Search Results - "Mándity, István"

ConjuPepDB: a database of peptide–drug conjugates by Balogh, Balázs, Ivánczi, Márton, Nizami, Bilal, Beke-Somfai, Tamás, Mándity, István M

“…Abstract Peptide–drug conjugates are organic molecules composed of (i) a small drug molecule, (ii) a peptide and (iii) a linker. The drug molecule is mandatory…”
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Highly functionalized cyclic β-amino acid moieties as promising scaffolds in peptide research and drug design by Kiss, Loránd, Mándity, István M., Fülöp, Ferenc

“…Peptide-based drug research has received high attention in the field of medicinal chemistry over the past decade. For drug design, to improve proteolytic…”
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Continuous-Flow Solid-Phase Peptide Synthesis: A Revolutionary Reduction of the Amino Acid Excess by Mándity, István M., Olasz, Balázs, Ötvös, Sándor B., Fülöp, Ferenc

“…A highly efficient continuous‐flow technique for the synthesis of peptides was developed. The method allows the application of only 1.5 equivalents of amino…”
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Polymerization‐Driven Photoluminescence in Alkanolamine‐Based C‐Dots by Ludmerczki, Robert, Malfatti, Luca, Stagi, Luigi, Meloni, Manuela, Carbonaro, Carlo Maria, Casula, Maria Francesca, Bogdán, Dóra, Mura, Stefania, Mándity, István M., Innocenzi, Plinio

“…Carbonized polymer dots (CPDs), a peculiar type of carbon dots, show extremely high quantum yields, making them very attractive nanostructures for application…”
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Harnessing the Versatility of Continuous-Flow Processes: Selective and Efficient Reactions by Mandity, István M, Otvos, Sándor B, Szlsi, György, Fulop, Ferenc

“…There is a great need for effective transformations and a broad range of novel chemical entities. Continuous‐flow (CF) approaches are of considerable current…”
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Sustainable and Safe N -alkylation of N -heterocycles by Propylene Carbonate under Neat Reaction Conditions by Czompa, Andrea, Bogdán, Dóra, Balogh, Balázs, Erdei, Eszter, Selymes, Patrik, Csomos, Attila, Mándity, István M

“…A new, eco-friendly process utilising the green solvent propylene carbonate (PC) has been developed to perform -alkylation of -, - and/or -containing…”
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Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide by Ötvös, Sándor B., Mándity, István M., Fülöp, Ferenc

“…A continuous-flow process was developed for asymmetric aldol reactions utilizing an immobilized peptide as organocatalyst, readily synthesized and immobilized…”
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Advantages of Induced Circular Dichroism Spectroscopy for Qualitative and Quantitative Analysis of Solution-Phase Cyclodextrin Host-Guest Complexes by Kraszni, Márta, Balogh, Balázs, Mándity, István, Horváth, Péter

“…The presence of a chiral or chirally perturbed chromophore in the molecule under investigation is a fundamental requirement for the appearance of a circular…”
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N -Acetylation of Amines in Continuous-Flow with Acetonitrile-No Need for Hazardous and Toxic Carboxylic Acid Derivatives by Orsy, György, Fülöp, Ferenc, Mándity, István M

“…A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method…”
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An overview of peptide and peptoid foldamers in medicinal chemistry by Mándity, István M, Fülöp, Ferenc

“…Foldamers are artificial self-organizing systems with various critical properties: i) a stable and designable secondary structure; ii) a larger molecular…”
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Statin‐boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential by Batta, Gyula, Kárpáti, Levente, Henrique, Gabriela Fulaneto, Tóth, Gabriella, Tarapcsák, Szabolcs, Kovacs, Tamas, Zakany, Florina, Mándity, István M., Nagy, Peter

“…Background and Purpose Cell penetrating peptides are promising tools for delivery of cargo into cells, but factors limiting or facilitating their cellular…”
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Strategic Application of Residence‐Time Control in Continuous‐Flow Reactors by Mandity, Istvan M, Oetvos, Sandor B, Fuelop, Ferenc

“…As a sustainable alternative for conventional batch‐based synthetic techniques, the concept of continuous‐flow processing has emerged in the synthesis of fine…”
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Physicochemical Profiling of Baicalin Along with the Development and Characterization of Cyclodextrin Inclusion Complexes by Jakab, Géza, Bogdán, Dóra, Mazák, Károly, Deme, Ruth, Mucsi, Zoltán, Mándity, István M., Noszál, Béla, Kállai-Szabó, Nikolett, Antal, István

“…Baicalin is a flavone glycoside extracted from Scutellaria baicalensis , a traditional Chinese herbal medicine. Numerous pharmacological effects of baicalin…”
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Molecular Dynamics Simulations of Drug-Conjugated Cell-Penetrating Peptides by Ivánczi, Márton, Balogh, Balázs, Kis, Loretta, Mándity, István

“…Cell-penetrating peptides (CPPs) are small peptides capable of translocating through biological membranes carrying various attached cargo into cells and even…”
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Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution by Németh, András Gy, Szabó, Renáta, Orsy, György, Mándity, István M, Keserű, György M, Ábrányi-Balogh, Péter

“…We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The…”
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Continuous‐Flow retro‐Diels–Alder Reaction: A Process Window for Designing Heterocyclic Scaffolds by Nekkaa, Imane, Palkó, Márta, Mándity, István M., Miklós, Ferenc, Fülöp, Ferenc

“…The synthesis of racemic and enantiopure tricyclic and tetracyclic pyrrolopyrimidinones, pyrimidoisoindoles, and spiropyrimidinones, as valuable new chemical…”
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Design of Peptidic Foldamer Helices: A Stereochemical Patterning Approach by Mándity, István M, Wéber, Edit, Martinek, Tamás A, Olajos, Gábor, Tóth, Gábor K, Vass, Elemér, Fülöp, Ferenc

“…Assembly language: The programmed sequences of stereochemical building blocks lead to novel biomimetic helices. The rational design approach offers new…”
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Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides by Zakany, Florina, Mándity, István M, Varga, Zoltan, Panyi, Gyorgy, Nagy, Peter, Kovacs, Tamas

“…Every cell biological textbook teaches us that the main role of the plasma membrane is to separate cells from their neighborhood to allow for a controlled…”
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Unique α,β- and α,α,β,β-Peptide Foldamers Based on cis-β-Aminocyclopentanecarboxylic Acid by Berlicki, Łukasz, Pilsl, Ludwig, Wéber, Edit, Mándity, István M., Cabrele, Chiara, Martinek, Tamás A., Fülöp, Ferenc, Reiser, Oliver

“…Waterproof: cis‐β‐Aminocylopentanecarboxylic acid is a highly suitable building block for the synthesis of α,β‐ and α,α,β,β‐peptides that have unique helical…”
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Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins: Organocatalysis in Continuous Flow by Solid-Supported Peptidic Catalysts by Ötvös, Sándor B., Mándity, István M., Fülöp, Ferenc

“…Michael's peptides: A simple and efficient continuous flow technique has been developed for the organocatalytic Michael reactions using solid‐supported…”
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