Search Results - "MÜLLER, Udo"

Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT) by Bauer, Christina, Göbel, Klaus, Nagaraj, Nagarjuna, Colantuoni, Christian, Wang, Mengxi, Müller, Udo, Kremmer, Elisabeth, Rottach, Andrea, Leonhardt, Heinrich

“…TET proteins oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine and thus provide a possible means for active DNA…”
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TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation by Müller, Udo, Bauer, Christina, Siegl, Michael, Rottach, Andrea, Leonhardt, Heinrich

“…The discovery of hydroxymethyl-, formyl- and carboxylcytosine, generated through oxidation of methylcytosine by TET dioxygenases, raised the question how these…”
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Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA by Pfaffeneder, Toni, Spada, Fabio, Wagner, Mirko, Brandmayr, Caterina, Laube, Silvia K, Eisen, David, Truss, Matthias, Steinbacher, Jessica, Hackner, Benjamin, Kotljarova, Olga, Schuermann, David, Michalakis, Stylianos, Kosmatchev, Olesea, Schiesser, Stefan, Steigenberger, Barbara, Raddaoui, Nada, Kashiwazaki, Gengo, Müller, Udo, Spruijt, Cornelia G, Vermeulen, Michiel, Leonhardt, Heinrich, Schär, Primo, Müller, Markus, Carell, Thomas

“…5-hydroxymethyluracil (hmU) is an oxidative DNA lesion and a potential intermediate in DNA repair–coupled DNA demethylation pathways. Isotopic labeling and MS…”
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The metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets by Steiner, Normann, Müller, Udo, Hajek, Roman, Sevcikova, Sabina, Borjan, Bojana, Jöhrer, Karin, Göbel, Georg, Pircher, Andreas, Gunsilius, Eberhard

“…Multiple myeloma (MM), a malignant plasma cell disorder, is still an incurable disease. Thus, the identification of novel therapeutic targets is of utmost…”
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Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle by Michel, Miriam, Dubowy, Karl-Otto, Entenmann, Andreas, Karall, Daniela, Adam, Mark Gordian, Zlamy, Manuela, Odri Komazec, Irena, Geiger, Ralf, Niederwanger, Christian, Salvador, Christina, Müller, Udo, Laser, Kai Thorsten, Scholl-Bürgi, Sabine

“…Growing interest lies in the assessment of the metabolic status of patients with a univentricular circulation after Fontan operation, especially in changes of…”
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Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise by Ludwig, Anne K, Zhang, Peng, Hastert, Florian D, Meyer, Stephanie, Rausch, Cathia, Herce, Henry D, Müller, Udo, Lehmkuhl, Anne, Hellmann, Ines, Trummer, Carina, Storm, Christian, Leonhardt, Heinrich, Cardoso, M Cristina

“…Aberrant DNA methylation is a hallmark of various human disorders, indicating that the spatial and temporal regulation of methylation readers and modifiers is…”
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Targeted metabolomic analysis of serum phospholipid and acylcarnitine in the adult Fontan patient with a dominant left ventricle by Michel, Miriam, Dubowy, Karl-Otto, Zlamy, Manuela, Karall, Daniela, Adam, Mark Gordian, Entenmann, Andreas, Keller, Markus Andreas, Koch, Jakob, Odri Komazec, Irena, Geiger, Ralf, Salvador, Christina, Niederwanger, Christian, Müller, Udo, Scholl-Bürgi, Sabine, Laser, Kai Thorsten

“…Background: Patients with a Fontan circulation have altered cholesterol and lipoprotein values. We analysed small organic molecules in extended phopsholipid…”
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Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis by Dahlhoff, Maik, Fröhlich, Thomas, Arnold, Georg J., Müller, Udo, Leonhardt, Heinrich, Zouboulis, Christos C., Schneider, Marlon R.

“…Lipid metabolism depends on lipid droplets (LD), cytoplasmic structures surrounded by a protein-rich phospholipid monolayer. Although lipid synthesis is the…”
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Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease by Ambrosini, Yoko M., Neuber, Sebastian, Borcherding, Dana, Seo, Yeon-Jung, Segarra, Sergi, Glanemann, Barbara, Garden, Oliver A., Müller, Udo, Adam, M. Gordian, Dang, Viet, Borts, David, Atherly, Todd, Willette, Auriel A., Jergens, Albert, Mochel, Jonathan P., Allenspach, Karin

“…Canine inflammatory bowel disease (IBD) is a chronic, immunologically mediated intestinal disorder, resulting from the complex interaction of genetic,…”
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Burnout and effort-reward-imbalance in a sample of 949 German teachers by UNTERBRINK, Thomas, HACK, Anna, BAUER, Joachim, PFEIFER, Ruth, BUHL-GRIEBHABER, Veronika, MÜLLER, Udo, WESCHE, Helmut, FROMMHOLD, Markus, SCHEUCH, Klaus, SEIBT, Reingard, WIRSCHING, Michael

