Search Results - "Mátrai, Janka"

Recent Advances in Lentiviral Vector Development and Applications by Mátrai, Janka, Chuah, Marinee KL, VandenDriessche, Thierry

“…Lentiviral vectors (LVs) have emerged as potent and versatile vectors for ex vivo or in vivo gene transfer into dividing and nondividing cells. Robust…”
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International Comparison of Enumeration-Based Quantification of DNA Copy-Concentration Using Flow Cytometric Counting and Digital Polymerase Chain Reaction by Yoo, Hee-Bong, Park, Sang-Ryoul, Dong, Lianhua, Wang, Jing, Sui, Zhiwei, Pavšič, Jernej, Milavec, Mojca, Akgoz, Muslum, Mozioğlu, Erkan, Corbisier, Philippe, Janka, Mátrai, Cosme, Bruno, de V. Cavalcante, Janaina J, Flatshart, Roberto Becht, Burke, Daniel, Forbes-Smith, Michael, McLaughlin, Jacob, Emslie, Kerry, Whale, Alexandra S, Huggett, Jim F, Parkes, Helen, Kline, Margaret C, Harenza, Jo Lynne, Vallone, Peter M

“…Enumeration-based determination of DNA copy-concentration was assessed through an international comparison among national metrology institutes (NMIs) and…”
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Understanding the Role of Defective Invertases in Plants: Tobacco Nin88 Fails to Degrade Sucrose by Le Roy, Katrien, Vergauwen, Rudy, Struyf, Tom, Yuan, Shuguang, Lammens, Willem, Mátrai, Janka, De Maeyer, Marc, Van den Ende, Wim

“…Cell wall invertases (cwINVs), with a high affinity for the cell wall, are fundamental enzymes in the control of plant growth, development, and carbon…”
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Hepatocyte‐targeted expression by integrase‐defective lentiviral vectors induces antigen‐specific tolerance in mice with low genotoxic risk by Mátrai, Janka, Cantore, Alessio, Bartholomae, Cynthia C., Annoni, Andrea, Wang, Wei, Acosta‐Sanchez, Abel, Samara‐Kuko, Ermira, De Waele, Liesbeth, Ma, Ling, Genovese, Pietro, Damo, Martina, Arens, Anne, Goudy, Kevin, Nichols, Timothy C., von Kalle, Christof, L. Chuah, Marinee K., Roncarolo, Maria Grazia, Schmidt, Manfred, VandenDriessche, Thierry, Naldini, Luigi

“…Lentiviral vectors are attractive tools for liver‐directed gene therapy because of their capacity for stable gene expression and the lack of preexisting…”
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Novel Hyperactive Transposons for Genetic Modification of Induced Pluripotent and Adult Stem Cells: A Nonviral Paradigm for Coaxed Differentiation by Belay, Eyayu, Mátrai, Janka, Acosta‐Sanchez, Abel, Ma, Ling, Quattrocelli, Mattia, Mátés, Lajos, Sancho‐Bru, Pau, Geraerts, Martine, Yan, Bing, Vermeesch, Joris, Rincón, Melvin Yesid, Samara‐Kuko, Ermira, Ivics, Zoltán, Verfaillie, Catherine, Sampaolesi, Maurilio, Izsvák, Zsuzsanna, VandenDriessche, Thierry, Chuah, Marinee K. L.

“…Adult stem cells and induced pluripotent stem cells (iPS) hold great promise for regenerative medicine. The development of robust nonviral approaches for stem…”
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Preclinical and clinical progress in hemophilia gene therapy by Mátrai, Janka, Chuah, Marinee KL, VandenDriessche, Thierry

“…PURPOSE OF REVIEWHemophilia A and B are attractive target diseases for gene therapy, as stable expression of coagulation factor VIII and IX may correct the…”
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An alternate sucrose binding mode in the E203Q Arabidopsis invertase mutant: An X-ray crystallography and docking study by Mátrai, Janka, Lammens, Willem, Jonckheer, Abel, Le Roy, Katrien, Rabijns, Anja, Van den Ende, Wim, De Maeyer, Marc

“…In the present study, we report on the X‐ray crystallographic structure of a GH32 invertase mutant, (i.e., the Arabidopsis thaliana cell‐wall invertase…”
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Combined molecular and supramolecular bottom-up nanoengineering for enhanced nonlinear optical response: experiments, modeling, and approaching the fundamental limit by Pérez-Moreno, Javier, Asselberghs, Inge, Song, Kai, Clays, Koen, Zhao, Yuxia, Nakanishi, Hachiro, Okada, Shuji, Nogi, Kyoko, Kim, Oh-Kil, Je, Jongtae, Mátrai, Janka, De Maeyer, Marc, Kuzyk, Mark G

“…The authors study the combination of two independent strategies that enhance the hyperpolarizability of ionic organic chromophores. The first molecular-level…”
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Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates by Chuah, Marinee K L, Ma, Ling, VandenDriessche, Thierry, Manoj, Namitha, Samara-Kuko, Ermira, Grzela, Dawid P, Schmitt, Andrea, Pryputniewicz, Diana, Fletcher, Bradley, Jerchow, Boris, Mátés, Lajos, Matrai, Janka, Gysemans, Conny, Becker, Katja, Miskey, Csaba, Belay, Eyayu, Acosta-Sanchez, Abel, Ivics, Zoltán, Izsvák, Zsuzsanna

