Search Results - "Ménèz, Andre"

External release of entropy by synchronized movements of local secondary structures drives folding of a small, disulfide-bonded protein by Sato, Atsushi, Menez, Andre

“…A crucial mechanism to the formation of native, fully functional, 3D structures from local secondary structures is unraveled in this study. Through the…”
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Conserved structural determinants in three-fingered protein domains by Galat, Andrzej, Gross, Gregory, Drevet, Pascal, Sato, Atsushi, Ménez, André

“…The three-dimensional structures of some components of snake venoms forming so-called 'three-fingered protein' domains (TFPDs) are similar to those of the…”
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Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity by Pawlak, Joanna, Mackessy, Stephen P, Sixberry, Nicole M, Stura, Enrico A, Le Du, Marie Hélène, Ménez, Renée, Foo, Chun Shin, Ménez, André, Nirthanan, Selvanayagam, Kini, R. Manjunatha

“…A novel heterodimeric three-finger neurotoxin, irditoxin, was isolated from venom of the brown treesnake Boiga irregularis (Colubridae). Irditoxin subunit…”
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Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor by Marquer, Catherine, Fruchart-Gaillard, Carole, Letellier, Guillaume, Marcon, Elodie, Mourier, Gilles, Zinn-Justin, Sophie, Ménez, André, Servent, Denis, Gilquin, Bernard

“…The snake toxin MT7 is a potent and specific allosteric modulator of the human M1 muscarinic receptor (hM1). We previously characterized by mutagenesis…”
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Denmotoxin, a Three-finger Toxin from the Colubrid Snake Boiga dendrophila (Mangrove Catsnake) with Bird-specific Activity by Pawlak, Joanna, Mackessy, Stephen P., Fry, Bryan G., Bhatia, Madhav, Mourier, Gilles, Fruchart-Gaillard, Carole, Servent, Denis, Ménez, Renée, Stura, Enrico, Ménez, André, Kini, R. Manjunatha

“…Boiga dendrophila (mangrove catsnake) is a colubrid snake that lives in Southeast Asian lowland rainforests and mangrove swamps and that preys primarily on…”
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Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes by Roumestand, Christian, Magne, Xavier, Vita, Claudio, Lusso, Paolo, Missé, Dorothée, Pugnière, Martine, Veas, Francisco, Barthe, Philippe, Prado-Gotor, Rafael, Ménez, André, Freulon, Isabelle, Martin, Loïc, Sironi, Francesca, Stricher, François

“…The conserved surfaces of the human immunodeficiency virus (HIV)-1 envelope involved in receptor binding represent potential targets for the development of…”
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Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking by Gårdsvoll, Henrik, Gilquin, Bernard, Le Du, Marie Hélène, Ménèz, Andre, Jørgensen, Thomas J D, Ploug, Michael

“…The high affinity interaction between the serine protease urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) represents one…”
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HLA-DP4, the Most Frequent HLA II Molecule, Defines a New Supertype of Peptide-Binding Specificity by Castelli, Florence A, Buhot, Cecile, Sanson, Alain, Zarour, Hassane, Pouvelle-Moratille, Sandra, Nonn, Celine, Gahery-Segard, Hanne, Guillet, Jean-Gerard, Menez, Andre, Georges, Bertrand, Maillere, Bernard

“…Among HLA-DP specificities, HLA-DP4 specificity involves at least two molecules, HLA-DPA1*0103/DPB1*0401 (DP401) and HLA-DPA1*0103/DPB1*0402 (DP402), which…”
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Concerted Protonation of Key Histidines Triggers Membrane Interaction of the Diphtheria Toxin T Domain by Perier, Aurélie, Chassaing, Anne, Raffestin, Stéphanie, Pichard, Sylvain, Masella, Michel, Ménez, André, Forge, Vincent, Chenal, Alexandre, Gillet, Daniel

“…The translocation domain (T domain) of the diphtheria toxin contributes to the transfer of the catalytic domain from the cell endosome to the cytosol, where it…”
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Increasing the humoral immunogenic properties of the HIV-1 Tat protein using a ligand-stabilizing strategy by Lecoq, Alain, Moine, Gervaise, Bellanger, Laurent, Drevet, Pascal, Thai, Robert, Lajeunesse, Evelyne, Ménez, André, Léonetti, Michel

