Search Results - "MÜLLER, Christoph W"

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression by Kalb, Reinhard, Latwiel, Sebastian, Baymaz, H Irem, Jansen, Pascal W T C, Müller, Christoph W, Vermeulen, Michiel, Müller, Jürg

“…PRC2 promotes methylation of H3K27, a modification that recruits PRC1, which in turn deposits H2A ubiquitin marks. Müller and colleagues use biochemistry…”
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The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage by Jeske, Mandy, Müller, Christoph W, Ephrussi, Anne

“…DEAD-box RNA helicases play important roles in a wide range of metabolic processes. Regulatory proteins can stimulate or block the activity of DEAD-box…”
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Cooperative binding of two acetylation marks on a histone tail by a single bromodomain by Sadoul, Karin, Hart, Darren J, Soler-López, Montserrat, Vitte, Anne-Laure, Govin, Jérôme, Gaucher, Jonathan, Müller, Christoph W, Morinière, Jeanne, Rousseaux, Sophie, Petosa, Carlo, Steuerwald, Ulrich, Khochbin, Saadi, Curtet, Sandrine, Krijgsveld, Jeroen

“…A key step in many chromatin-related processes is the recognition of histone post-translational modifications by effector modules such as bromodomains and…”
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In-cell architecture of the nuclear pore and snapshots of its turnover by Allegretti, Matteo, Zimmerli, Christian E., Rantos, Vasileios, Wilfling, Florian, Ronchi, Paolo, Fung, Herman K. H., Lee, Chia-Wei, Hagen, Wim, Turoňová, Beata, Karius, Kai, Börmel, Mandy, Zhang, Xiaojie, Müller, Christoph W., Schwab, Yannick, Mahamid, Julia, Pfander, Boris, Kosinski, Jan, Beck, Martin

“…Nuclear pore complexes (NPCs) fuse the inner and outer membranes of the nuclear envelope. They comprise hundreds of nucleoporins (Nups) that assemble into…”
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Structural insight into the DNMT1 reaction cycle by cryo-electron microscopy by De, Inessa, Weidenhausen, Jonas, Concha, Nestor, Müller, Christoph W

“…DNMT1 is an essential DNA methyltransferase that catalyzes the transfer of methyl groups to CpG islands in DNA and generates a prominent epigenetic mark. The…”
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Crystal structure of the 14-subunit RNA polymerase I by Fernández-Tornero, Carlos, Moreno-Morcillo, María, Rashid, Umar J., Taylor, Nicholas M. I., Ruiz, Federico M., Gruene, Tim, Legrand, Pierre, Steuerwald, Ulrich, Müller, Christoph W.

“…Protein biosynthesis depends on the availability of ribosomes, which in turn relies on ribosomal RNA production. In eukaryotes, this process is carried out by…”
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Pervasive Protein Thermal Stability Variation during the Cell Cycle by Becher, Isabelle, Andrés-Pons, Amparo, Romanov, Natalie, Stein, Frank, Schramm, Maike, Baudin, Florence, Helm, Dominic, Kurzawa, Nils, Mateus, André, Mackmull, Marie-Therese, Typas, Athanasios, Müller, Christoph W., Bork, Peer, Beck, Martin, Savitski, Mikhail M.

“…Quantitative mass spectrometry has established proteome-wide regulation of protein abundance and post-translational modifications in various biological…”
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Molecular structures of unbound and transcribing RNA polymerase III by Hoffmann, Niklas A., Jakobi, Arjen J., Moreno-Morcillo, María, Glatt, Sebastian, Kosinski, Jan, Hagen, Wim J. H., Sachse, Carsten, Müller, Christoph W.

“…RNA polymerase III (Pol III), the largest eukaryote polymerase yet characterized, transcribes structured small non-coding RNAs; here cryo-electron microscopy…”
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The signalling conformation of the insulin receptor ectodomain by Weis, Felix, Menting, John G., Margetts, Mai B., Chan, Shu Jin, Xu, Yibin, Tennagels, Norbert, Wohlfart, Paulus, Langer, Thomas, Müller, Christoph W., Dreyer, Matthias K., Lawrence, Michael C.

“…Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes…”
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Molecular mechanism of promoter opening by RNA polymerase III by Vorländer, Matthias K., Khatter, Heena, Wetzel, Rene, Hagen, Wim J. H., Müller, Christoph W.