“…High rates of teachers' premature retirement initiated a research investigating their occupational burden. The aim of this study was to elaborate on and extend…”
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Working conditions, adverse events and mental health problems in a sample of 949 German teachers by BAUER, Joachim, UNTERBRINK, Thomas, WIRSCHING, Michael, HACK, Anna, PFEIFER, Ruth, BUHL-GRIESSHABER, Veronika, MÜLLER, Udo, WESCHE, Helmut, FROMMHOLD, Markus, SEIBT, Reingard, SCHEUCH, Klaus

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Chemotherapy-associated treatment burden in breast cancer patients receiving lipegfilgrastim or pegfilgrastim: secondary efficacy data from a phase III study by Gladkov, Oleg A., Buchner, Anton, Bias, Peter, Müller, Udo, Elsässer, Reiner

“…Purpose Lipegfilgrastim is a once-per-cycle glycoPEGylated granulocyte colony-stimulating factor (G-CSF). Noninferiority of lipegfilgrastim versus…”
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Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives by Spruijt, Cornelia G., Gnerlich, Felix, Smits, Arne H., Pfaffeneder, Toni, Jansen, Pascal W.T.C., Bauer, Christina, Münzel, Martin, Wagner, Mirko, Müller, Markus, Khan, Fariha, Eberl, H. Christian, Mensinga, Anneloes, Brinkman, Arie B., Lephikov, Konstantin, Müller, Udo, Walter, Jörn, Boelens, Rolf, van Ingen, Hugo, Leonhardt, Heinrich, Carell, Thomas, Vermeulen, Michiel

“…Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these…”
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Efficacy and safety of lipegfilgrastim compared with placebo in patients with non-small cell lung cancer receiving chemotherapy: post hoc analysis of elderly versus younger patients by Volovat, Constantin, Bondarenko, Igor, Gladkov, Oleg, Buchner, Anton, Lammerich, Andreas, Müller, Udo, Bias, Peter

“…Purpose Lipegfilgrastim, a glycoPEGylated recombinant granulocyte colony-stimulating factor (G-CSF), reduces neutropenia duration and febrile neutropenia (FN)…”
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Evaluation Of Electrocardiogram Parameters In Patients With Breast and Lung Cancer Treated With Chemotherapy and Lipegfilgrastim Or Pegfilgrastim by Lammerich, Andreas, Bondarenko, Igor, Müller, Udo

“…Chemotherapy (CTx) may cause adverse events such as neutropenia, febrile neutropenia (FN), and cardiotoxicity. Lipegfilgrastim is a once-per-cycle, fixed-dose,…”
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Prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia with lipegfilgrastim in 2489 cancer patients: final results from the non-interventional study NADIR by Fietz, Thomas, Lück, Andreas, Schulz, Holger, Harde, Johanna, Losem, Christoph, Grebhardt, Sina, Wolff, Thomas, Potthoff, Karin, Müller, Udo, Zaiss, Matthias, Kurbacher, Christian Martin

“…Objectives: The non-interventional study (NIS) NADIR (DRKS00005711) evaluated the effectiveness and safety of prophylaxis with lipegfilgrastim, a…”
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Lipegfilgrastim: pharmacodynamics and pharmacokinetics for body-weight-adjusted and 6 mg fixed doses in two randomized studies in healthy volunteers by Buchner, Anton, Lammerich, Andreas, Abdolzade-Bavil, Afsaneh, Müller, Udo, Bias, Peter

“…Abstract Objective: Two phase I, single-blind (subject blinded to treatment), randomized studies were conducted to assess the pharmacodynamics,…”
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Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia by Spathopoulou, Angeliki, Sauerwein, Gabriella A., Marteau, Valentin, Podlesnic, Martina, Lindlbauer, Theresa, Kipura, Tobias, Hotze, Madlen, Gabassi, Elisa, Kruszewski, Katharina, Koskuvi, Marja, Réthelyi, János M., Apáti, Ágota, Conti, Luciano, Ku, Manching, Koal, Therese, Müller, Udo, Talmazan, Radu A., Ojansuu, Ilkka, Vaurio, Olli, Lähteenvuo, Markku, Lehtonen, Šárka, Mertens, Jerome, Kwiatkowski, Marcel, Günther, Katharina, Tiihonen, Jari, Koistinaho, Jari, Trajanoski, Zlatko, Edenhofer, Frank

“…Schizophrenia (SCZ) is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. The etiology behind the disorder remains…”
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Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins by Heim, Astrid, Grimm, Christina, Müller, Udo, Häußler, Simon, Mackeen, Mukram M, Merl, Juliane, Hauck, Stefanie M, Kessler, Benedikt M, Schofield, Christopher J, Wolf, Alexander, Böttger, Angelika

“…The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown to hydroxylate lysine residues in the essential splice factor U2 auxiliary factor 65 kDa…”
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EGFR/ERBB receptors differentially modulate sebaceous lipogenesis by Dahlhoff, Maik, Camera, Emanuela, Ludovici, Matteo, Picardo, Mauro, Müller, Udo, Leonhardt, Heinrich, Zouboulis, Christos C., Schneider, Marlon R.

“…•EGFR, ERBB2 and ERBB3 tyrosine kinase receptors are expressed in human sebocytes.•Expression of EGFR/ERBBs is downregulated during sebaceous…”
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