Search Results - "Mélik Parsadaniantz, Stéphane"

Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem by Fakih, Darine, Zhao, Zhanlin, Nicolle, Pierre, Reboussin, Elodie, Joubert, Fanny, Luzu, Jade, Labbé, Antoine, Rostène, William, Baudouin, Christophe, Mélik Parsadaniantz, Stéphane, Réaux-Le Goazigo, Annabelle

“…Dry eye disease (DED) is a multifactorial disease associated with ocular surface inflammation, pain, and nerve abnormalities. We studied the peripheral and…”
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Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions by Marek, Veronika, Mélik-Parsadaniantz, Stéphane, Villette, Thierry, Montoya, Fanny, Baudouin, Christophe, Brignole-Baudouin, Françoise, Denoyer, Alexandre

“…The ocular surface is the very first barrier between the visual system and external environment. It protects the eye from the exposure to various light sources…”
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Imaging resident and recruited macrophage contribution to Wallerian degeneration by Boissonnas, Alexandre, Louboutin, Floriane, Laviron, Marie, Loyher, Pierre-Louis, Reboussin, Elodie, Barthelemy, Sandrine, Réaux-Le Goazigo, Annabelle, Lobsiger, Christian S, Combadière, Béhazine, Mélik Parsadaniantz, Stéphane, Combadière, Christophe

“…Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MPs) of the peripheral nervous system (PNS) are…”
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Opioid and chemokine receptor crosstalk: a promising target for pain therapy? by Parsadaniantz, Stéphane Mélik, Rivat, Cyril, Rostène, William, Goazigo, Annabelle Réaux-Le

“…Chemokine receptors and opioid receptors in nociceptive pathways interact in ways that can alter opioid function. In this Progress article, Réaux-Le Goazigo…”
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Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity by Dansereau, Marc-André, Midavaine, Élora, Bégin-Lavallée, Valérie, Belkouch, Mounir, Beaudet, Nicolas, Longpré, Jean-Michel, Mélik-Parsadaniantz, Stéphane, Sarret, Philippe

“…Pain is reported as the leading cause of disability in the common forms of inflammatory arthritis conditions. Acting as a key player in nociceptive processing,…”
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Current status of chemokines in the adult CNS by Réaux-Le Goazigo, Annabelle, Van Steenwinckel, Juliette, Rostène, William, Mélik Parsadaniantz, Stéphane

“…Chemokines - chemotactic cytokines - are small secreted proteins that attract and activate immune and non-immune cells in vitro and in vivo. It has been…”
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TRPM8: A Therapeutic Target for Neuroinflammatory Symptoms Induced by Severe Dry Eye Disease by Fakih, Darine, Baudouin, Christophe, Réaux-Le Goazigo, Annabelle, Mélik Parsadaniantz, Stéphane

“…Dry eye disease (DED) is commonly associated with ocular surface inflammation and pain. In this study, we evaluated the effectiveness of repeated instillations…”
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CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury by Van Steenwinckel, Juliette, Reaux-Le Goazigo, Annabelle, Pommier, Blandine, Mauborgne, Annie, Dansereau, Marc-André, Kitabgi, Patrick, Sarret, Philippe, Pohl, Michel, Mélik Parsadaniantz, Stéphane

“…CCL2 chemokine and its receptor CCR2 may contribute to neuropathic pain development. We tested the hypothesis that injury to peripheral nerves triggers CCL2…”
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Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation? by Mélik Parsadaniantz, Stéphane, Réaux-le Goazigo, Annabelle, Sapienza, Anaïs, Habas, Christophe, Baudouin, Christophe

“…Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this…”
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Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model by Reboussin, Élodie, Buffault, Juliette, Brignole-Baudouin, Françoise, Réaux-Le Goazigo, Annabelle, Riancho, Luisa, Olmiere, Céline, Sahel, José-Alain, Mélik Parsadaniantz, Stéphane, Baudouin, Christophe

“…Glaucoma is a blinding degenerative neuropathy in which the death of retinal ganglion cells (RGCs) causes progressive loss of visual field and eventually…”
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Transient Receptor Potential Channels: Important Players in Ocular Pain and Dry Eye Disease by Fakih, Darine, Migeon, Tiffany, Moreau, Nathan, Baudouin, Christophe, Réaux-Le Goazigo, Annabelle, Mélik Parsadaniantz, Stéphane

