Search Results - "Márquez, Chantal L."
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IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
Published in eLife (31-05-2018)“…The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores…”
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Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis
Published in eLife (07-06-2018)“…Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. To…”
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Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
Published in eLife (13-02-2024)“…The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug…”
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Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses
Published in Viruses (27-05-2022)“…Pyridobenzothiazolone derivatives are a promising class of broad-spectrum antivirals. However, the mode of action of these compounds remains poorly understood…”
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Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A
Published in Retrovirology (04-04-2019)“…Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to…”
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Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc
Published in PLoS neglected tropical diseases (14-07-2016)“…Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope…”
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Fluorescence Microscopy Assay to Measure HIV-1 Capsid Uncoating Kinetics in vitro
Published in Bio-protocol (05-07-2019)“…The stability of the HIV-1 capsid and the spatiotemporal control of its disassembly, a process called uncoating, need to be finely tuned for infection to…”
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Strategies for Success. Viral Infections and Membraneless Organelles
Published in Frontiers in cellular and infection microbiology (11-10-2019)“…Regulation of RNA homeostasis or "RNAstasis" is a central step in eukaryotic gene expression. From transcription to decay, cellular messenger RNAs (mRNAs)…”
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Hantavirus Gn and Gc Glycoproteins Self-Assemble into Virus-Like Particles
Published in Journal of Virology (01-02-2014)“…Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Tellurite Promotes Stress Granules and Nuclear SG-Like Assembly in Response to Oxidative Stress and DNA Damage
Published in Frontiers in cell and developmental biology (11-02-2021)“…Tellurium oxyanion, tellurite ( ), is a highly toxic compound for many organisms. Its presence in the environment has increased over the past years due to…”
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Negative Staining Transmission Electron Microscopy of HIV Viral Particles Permeabilized with PFO and Capsid Stabilized with IP6
Published in Bio-protocol (20-10-2022)“…The human immunodeficiency virus 1 (HIV-1) consists of a viral membrane surrounding the conical capsid. The capsid is a protein container assembled from…”
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Hantavirus Gn and Gc glycoproteins self-assemble into virus-like particles
Published in Journal of virology (01-02-2014)“…How hantaviruses assemble and exit infected cells remains largely unknown. Here, we show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn…”
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