Search Results - "Mónica, Fabíola Z."
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Tetrodotoxin-insensitive electrical field stimulation-induced contractions on Crotalus durissus terrificus corpus cavernosum
Published in PloS one (24-08-2017)“…Reptiles are the first amniotes to develop an intromitent penis, however until now the mechanisms involved in the electrical field stimulation-induced…”
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2
Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway
Published in PloS one (08-11-2012)“…Nitric oxide-independent soluble guanylyl cyclase (sGC) activators reactivate the haem-oxidized enzyme in vascular diseases. This study was undertaken to…”
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3
Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice
Published in PloS one (07-11-2012)“…Obesity/metabolic syndrome are common risk factors for overactive bladder. This study aimed to investigate the functional and molecular changes of detrusor…”
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4
Blockade of renin-angiotensin system prevents micturition dysfunction in renovascular hypertensive rats
Published in European journal of pharmacology (05-09-2014)“…Association between hypertension and bladder symptoms has been described. We hypothesized that micturition dysfunction may be associated with renin-angiotensin…”
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5
The Evolutionary Implications of Hemipenial Morphology of Rattlesnake Crotalus durissus terrificus (Laurent, 1768) (Serpentes: Viperidae: Crotalinae)
Published in PloS one (26-06-2013)“…Most amniotes vertebrates have an intromittent organ to deliver semen. The reptile Sphenodon and most birds lost the ancestral penis and developed a…”
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Stimulators and activators of soluble guanylate cyclase for urogenital disorders
Published in Nature reviews. Urology (01-01-2018)“…Key Points The nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic GMP (cGMP) signalling pathway is present in the smooth muscle of the lower urinary…”
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7
Pharmacological characterisation of the relaxation induced by the soluble guanylate cyclase activator, BAY 60‐2770 in rabbit corpus cavernosum
Published in BJU international (01-10-2015)“…Objective To characterise the relaxation induced by the soluble guanylate cyclase (sGC) activator, BAY 60‐2770 (4‐({(4‐carboxybutyl) [2‐…”
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8
Electrical field stimulation induces endothelium-dependent contraction of human umbilical cord vessels
Published in Life sciences (1973) (15-02-2020)“…Electrical field stimulation (EFS) has been used for decades in classical pharmacological preparations in order to characterize the mediators released by…”
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9
Long-term methylglyoxal intake aggravates murine Th2-mediated airway eosinophil infiltration
Published in International immunopharmacology (01-04-2020)“…•High levels of methylglyoxal (MGO) are found in plasma of prediabetic and diabetic patients.•Long-term MGO intake exacerbated Th2-mediated airway eosinophil…”
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10
Deletion or pharmacological blockade of TLR4 confers protection against cyclophosphamide-induced mouse cystitis
Published in American journal of physiology. Renal physiology (01-09-2018)“…Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic inflammatory disease without consistently effective treatment. We investigate the role of…”
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Methylglyoxal, a Reactive Glucose Metabolite, Induces Bladder Overactivity in Addition to Inflammation in Mice
Published in Frontiers in physiology (03-04-2020)“…Diabetic bladder dysfunction (DBD) is one of the most common complication of diabetes. Methylglyoxal (MGO), a highly reactive dicarbonyl compound formed as a…”
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Pharmacological and transcriptomic characterization of the nitric oxide pathway in aortic rings isolated from the tortoise Chelonoidis carbonaria
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01-08-2019)“…In this study the nitric oxide (NO)-soluble guanylate cyclase (sGC) and phosphodiesterase-5 (PDE-5) pathway was characterized in tortoise Chelonoidis…”
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13
6‐Nitrodopamine is an endogenous mediator of the rabbit corpus cavernosum relaxation
Published in Andrology (Oxford) (01-09-2024)“…Background 6‐Nitrodopamine (6‐ND) is a novel endogenous catecholamine that has a potent relaxant action on vascular smooth muscle in vitro. Objectives To…”
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Selective Pharmacological Inhibition of NOX2 by GSK2795039 Improves Bladder Dysfunction in Cyclophosphamide-Induced Cystitis in Mice
Published in Antioxidants (30-12-2022)“…Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory disease without consistently effective treatment. Among the many mediators…”
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15
The basal release of endothelium-derived catecholamines regulates the contractions of Chelonoidis carbonaria aorta caused by electrical-field stimulation
Published in Biology open (01-01-2021)“…The contractions of aortic rings induced by electrical field stimulation (EFS) are not inhibited by blockade of the voltage-gated sodium channels by…”
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Menthol ameliorates voiding dysfunction in types I and II diabetic mouse model
Published in Neurourology and urodynamics (01-11-2018)“…Aims Overactive bladder (OAB) is one of the most common complications of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). In healthy conditions, menthol…”
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17
Endothelium‐derived dopamine modulates EFS‐induced contractions of human umbilical vessels
Published in Pharmacology research & perspectives (01-08-2020)“…Electrical field stimulation (EFS) induces contractions of both snake aorta and human umbilical cord vessels (HUCV) which were dependent on the presence of the…”
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6-Nitrodopamine is an endogenous mediator of rat isolated epididymal vas deferens contractions induced by electric-field stimulation
Published in European journal of pharmacology (15-11-2021)“…6-nitrodopamine (6-ND) is released from human umbilical cord vessels and modulates vascular reactivity by acting as a dopamine antagonist. Here we investigate…”
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19
6-Nitrodopamine is released by human umbilical cord vessels and modulates vascular reactivity
Published in Life sciences (1973) (01-07-2021)“…Human umbilical cord vessels (HUCV) release dopamine and nitric oxide (NO). This study aims to verify whether HUCV release nitrocatecholamines such as…”
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Investigation on the positive chronotropic action of 6-nitrodopamine in the rat isolated atria
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-06-2023)“…6-Nitrodopamine (6-ND) is released from rat isolated atria being 100 times more potent than noradrenaline and adrenaline, and 10,000 times more potent than…”
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