Search Results - "MÜLSCH, A"

Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure by Daiber, Andreas, Oelze, Matthias, Coldewey, Meike, Kaiser, K., Huth, C., Schildknecht, S., Bachschmid, M., Nazirisadeh, Y., Ullrich, V., Mülsch, A., Münzel, T., Tsilimingas, N.

“…The hemodynamic and anti-ischemic effects of nitroglycerin (GTN) are rapidly blunted as a result of the development of nitrate tolerance. Hydralazine has been…”
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Nitric oxide inhibits caspase-3 by S-nitrosation in vivo by Rössig, L, Fichtlscherer, B, Breitschopf, K, Haendeler, J, Zeiher, A M, Mülsch, A, Dimmeler, S

“…In cultured human endothelial cells, physiological levels of NO prevent apoptosis and interfere with the activation of the caspase cascade. In vitro data have…”
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Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells by Busse, Rudi, Mülsch, Alexander

“…We investigated the mechanisms by which cytokines lead to a diminished responsiveness of vascular smooth muscle to vasoconstrictors. The attenuation of…”
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The effect of peroxynitrite on the catalytic activity of soluble guanylyl cyclase by Weber, Martina, Lauer, Nadine, Mülsch, Alexander, Kojda, Georg

“…Soluble guanylyl cyclase (sGC) is a key enzyme of the •NO/cGMP pathway. Many cardiovascular disorders are associated with reduced •NO-mediated effects, while…”
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Aging and Chronic Hypertension Decrease Expression of Rat Aortic Soluble Guanylyl Cyclase by Klob, Stephan, Bouloumie, Anne, Mulsch, Alexander

“…We analyzed the influence of aging and genetic hypertension on the function and expression of soluble guanylyl cyclase (sGC) in the aortas of prehypertensive…”
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Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta by MÜLSCH, Alexander, OELZE, Matthias, MEINERTZ, Thomas, MÜNZEL, Thomas, KLÖSS, Stefan, MOLLNAU, Hanke, TOPFER, Andrea, SMOLENSKI, Albert, WALTER, Ulrich, STASCH, Johannes-Peter, WARNHOLTZ, Ascan, HINK, Ulrich

“…Chronic in vivo treatment with nitroglycerin (NTG) induces tolerance to nitrates and cross-tolerance to nitrovasodilators and endothelium-derived nitric oxide…”
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Validation of Lucigenin as a Chemiluminescent Probe to Monitor Vascular Superoxide as Well as Basal Vascular Nitric Oxide Production by Skatchkov, Mikhail P., Sperling, Daniel, Hink, Ulrich, Mülsch, Alexander, Harrison, David G., Sindermann, Irene, Meinertz, Thomas, Münzel, Thomas

“…Lucigenin has been widely used as a chemiluminescent substrate to monitor vascular superoxide (O•−2) formation. The validity of lucigenin for detection of…”
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Vasodilator dysfunction in aged spontaneously hypertensive rats : Changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production by BAUERSACHS, J, BOULOUMIE, A, MÜLSCH, A, WIEMER, G, FLEMING, I, BUSSE, R

“…Genetic hypertension is associated with an apparent endothelial dysfunction and impaired endothelium-dependent vasodilatation in response to increased flow and…”
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Effect of YC‐1, an NO‐independent, superoxide‐sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators by Mülsch, Alexander, Bauersachs, Johann, Schäfer, Andreas, Stasch, Johannes‐Peter, Kast, Raimund, Busse, Rudi

“…1 We studied the effects of 3‐(5′‐hydroxymethyl‐2′furyl)‐1‐benzyl indazole (YC‐1) on the activity of purified soluble guanylyl cyclase (sGC), the formation of…”
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Subcellular localization and characterization of nitric oxide synthase(s) in endothelial cells : physiological implications by HECKER, M, MÜLSCH, A, BASSENGE, E, FÖRSTERMANN, U, BUSSE, R

“…Endothelial cells (EC) contain a constitutive Ca2+/calmodulin-dependent nitric oxide (NO) synthase (cNOS) which plays an important role in the local control of…”
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Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin by Busse, Rudi, Mülsch, Alexander

“…We investigated whether calmodulin mediates the stimulating effect of Ca 2+ on nitric oxide synthase in the cytosol of porcine aortic endothelial cells. Nitric…”
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NG-nitro-L-arginine (N5-[imino(nitroamino)methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine by MÜLSCH, A, BUSSE, R

“…We studied the effects of the L-arginine analogue NG-nitro-arginine (L-NNA), in comparison with its D-isomer [D-NNA), on endothelium-dependent dilations of…”
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Increased Nitrovasodilator Sensitivity in Endothelial Nitric Oxide Synthase Knockout Mice: Role of Soluble Guanylyl Cyclase by Brandes, Ralf P, Kim, Do-yei, Schmitz-Winnenthal, Friedrich-Hubertus, Amidi, Mojgan, Gödecke, Axel, Mülsch, Alexander, Busse, Rudi

“…ABSTRACTEndogenously produced nitric oxide (NO) modulates nitrovasodilator-induced relaxation. We investigated the underlying mechanism in wild-type (WT) mice…”
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Subcellular localization and characterization of neuronal nitric oxide synthase by Hecker, M, Mülsch, A, Busse, R

“…In contrast to the predominantly particulate, Ca2+/calmodulin-dependent nitric oxide (NO) synthase in endothelial cells, the corresponding neuronal isoenzyme…”
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S-Nitrosation of Serum Albumin by Dinitrosyl-Iron Complex by Boese, M, Mordvintcev, P I, Vanin, A F, Busse, R, Mülsch, A

“…The objective of this study was to identify a potential mechanism for S -nitrosation of proteins. Therefore, we assessed S -nitrosation of bovine serum albumin…”
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Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor by GALLE, J, MUÊLSH, A, BUSSE, R, BASSENGE, E

“…The influence of native (N-) and oxidized (Ox-) low density lipoproteins (LDLs) on endothelium-dependent vasomotion is still controversial. We investigated the…”
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Stimulation of Soluble Guanylate Cyclase by an Acetylcholine-Induced Endothelium-Derived Factor from Rabbit and Canine Arteries by Förstermann, Ulrich, Mülsch, Alexander, Böhme, Eycke, Busse, Rudi

“…The present study was designed to investigate the hypothesis that, during acetylcholine-induced endothelium-dependent relaxation, a factors) is released from…”
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Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase by Olesen, Søren‐Peter, Drejer, Jørgen, Axelsson, Oskar, Moldt, Peter, Bang, Lone, Nielsen‐Kudsk, Jens Erik, Busse, Rudi, Mülsch, Alexander

“…The haeme‐containing soluble guanylyl cyclase (α1β1‐heterodimer) is a major intracellular receptor and effector for nitric oxide (NO) and carbon monoxide (CO)…”
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Nitric oxide promotes seizure activity in kainate-treated rats by Mülsch, A, Busse, R, Mordvintcev, P I, Vanin, A F, Nielsen, E O, Scheel-Krüger, J, Olesen, S P

“…L-Arginine-derived nitrogen monoxide (NO) formation was determined in different regions of the rat brain during kainate-induced seizures. NO was trapped in…”
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LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase by Mülsch, A, Busse, R, Liebau, S, Förstermann, U

“…LY 83583 (6-anilino-5,8-quinolinedione) has been reported to lower intracellular cyclic GMP by an unknown mechanism. The objective of the present study was to…”
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