“…Zsuzsanna Izsvák and colleagues report the generation of a hyperactive version of the Sleeping Beauty transposase that supports efficient and stable gene…”
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Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice by Cantore, Alessio, Nair, Nisha, Della Valle, Patrizia, Di Matteo, Mario, Màtrai, Janka, Sanvito, Francesca, Brombin, Chiara, Di Serio, Clelia, D'Angelo, Armando, Chuah, Marinee, Naldini, Luigi, VandenDriessche, Thierry

“…Gene therapy may provide a cure for hemophilia and overcome the limitations of protein replacement therapy. Increasing the potency of gene transfer vectors may…”
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Simulation of the activation of α‐chymotrypsin: Analysis of the pathway and role of the propeptide by Mátrai, Janka, Verheyden, Gert, Krüger, Peter, Engelborghs, Yves

“…α‐Chymotrypsin undergoes a reversible conformational change from an inactive chymotrypsinogen‐like structure at high pH to an active conformation at neutral…”
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Understanding the Role of Defective Invertases in Plants: Tobacco Nin88 Fails to Degrade Sucrose1[W] by Le Roy, Katrien, Vergauwen, Rudy, Struyf, Tom, Yuan, Shuguang, Lammens, Willem, Mátrai, Janka, De Maeyer, Marc, Van den Ende, Wim

“…An inactive invertase may indirectly stimulate the activity of active cell wall invertases. Cell wall invertases ( cwINVs ), with a high affinity for the cell…”
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PiggyBac toolbox by Di Matteo, Mario, Mátrai, Janka, Belay, Eyayu, Firdissa, Tewodros, Vandendriessche, Thierry, Chuah, Marinee K L

“…The PiggyBac (PB) transposon system was originally derived from the cabbage looper moth Trichoplusia ni and represents one of the most promising transposon…”
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Exploration of the activation pathway of Δα-Chymotrypsin with molecular dynamics simulations and correlation with kinetic experiments by Mátrai, Janka, Jonckheer, Abel, Joris, Eddy, Krüger, Peter, Carpenter, Eric, Tuszynski, Jack, De Maeyer, Marc, Engelborghs, Yves

“…Correlating the experimentally observed kinetics of protein conformational changes with theoretical predictions is a formidable and challenging task, due to…”
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Comparative Analysis of Transposable Element Vector Systems in Human Cells by Grabundzija, Ivana, Irgang, Markus, Mátés, Lajos, Belay, Eyayu, Matrai, Janka, Gogol-Döring, Andreas, Kawakami, Koichi, Chen, Wei, Ruiz, Patricia, Chuah, Marinee K.L., VandenDriessche, Thierry, Izsvák, Zsuzsanna, Ivics, Zoltán

“…Transposon-based gene vectors have become indispensable tools in vertebrate genetics for applications ranging from insertional mutagenesis and transgenesis in…”
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Exploration of the activation pathway of [Delta][alpha]-Chymotrypsin with molecular dynamics simulations and correlation with kinetic experiments by Mátrai, Janka, Jonckheer, Abel, Joris, Eddy, Krüger, Peter, Carpenter, Eric, Tuszynski, Jack, De Maeyer, Marc, Engelborghs, Yves

“…Correlating the experimentally observed kinetics of protein conformational changes with theoretical predictions is a formidable and challenging task, due to…”
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Genome-wide Computational Analysis Reveals Cardiomyocyte-specific Transcriptional Cis-regulatory Motifs That Enable Efficient Cardiac Gene Therapy by Rincon, Melvin Y, Sarcar, Shilpita, Danso-Abeam, Dina, Keyaerts, Marleen, Matrai, Janka, Samara-Kuko, Ermira, Acosta-Sanchez, Abel, Athanasopoulos, Takis, Dickson, George, Lahoutte, Tony, De Bleser, Pieter, VandenDriessche, Thierry, Chuah, Marinee K

“…Gene therapy is a promising emerging therapeutic modality for the treatment of cardiovascular diseases and hereditary diseases that afflict the heart. Hence,…”
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Liver-Specific Transcriptional Modules Identified by Genome-Wide In Silico Analysis Enable Efficient Gene Therapy in Mice and Non-Human Primates by Chuah, Marinee K, Petrus, Inge, De Bleser, Pieter, Le Guiner, Caroline, Gernoux, Gwladys, Adjali, Oumeya, Nair, Nisha, Willems, Jessica, Evens, Hanneke, Rincon, Melvin Y, Matrai, Janka, Di Matteo, Mario, Samara-Kuko, Ermira, Yan, Bing, Acosta-Sanchez, Abel, Meliani, Amine, Cherel, Ghislaine, Blouin, Véronique, Christophe, Olivier, Moullier, Philippe, Mingozzi, Federico, VandenDriessche, Thierry

“…The robustness and safety of liver-directed gene therapy can be substantially improved by enhancing expression of the therapeutic transgene in the liver. To…”
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Exploration of the activation pathway of Deltaalpha-Chymotrypsin with molecular dynamics simulations and correlation with kinetic experiments by Mátrai, Janka, Jonckheer, Abel, Joris, Eddy, Krüger, Peter, Carpenter, Eric, Tuszynski, Jack, De Maeyer, Marc, Engelborghs, Yves

“…Correlating the experimentally observed kinetics of protein conformational changes with theoretical predictions is a formidable and challenging task, due to…”
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Mechanism of the Ring−Chain Rearrangement in Phosphiranes:  Hydrogen versus Halogen Migration by Mátrai, Janka, Dransfeld, Alk, Veszprémi, Tamás, Nguyen, Minh Tho

“…Ab initio quantum chemical calculations including HF, MP2, CCSD(T), CASSCF(10,10)/CASPT2, and B3LYP methods with the 6-31G(d,p) basis set were used to probe…”
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