Search Results - "Mångs, Helena"

The Human Pseudoautosomal Region (PAR): Origin, Function and Future by Helena Mangs, A, Morris, Brian J

“…The pseudoautosomal regions (PAR1 and PAR2) of the human X and Y chromosomes pair and recombine during meiosis. Thus genes in this region are not inherited in…”
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ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome by Yang, Yee Hwa J., Markus, M. Andrea, Mangs, A. Helena, Raitskin, Oleg, Sperling, Ruth, Morris, Brian J.

“…Alternative splicing is a major source of protein diversity in humans. The human splicing factor zinc finger, Ran-binding domain containing protein 2 (ZRANB2)…”
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HADHB, HuR, and CP1 Bind to the Distal 3′-Untranslated Region of Human Renin mRNA and Differentially Modulate Renin Expression by Adams, David J., Beveridge, Dianne J., van der Weyden, Louise, Mangs, Helena, Leedman, Peter J., Morris, Brian J.

“…Production of renin is critically dependent on modulation of REN mRNA stability. Here we sought to elucidate the molecular mechanisms involved. Transfections…”
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The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms by KOVACEVIC, Zaklina, SIVAGURUNATHAN, Sutharshani, MANGS, Helena, CHIKHANI, Sherin, DAOHAI ZHANG, RICHARDSON, Des R

“…The metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), has been shown to markedly reduce metastasis of numerous tumors. The current study was…”
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ZRANB2: Structural and functional insights into a novel splicing protein by Mangs, A. Helena, Morris, Brian J.

“…ZRANB2 was identified originally in a differential display experiment on 2-day and 10-day primary cultures of rat juxtaglomerular cells. During prolonged…”
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Methylation-capture and Next-Generation Sequencing of free circulating DNA from human plasma by Warton, Kristina, Lin, Vita, Navin, Tina, Armstrong, Nicola J, Kaplan, Warren, Ying, Kevin, Gloss, Brian, Mangs, Helena, Nair, Shalima S, Hacker, Neville F, Sutherland, Robert L, Clark, Susan J, Samimi, Goli

“…Free circulating DNA (fcDNA) has many potential clinical applications, due to the non-invasive way in which it is collected. However, because of the low…”
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PAI-1 stability: the role of histidine residues by Mångs, Helena, Sui, Guang-Chao, Wiman, Björn

“…The role of the 13 histidine residues in plasminogen activator inhibitor 1 (PAI-1) for the stability of the molecule was studied by replacing these residues by…”
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XE7: A novel splicing factor that interacts with ASF/SF2 and ZNF265 by Mangs, A. Helena, Speirs, Helen J.L, Goy, Christine, Adams, David J, Markus, M. Andrea, Morris, Brian J

“…Pre-mRNA splicing is performed by the spliceosome. SR proteins in this macromolecular complex are essential for both constitutive and alternative splicing. By…”
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Abstract A4: Whole genome sequencing of free circulating DNA from plasma of HGSOC patients by Warton, Kristina, Vita, Lin, Armstrong, Nicola J., Kaplan, Warren, Ying, Kevin, Mangs, Helena, Hacker, Neville F., Sutherland, Robert L., Clark, Susan J., Samimi, Goli

“…Genomic analysis of free circulating DNA (fcDNA) has a number of potential clinical applications, including cancer studies. Tumor-derived fcDNA harbors the…”
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WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo by Markus, M. Andrea, Heinrich, Bettina, Raitskin, Oleg, Adams, David J., Mangs, Helena, Goy, Christine, Ladomery, Michael, Sperling, Ruth, Stamm, Stefan, Morris, Brian J.

“…Wilm's tumor protein 1 (WT1), a protein implicated in various cancers and developmental disorders, consists of two major isoforms: WT1(−KTS), a transcription…”
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Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer by Assinder, Stephen J, Dong, Qihan, Mangs, Helena, Richardson, Des R

“…Prostate cancer is a highly heterogenous disease in which a patient-tailored care program is much desired. Central to this goal is the development of novel…”
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Abstract B172: The metastasis suppressor NDRG1 up-regulates p21 in a p53-independent manner in cancer cells: A novel insight into its antitumor function by Kovacevic, Zaklina, Sivagurunathan, Sutharshani, Mangs, Helena, Chikhani, Sherin, Richardson, Des R.

“…A recently identified metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), has been shown to reduce the invasion and metastasis of numerous…”
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The role of His(143) for the pH-dependent stability of plasminogen activator inhibitor-1 by Sui, G C, Mångs, H, Wiman, B

“…Using site-directed mutagenesis, His(143) on the alpha-helix F of PAI-1 was substituted by Lys, Asp, Phe and Thr, respectively. The generated single-site…”
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The role of His143 for the pH-dependent stability of plasminogen activator inhibitor-1 by Sui, Guang-Chao, Mångs, Helena, Wiman, Björn

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HADHB, HuR, and CP1 Bind to the Distal 3′-Untranslated Region of Human Renin mRNA and Differentially Modulate Renin Expression by David J. Adams, Dianne J. Beveridge, Louise van der Weyden, Helena Mangs, Peter J. Leedman, Brian J. Morris

“…Production of renin is critically dependent on modulation of REN mRNA stability. Here we sought to elucidate the molecular mechanisms involved. Transfections…”
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The role of His 143 for the pH-dependent stability of plasminogen activator inhibitor-1 by Sui, Guang-Chao, Mångs, Helena, Wiman, Björn

“…Using site-directed mutagenesis, His 143 on the α-helix F of PAI-1 was substituted by Lys, Asp, Phe and Thr, respectively. The generated single-site changed…”
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