Search Results - "Ménétrey, Julie"

Structural Biology of Arf and Rab GTPases’ Effector Recruitment and Specificity by Khan, Amir R., Ménétrey, Julie

“…Arf and Rab proteins, members of small GTPases superfamily, localize to specific subcellular compartments and regulate intracellular trafficking. To carry out…”
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An evolutionary perspective on Arf family GTPases by Jackson, Catherine L., Ménétrey, Julie, Sivia, Mandeep, Dacks, Joel B., Eliáš, Marek

“…The Arf family GTPases are regulators of eukaryotic cellular organization, functioning in the secretory and endocytic pathways, in cilia and flagella, in…”
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RAB6C Is a Retrogene that Encodes a Centrosomal Protein Involved in Cell Cycle Progression by Young, Joanne, Ménétrey, Julie, Goud, Bruno

“…Rab-GTPases are key regulators of membrane transport, and growing evidence indicates that their expression levels are altered in certain human malignancies,…”
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Toward a Structural Understanding of Arf Family:Effector Specificity by Chavrier, Philippe, Ménétrey, Julie

“…Arf family proteins are critical regulators of intracellular trafficking and actin cytoskeleton dynamics. To carry out their cellular functions, Arf family…”
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Structural Organisation of the Rotavirus Nonstructural Protein NSP5 by Martin, Davy, Ouldali, Malika, Ménétrey, Julie, Poncet, Didier

“…Rotavirus is one of the leading agents of gastroenteritis worldwide. During infection, viral factories (viroplasms) are formed. The rotavirus nonstructural…”
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Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif by Vilela, Fernando, Velours, Christophe, Chenon, Mélanie, Aumont-Nicaise, Magali, Campanacci, Valérie, Thureau, Aurélien, Pylypenko, Olena, Andreani, Jessica, Llinas, Paola, Ménétrey, Julie

“…JIP3 and JIP4 (JNK-interacting proteins 3 and 4) are adaptors for cargo recruitment by dynein/dynactin and kinesin1 motors. Both are dimers that are stabilised…”
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Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain by Nguyen, The Quyen, Chenon, Mélanie, Vilela, Fernando, Velours, Christophe, Aumont-Nicaise, Magali, Andreani, Jessica, Varela, Paloma F, Llinas, Paola, Ménétrey, Julie

“…Kinesin1 plays a major role in neuronal transport by recruiting many different cargos through its kinesin light chain (KLC). Various structurally unrelated…”
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Myosin VI Dimerization Triggers an Unfolding of a Three-Helix Bundle in Order to Extend Its Reach by Mukherjea, Monalisa, Llinas, Paola, Kim, HyeongJun, Travaglia, Mirko, Safer, Daniel, Ménétrey, Julie, Franzini-Armstrong, Clara, Selvin, Paul R., Houdusse, Anne, Sweeney, H. Lee

“…Myosin VI challenges the prevailing theory of how myosin motors move on actin: the lever arm hypothesis. While the reverse directionality and large powerstroke…”
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The structure of the myosin VI motor reveals the mechanism of directionality reversal by Houdusse, Anne, Ménétrey, Julie, Bahloul, Amel, Wells, Amber L, Yengo, Christopher M, Morris, Carl A, Sweeney, H. Lee

“…Here we solve a 2.4-A structure of a truncated version of the reverse-direction myosin motor, myosin VI, that contains the motor domain and binding sites for…”
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The Structural Basis for the Large Powerstroke of Myosin VI by Ménétrey, Julie, Llinas, Paola, Mukherjea, Monalisa, Sweeney, H. Lee, Houdusse, Anne

“…Due to a unique addition to the lever arm-positioning region (converter), class VI myosins move in the opposite direction (toward the minus-end of actin…”
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Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1) by Nguyen, T. Quyen, Aumont-Nicaise, Magali, Andreani, Jessica, Velours, Christophe, Chenon, Mélanie, Vilela, Fernando, Geneste, Clémentine, Varela, Paloma F., Llinas, Paola, Ménétrey, Julie

“…JIP1 was first identified as scaffold protein for the MAP kinase JNK and is a cargo protein for the kinesin1 molecular motor. JIP1 plays significant and broad…”
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A structural state of the myosin V motor without bound nucleotide by Sweeney, H. Lee, Houdusse, Anne, Coureux, Pierre-Damien, Wells, Amber L, Ménétrey, Julie, Yengo, Christopher M, Morris, Carl A

“…The myosin superfamily of molecular motors use ATP hydrolysis and actin-activated product release to produce directed movement and force. Although this is…”
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Structural snapshots of the kinesin‐2 OSM‐3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism by Varela, Paloma F., Chenon, Mélanie, Velours, Christophe, Verhey, Kristen J., Ménétrey, Julie, Gigant, Benoît, Wlodawer, Alex

“…Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and…”
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Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes by Ménétrey, Julie, Perderiset, Mylène, Cicolari, Jérome, Dubois, Thierry, Elkhatib, Nadia, Khadali, Fatima El, Franco, Michel, Chavrier, Philippe, Houdusse, Anne

“…ARHGAP21 is a Rho family GTPase‐activating protein (RhoGAP) that controls the Arp2/3 complex and F‐actin dynamics at the Golgi complex by regulating the…”
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The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4 by Isabet, Tatiana, Montagnac, Guillaume, Regazzoni, Karine, Raynal, Bertrand, Khadali, Fatima El, England, Patrick, Franco, Michel, Chavrier, Philippe, Houdusse, Anne, Ménétrey, Julie

“…The JNK‐interacting proteins, JIP3 and JIP4, are specific effectors of the small GTP‐binding protein ARF6. The interaction of ARF6–GTP with the second leucine…”
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Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI by Ménétrey, Julie, Isabet, Tatiana, Ropars, Virginie, Mukherjea, Monalisa, Pylypenko, Olena, Liu, Xiaoyan, Perez, Javier, Vachette, Patrice, Sweeney, H. Lee, Houdusse, Anne M.

“…Myosin VI is the only known reverse-direction myosin motor. It has an unprecedented means of amplifying movements within the motor involving rearrangements of…”
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Correction: Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain by Nguyen, The Quyen, Chenon, Mélanie, Vilela, Fernando, Velours, Christophe, Aumont-Nicaise, Magali, Andreani, Jessica, Varela, Paloma F, Llinas, Paola, Ménétrey, Julie

“…[This corrects the article DOI: 10.1371/journal.pone.0186354.]…”
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The structural GDP/GTP cycle of human Arf6 by Pasqualato, Sebastiano, Ménétrey, Julie, Franco, Michel, Cherfils, Jacqueline

“…The small GTP‐binding protein Arf6 coordinates membrane traffic at the plasma membrane with aspects of cytoskeleton organization. This function does not…”
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Structural basis for the NAD‐hydrolysis mechanism and the ARTT‐loop plasticity of C3 exoenzymes by Ménétrey, Julie, Flatau, Gilles, Boquet, Patrice, Ménez, André, Stura, Enrico A.

“…C3‐like exoenzymes are ADP‐ribosyltransferases that specifically modify some Rho GTPase proteins, leading to their sequestration in the cytoplasm, and thus…”
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The post-rigor structure of myosin VI and implications for the recovery stroke by Ménétrey, Julie, Llinas, Paola, Cicolari, Jérome, Squires, Gaëlle, Liu, Xiaoyan, Li, Anna, Sweeney, H Lee, Houdusse, Anne

“…Myosin VI has an unexpectedly large swing of its lever arm (powerstroke) that optimizes its unique reverse direction movement. The basis for this is an…”
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