“…Summary Tat is regarded as an attractive target for the development of an AIDS vaccine. However, works suggest that Tat is a poorly immunogenic protein and…”
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The venom of the snake genus Atheris contains a new class of peptides with clusters of histidine and glycine residues by Favreau, Philippe, Cheneval, Olivier, Menin, Laure, Michalet, Sophie, Gaertner, Hubert, Principaud, Franck, Thai, Robert, Ménez, André, Bulet, Philippe, Stöcklin, Reto

“…We investigated venoms from members of the genus Atheris (Serpentes, Viperidae), namely the rough scale bush viper (Atheris squamigera), the green bush viper…”
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Behavior of the N-Terminal Helices of the Diphtheria Toxin T Domain during the Successive Steps of Membrane Interaction by Montagner, Caroline, Perier, Aurélie, Pichard, Sylvain, Vernier, Grégory, Ménez, André, Gillet, Daniel, Forge, Vincent, Chenal, Alexandre

“…During intoxication of a cell, the translocation (T) domain of the diphtheria toxin helps the passage of the catalytic domain across the membrane of the…”
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Antigen Stability Controls Antigen Presentation by Thai, Robert, Moine, Gervaise, Desmadril, Michel, Servent, Denis, Tarride, Jean-Luc, Ménez, André, Léonetti, Michel

“…We investigated whether protein stability controls antigen presentation using a four disulfide-containing snake toxin and three derivatives carrying one or two…”
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Scanning mutagenesis of omega-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels by Tedford, Hugo W, Gilles, Nicolas, Ménez, André, Doering, Clinton J, Zamponi, Gerald W, King, Glenn F

“…We constructed a complete panel of alanine mutants of the insect-specific calcium channel blocker omega-atracotoxin-Hv1a. Lethality assays using these mutant…”
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Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones by Llinas, Paola, Masella, Michel, Stigbrand, Torgny, Ménez, André, Stura, Enrico A., Le Du, Marie Hélène

“…Strontium is used in the treatment of osteoporosis as a ranelate compound, and in the treatment of painful scattered bone metastases as isotope. At very high…”
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Creation of intercellular bonds by anchoring protein ligands to membranes using the diphtheria toxin T domain by Perier, Aurélie, Gourier, Christine, Pichard, Sylvain, Husson, Julien, Lajeunesse, Evelyne, Babon, Aurélie, Menez, André, Gillet, Daniel

“…We describe the creation of cell adhesion mediated by cell surface engineering. The Flt3-ligand was fused to a membrane anchor made of the diphtheria toxin…”
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A high-throughput fluorescence polarization assay specific to the CD4 binding site of HIV-1 glycoproteins based on a fluorescein-labelled CD4 mimic by Stricher, François, Martin, Loïc, Barthe, Philippe, Pogenberg, Vivian, Mechulam, Alain, Menez, André, Roumestand, Christian, Veas, Francisco, Royer, Catherine, Vita, Claudio

“…The three-dimensional structure of CD4M33, a mimic of the host-cell receptor-antigen CD4 and a powerful inhibitor of CD4-gp120 (viral envelope glycoprotein…”
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Differential capacity of T cell priming in naive donors of promiscuous CD4+ T cell epitopes of HCV NS3 and Core proteins by Castelli, Florence A., Leleu, Mélanie, Pouvelle‐Moratille, Sandra, Farci, Sandrine, Zarour, Hassane M., Andrieu, Muriel, Auriault, Claude, Ménez, André, Georges, Bertrand, Maillere, Bernard

“…To understand the inter‐individual and virus‐independent variability of CD4+ T cell responses to HCV components, we evaluated the effect on these responses of…”
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HIV-1 Tat Raises an Adjuvant-free Humoral Immune Response Controlled by Its Core Region and Its Ability to Form Cysteine-mediated Oligomers by Kittiworakarn, Jongrak, Lecoq, Alain, Moine, Gervaise, Thai, Robert, Lajeunesse, Evelyne, Drevet, Pascal, Vidaud, Claude, Ménez, André, Léonetti, Michel

“…Proteins are poor immunogens that require an adjuvant to raise an immune response. Here we show that the human immunodeficiency virus, type 1 Tat protein…”
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Scorpion toxins as natural scaffolds for protein engineering by Vita, C. (Commissariat a l'Energie Atomique, Gif-sur-Yvette, France.), Roumestand, C, Toma, F, Menez, A

“…A compact, well-organized, and natural motif, stabilized by three disulfide bonds, is proposed as a basic scaffold for protein engineering. This motif contains…”
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