“…RNA polymerase III (Pol III) and transcription factor IIIB (TFIIIB) assemble together on different promoter types to initiate the transcription of small,…”
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Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis by Luna-Zurita, Luis, Stirnimann, Christian U., Glatt, Sebastian, Kaynak, Bogac L., Thomas, Sean, Baudin, Florence, Samee, Md Abul Hassan, He, Daniel, Small, Eric M., Mileikovsky, Maria, Nagy, Andras, Holloway, Alisha K., Pollard, Katherine S., Müller, Christoph W., Bruneau, Benoit G.

“…Transcription factors (TFs) are thought to function with partners to achieve specificity and precise quantitative outputs. In the developing heart, heterotypic…”
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A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT by Miller, Thomas C. R., Simon, Bernd, Rybin, Vladimir, Grötsch, Helga, Curtet, Sandrine, Khochbin, Saadi, Carlomagno, Teresa, Müller, Christoph W.

“…Bromodomains are critical components of many chromatin modifying/remodelling proteins and are emerging therapeutic targets, yet how they interact with…”
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The Crystal Structure of the Drosophila Germline Inducer Oskar Identifies Two Domains with Distinct Vasa Helicase- and RNA-Binding Activities by Jeske, Mandy, Bordi, Matteo, Glatt, Sebastian, Müller, Sandra, Rybin, Vladimir, Müller, Christoph W., Ephrussi, Anne

“…In many animals, the germ plasm segregates germline from soma during early development. Oskar protein is known for its ability to induce germ plasm formation…”
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Cryo-EM structures of human RNA polymerase I by Misiaszek, Agata D., Girbig, Mathias, Grötsch, Helga, Baudin, Florence, Murciano, Brice, Lafita, Aleix, Müller, Christoph W.

“…RNA polymerase I (Pol I) specifically synthesizes ribosomal RNA. Pol I upregulation is linked to cancer, while mutations in the Pol I machinery lead to…”
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Molecular insight into RNA polymerase I promoter recognition and promoter melting by Sadian, Yashar, Baudin, Florence, Tafur, Lucas, Murciano, Brice, Wetzel, Rene, Weis, Felix, Müller, Christoph W.

“…RNA polymerase I (Pol I) assembles with core factor (CF) and Rrn3 on the rDNA core promoter for transcription initiation. Here, we report cryo-EM structures of…”
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Genetically encoded multimeric tags for subcellular protein localization in cryo-EM by Fung, Herman K. H., Hayashi, Yuki, Salo, Veijo T., Babenko, Anastasiia, Zagoriy, Ievgeniia, Brunner, Andreas, Ellenberg, Jan, Müller, Christoph W., Cuylen-Haering, Sara, Mahamid, Julia

“…Cryo-electron tomography (cryo-ET) allows for label-free high-resolution imaging of macromolecular assemblies in their native cellular context. However, the…”
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Architecture of the yeast Elongator complex by Dauden, Maria I, Kosinski, Jan, Kolaj‐Robin, Olga, Desfosses, Ambroise, Ori, Alessandro, Faux, Celine, Hoffmann, Niklas A, Onuma, Osita F, Breunig, Karin D, Beck, Martin, Sachse, Carsten, Séraphin, Bertrand, Glatt, Sebastian, Müller, Christoph W

“…The highly conserved eukaryotic Elongator complex performs specific chemical modifications on wobble base uridines of tRNAs, which are essential for proteome…”
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Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi by Glatt, Sebastian, Zabel, Rene, Kolaj-Robin, Olga, Onuma, Osita F, Baudin, Florence, Graziadei, Andrea, Taverniti, Valerio, Lin, Ting-Yu, Baymann, Frauke, Séraphin, Bertrand, Breunig, Karin D, Müller, Christoph W

“…The eukaryotic Elongator complex participates in modification of uridines in tRNAs. Structural and functional work on a bacterial Elp3, the catalytic subunit…”
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Structural insights into transcription initiation by yeast RNA polymerase I by Sadian, Yashar, Tafur, Lucas, Kosinski, Jan, Jakobi, Arjen J, Wetzel, Rene, Buczak, Katarzyna, Hagen, Wim JH, Beck, Martin, Sachse, Carsten, Müller, Christoph W

“…In eukaryotic cells, RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA (pre‐rRNA) that is subsequently processed into mature rRNA. To initiate…”
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Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation by Vorländer, Matthias K., Jungblut, Anna, Karius, Kai, Baudin, Florence, Grötsch, Helga, Kosinski, Jan, Müller, Christoph W.

“…Transcription factor (TF) IIIC is a conserved eukaryotic six-subunit protein complex with dual function. It serves as a general TF for most RNA polymerase…”
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