (05-07-2015)“…Impairment of nitric oxide (NO) – cyclic GMP signaling pathway is likely to contribute to human begnin prostate hyperplasia (BPH). In the present study we have…”
Get full text
Journal Article -
8
Guanosine, a guanine-based nucleoside relaxed isolated corpus cavernosum from mice through cGMP accumulation
Published in Purinergic signalling (01-06-2020)“…In corpus cavernosum (CC), guanosine triphosphate (GTP) is converted into cyclic guanosine monophosphate (cGMP) to induce erection. The action of cGMP is…”
Get full text
Journal Article -
9
Urinary Bladder Dysfunction in Transgenic Sickle Cell Disease Mice
Published in PloS one (04-08-2015)“…Urological complications associated with sickle cell disease (SCD), include nocturia, enuresis, urinary infections and urinary incontinence. However,…”
Get full text
Journal Article -
10
BAY 41-2272, a Soluble Guanylate Cyclase Stimulator, Relaxes Isolated Human Ureter in a Standardized In Vitro Model
Published in Urology (Ridgewood, N.J.) (2014)“…Objective To characterize the relaxation induced by BAY 41-2272 in human ureteral segments. Materials and Methods Ureter specimens (n = 17) from multiple organ…”
Get full text
Journal Article -
11
Administration of BAY 41-2272 prevents bladder dysfunction in nitric-oxide deficient rats
Published in Einstein (São Paulo, Brazil) (01-12-2010)“…to evaluate the protective effects of BAY 41-2272, a soluble guanylate cyclase activator, on changes in cystometric parameters in rats deficient in nitric…”
Get full text
Journal Article -
12
Increased contractility and impaired relaxation of the left pulmonary artery in a rabbit model of congenital diaphragmatic hernia
Published in Pediatric surgery international (01-05-2013)“…Purpose Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypertension which is often difficult to manage and a significant cause of morbidity…”
Get full text
Journal Article -
13
Effects of nitric oxide inhibitors in mice with bladder outlet obstruction
Published in International Brazilian Journal of Urology (01-03-2017)“…To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or…”
Get full text
Journal Article -
14
The cholinergic response is increased in isolated ileum from gastroschisis rat model
Published in Pediatric surgery international (01-09-2011)“…Introduction Babies with gastroschisis (G) have high morbidity rate and long hospital stay due to bowel hypomotility caused by chronic exposure of the bowel to…”
Get full text
Journal Article -
15
Epigenetic regulation of soluble guanylate cyclase (sGC) β1 in breast cancer cells
Published in The FASEB journal (01-09-2016)“…ABSTRACT Soluble guanylate cyclase (sGC) is a heterodimer composed of a and b subunits. The loss of sGCβ1 has been implicated in several vascular and…”
Get full text
Journal Article -
16
Tadalafil for the treatment of benign prostatic hyperplasia
Published in Expert opinion on pharmacotherapy (24-05-2019)“…In men, lower urinary tract symptoms (LUTS) are primarily attributed to benign prostatic hyperplasia (BPH). Therapeutic options are targeted to relax prostate…”
Get more information
Journal Article -
17
Endothelial and vascular smooth muscle dysfunction in hypertension
Published in Biochemical pharmacology (01-11-2022)“…[Display omitted] The development of essential hypertension involves several factors. Vascular dysfunction, characterized by endothelial dysfunction, low-grade…”
Get full text
Journal Article -
18
Agomelatine inhibits platelet aggregation through melatonin receptor-dependent and independent mechanisms
Published in Life sciences (1973) (01-09-2023)“…Melatonin is known to inhibit platelet aggregation induced by arachidonic acid (AA). In the present study we investigated whether agomelatine (Ago), an…”
Get full text
Journal Article -
19
The sodium-glucose cotransporter-2 (SGLT2) inhibitors synergize with nitric oxide and prostacyclin to reduce human platelet activation
Published in Biochemical pharmacology (01-12-2020)“…[Display omitted] Gliflozins (canagliflozin, dapagliflozin and empagliflozin) are the newest anti-hyperglycemic class and have offered cardiovascular and renal…”
Get full text
Journal Article -
20
Release of 6-nitrodopamine from human popliteal artery and vein
Published in Life sciences (1973) (01-08-2023)“…6-Nitrodopamine (6-ND) is a novel catecholamine that is released from human umbilical cord vessels, and it causes vascular relaxation by acting as a dopamine…”
Get full text
Journal Article