“…Dry eye disease (DED) is a multifactorial disorder in which the eyes respond to minor stimuli with abnormal sensations, such as dryness, blurring, foreign body…”
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Lipidomic analysis of human corneal epithelial cells exposed to ocular irritants highlights the role of phospholipid and sphingolipid metabolisms in detergent toxicity mechanisms by Magny, Romain, Auzeil, Nicolas, Olivier, Elodie, Kessal, Karima, Regazzetti, Anne, Dutot, Mélody, Mélik-Parsadaniantz, Stéphane, Rat, Patrice, Baudouin, Christophe, Laprévote, Olivier, Brignole-Baudouin, Françoise

“…Detergent chemicals, widely used in household products, in pharmaceutical, medical, cosmetic and industrial fields, have been linked to side effects and…”
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The Dual Effect of Rho-Kinase Inhibition on Trabecular Meshwork Cells Cytoskeleton and Extracellular Matrix in an In Vitro Model of Glaucoma by Buffault, Juliette, Brignole-Baudouin, Françoise, Reboussin, Élodie, Kessal, Karima, Labbé, Antoine, Mélik Parsadaniantz, Stéphane, Baudouin, Christophe

“…The trabecular meshwork (TM) is the main site of drainage of the aqueous humor, and its dysfunction leads to intraocular pressure elevation, which is one of…”
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Shhedding New Light on the Role of Hedgehog Signaling in Corneal Wound Healing by Zhang, Xin, Mélik-Parsadaniantz, Stéphane, Baudouin, Christophe, Réaux-Le Goazigo, Annabelle, Moreau, Nathan

“…The cornea, an anterior ocular tissue that notably serves to protect the eye from external insults and refract light, requires constant epithelium renewal and…”
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Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice by Joubert, Fanny, Guerrero-Moreno, Adrian, Fakih, Darine, Reboussin, Elodie, Gaveriaux-Ruff, Claire, Acosta, Maria Carmen, Gallar, Juana, Sahel, José Alain, Bodineau, Laurence, Baudouin, Christophe, Rostène, William, Mélik-Parsadaniantz, Stéphane, Réaux-Le Goazigo, Annabelle

“…[Display omitted] •Corneal and trigeminal MOR expression is upregulated during corneal pain.•Chronic topical DAMGO reduces ciliary nerve…”
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Implication of Melanopsin and Trigeminal Neural Pathways in Blue Light Photosensitivity in vivo by Marek, Veronika, Reboussin, Elodie, Dégardin-Chicaud, Julie, Charbonnier, Angéline, Domínguez-López, Alfredo, Villette, Thierry, Denoyer, Alexandre, Baudouin, Christophe, Réaux-Le Goazigo, Annabelle, Mélik Parsadaniantz, Stéphane

“…Photophobia may arise from various causes and frequently accompanies numerous ocular diseases. In modern highly illuminated world, complaints about greater…”
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Deepening of lipidome annotation by associating cross-metathesis reaction with mass spectrometry: application to an in vitro model of corneal toxicity by Magny, Romain, Regazzetti, Anne, Kessal, Karima, Baudouin, Christophe, Mélik-Parsadaniantz, Stéphane, Laprévote, Olivier, Brignole-Baudouin, Françoise, Auzeil, Nicolas, Roulland, Emmanuel

“…The in-depth knowledge of lipid biological functions needs a comprehensive structural annotation including a method to locate fatty acid unsaturations, which…”
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Lipid Annotation by Combination of UHPLC-HRMS (MS), Molecular Networking, and Retention Time Prediction: Application to a Lipidomic Study of In Vitro Models of Dry Eye Disease by Magny, Romain, Regazzetti, Anne, Kessal, Karima, Genta-Jouve, Gregory, Baudouin, Christophe, Mélik-Parsadaniantz, Stéphane, Brignole-Baudouin, Françoise, Laprévote, Olivier, Auzeil, Nicolas

“…Annotation of lipids in untargeted lipidomic analysis remains challenging and a systematic approach needs to be developed to organize important datasets with…”
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Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation by Callewaere, Céline, Banisadr, Ghazal, Rostène, William, Parsadaniantz, Stéphane Mélik

“…Chemokines are small secreted proteins that chemoattract and activate immune and non-immune cells both in vivo and in vitro. In addition to their…”
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The Chemokine SDF-1/CXCL12 Modulates the Firing Pattern of Vasopressin Neurons and Counteracts Induced Vasopressin Release through CXCR4 by Callewaere, Céline, Banisadr, Ghazal, Desarménien, Michel G., Mechighel, Patricia, Kitabgi, Patrick, Rostène, William H., Parsadaniantz, Stéphane Mélik

“…Chemokines play a key role in inflammation. They are expressed not only in neuroinflammatory conditions, but also constitutively by different cell types,…”
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