Search Results - "Männistö, P.T"

On the role of prolyl oligopeptidase in health and disease by Garcia-Horsman, JA, Maennistoe, P T, Venaelaeinen, JI

“…Abstract Prolyl oligopeptidase (POP) is a serine peptidase which digests small peptide-like hormones, neuroactive peptides, and various cellular factors…”
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Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson’s and Alzheimer’s diseases by Hannula, M.J, Myöhänen, T.T, Tenorio-Laranga, J, Männistö, P.T, Garcia-Horsman, J.A

“…Highlights • Serine protease, prolyl oligopeptidase, accelerates the aggregation of α-synuclein. • Prolyl oligopeptidase colocalizes with marker proteins of…”
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Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo by Piltonen, M, Planken, A, Leskelä, O, Myöhänen, T.T, Hänninen, A.-L, Auvinen, P, Alitalo, K, Andressoo, J.-O, Saarma, M, Männistö, P.T

“…Abstract Neurotrophic factors regulate the development and maintenance of the nervous system and protect and repair dopaminergic neurons in animal models of…”
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Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging by Moreno-Baylach, M.J, Felipo, V, Männistö, P.T, García-Horsman, J.A

“…Abstract Prolyl oligopeptidase (POP) is an endopeptidase which cleaves short proline-containing neuropeptides, and it is involved in memory and learning. POP…”
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Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains by Piltonen, M, Savolainen, M, Patrikainen, S, Baekelandt, V, Myöhänen, T.T, Männistö, P.T

“…Highlights ► Transgenic tg(Prnp-SNCA∗ A30P)-mice develop motor deficits with age. ► tg(Prnp-SNCA∗ A30P) Tg mice have a reduced locomotor response to…”
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3.132 COMPARISON OF FOUR GDNF-VARIANTS IN THE 6-OHDA RAT MODEL OF PARKINSON'S DISEASE by Piltonen, M.H, Bespalov, M.M, Männistö, P.T

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Corrigendum to “Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson’s and Alzheimer’s diseases” [Neuroscience 242 (2013) 140–150] by Hannula, M.J, Myöhänen, T.T, Tenorio-laranga, J, Männistö, P.T, Garcia-horsman, J.A

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Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: An immunohistochemical colocalization study by Myohanen, T T, Venalainen, JI, Garcia-Horsman, JA, Mannisto, P T

“…Abstract Prolyl oligopeptidase (POP) is a serine endopeptidase which hydrolyzes proline-containing peptides shorter than 30 amino acids. It has been suggested…”
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3.221 AMANTADINE PROTECTS DOPAMINE NEURONS BY A DUAL ACTION: REDUCING ACTIVATION OF MICROGLIA AND INDUCING EXPRESSION OF GNDF IN ASTROGLIA by Ossola, B, Schendzielorz, N, Chen, S.-H, Bird, G.S, Tuominen, R.K, Männistö, P.T, Hong, J.-S

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P1.051 Selective inhibition of dopamine and noradrenaline transporters (DAT & NET) in the prefrontal cortex of COMT knock-out mice by Käenmäki, M, Amberg, C, Männistö, P.T

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S.1.03 Nicotine-opioid interactions: in vitro and in vivo studies by Tuominen, R.K, Talka, R, Kivinummi, T, Pakkanen, J.S, Nuutinen, S, Ahtee, L, Piepponen, T.P, Männistö, P.T, Salminen, O

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P.2.013 Reinforcing effects of cocaine in COMT knockout mice by Mus, L.V, Dravolina, O.A, Bespalov, A.Y, Käenmäki, M, Salminen, O, Tuominen, R.K, Männistö, P.T, Zvartau, E.E

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P2.016 Neuroprotective effects of VEGF-C in the 6-OHDA rat model of Parkinson's disease by Piltonen, M, Planken, A, Leskelä, O, Saarma, M, Männistö, P.T

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P1.052 Striatal catechol-O-methyltransferase after selective 6-OHDA lesions in the rat by Schendzielorz, N, Oinas, J.-P, Reenilä, I, Männistö, P.T

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P2.002 Intranigral injection of CDNF promotes functional recovery of nigrostriatal dopaminergic circuit in a lesion model of Parkinson's disease by Bäck, S, Airavaara, M, Miranto, H, Voutilainen, M.H, Hoffer, B, Männistö, P.T, Raasmaja, A, Saarma, M, Tuominen, R.K

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Prolyl oligopeptidase (POP), a multifunction protein by Gracía-Horsman, J.A., Männistö, P.T.

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Importance of the two forms of catechol- O-methyltransferase (COMT) in l-dopa metabolism: a pharmacokinetic study in COMT knock-out mice and in mice lacking soluble COMT by Käenmäki, Mikko, Tammimäki, A., Männistö, P.T.

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Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A by Rauhavirta, T, Qiao, S.-W, Jiang, Z, Myrsky, E, Loponen, J, Korponay-Szabó, I.R, Salovaara, H, Garcia-Horsman, J.A, Venäläinen, J, Männistö, P.T, Collighan, R, Mongeot, A, Griffin, M, Mäki, M, Kaukinen, K, Lindfors, K

“…In coeliac disease, the intake of dietary gluten induces small-bowel mucosal damage and the production of immunoglobulin (Ig)A class autoantibodies against…”
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Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells by Stenman, S.M, Lindfors, K, Venäläinen, J.I, Hautala, A, Männistö, P.T, Garcia-Horsman, J.A, Kaukovirta-Norja, A, Auriola, S, Mauriala, T, Mäki, M, Kaukinen, K

“…Currently the only treatment for coeliac disease is a lifelong gluten-free diet excluding food products containing wheat, rye and barley. There is, however,…”
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Effect of COMT gene disruption on extracellular dopamine concentration as measured by quantitative no-net-flux microdialysis by Tammimäki, Anne, Pakarinen, K., Käenmäki, M., Männistö, P.T.

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