Search Results - "MØLLER, Jesper Vuust"

Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components by Lindner, Paula, Christensen, Søren Brøgger, Nissen, Poul, Møller, Jesper Vuust, Engedal, Nikolai

“…Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling…”
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The structural basis of calcium transport by the calcium pump by Møller, Jesper Vuust, Gyrup, Claus, Picard, Martin, Nissen, Poul, Olesen, Claus, Winther, Anne-Marie Lund, Morth, J. Preben, Oxvig, Claus

“…The sarcoplasmic reticulum Ca2+-ATPase, a P-type ATPase, has a critical role in muscle function and metabolism. Here we present functional studies and three…”
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Ion Pathways in the Sarcoplasmic Reticulum Ca2+-ATPase by Bublitz, Maike, Musgaard, Maria, Poulsen, Hanne, Thøgersen, Lea, Olesen, Claus, Schiøtt, Birgit, Morth, J.Preben, Møller, Jesper Vuust, Nissen, Poul

“…The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is a transmembrane ion transporter belonging to the PII-type ATPase family. It performs the vital task of…”
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Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes by Sonntag, Yonathan, Musgaard, Maria, Olesen, Claus, Schiøtt, Birgit, Møller, Jesper Vuust, Nissen, Poul, Thøgersen, Lea

“…The structural elucidation of membrane proteins continues to gather pace, but we know little about their molecular interactions with the lipid environment or…”
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Phosphoryl Transfer and Calcium Ion Occlusion in the Calcium Pump by Sørensen, Thomas Lykke-Møller, Møller, Jesper Vuust, Nissen, Poul

“…A tight coupling between adenosine triphosphate (ATP) hydrolysis and vectorial ion transport has to be maintained by ATP-consuming ion pumps. We report two…”
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SERCA mutant E309Q binds two Ca2+ ions but adopts a catalytically incompetent conformation by Clausen, Johannes D, Bublitz, Maike, Arnou, Bertrand, Montigny, Cédric, Jaxel, Christine, Møller, Jesper Vuust, Nissen, Poul, Andersen, Jens Peter, le Maire, Marc

“…The sarco(endo)plasmic reticulum Ca 2+ ‐ATPase (SERCA) couples ATP hydrolysis to transport of Ca 2+ . This directed energy transfer requires cross‐talk between…”
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Dephosphorylation of the Calcium Pump Coupled to Counterion Occlusion by Olesen, Claus, Sørensen, Thomas Lykke-Møller, Nielsen, Rikke Christina, Møller, Jesper Vuust, Nissen, Poul

“…P-type ATPases extract energy by hydrolysis of adenosine triphosphate (ATP) in two steps, formation and breakdown of a covalent phosphoenzyme intermediate…”
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Modulatory and catalytic modes of ATP binding by the calcium pump by Jensen, Anne-Marie Lund, Sørensen, Thomas Lykke-Møller, Olesen, Claus, Møller, Jesper Vuust, Nissen, Poul

“…We present crystal structures of the calcium‐free E2 state of the sarcoplasmic reticulum Ca2+‐ATPase, stabilized by the inhibitor thapsigargin and the ATP…”
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Cyclopiazonic Acid Is Complexed to a Divalent Metal Ion When Bound to the Sarcoplasmic Reticulum Ca2+-ATPase by Laursen, Mette, Bublitz, Maike, Moncoq, Karine, Olesen, Claus, Møller, Jesper Vuust, Young, Howard S., Nissen, Poul, Morth, J. Preben

“…We have determined the structure of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) in an E2·Pi-like form stabilized as a complex with MgF42−, an ATP…”
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Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase by Skytte, Dorthe Mondrup, Møller, Jesper Vuust, Liu, Huizhen, Nielsen, Helle Østergren, Svenningsen, Louise Elsa, Jensen, Christina Mernøe, Olsen, Carl Erik, Christensen, Søren Brøgger

“…Removal of each of the acyl groups of thapsigargin at O-3, O-8 and O-10 significant reduces the affinity of the inhibitors to the SERCA1a pump. Replacement of…”
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Ca2+ versus Mg2+ coordination at the nucleotide-binding site of the sarcoplasmic reticulum Ca2+-ATPase by Picard, Martin, Jensen, Anne-Marie Lund, Sørensen, Thomas L-M, Champeil, Philippe, Møller, Jesper Vuust, Nissen, Poul

“…The recently determined crystal structure of the sarcoplasmic reticulum Ca2+-ATPase (SERCA1a) with a bound ATP analogue (AMPPCP) reveals a compact state,…”
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Crystal Structure of the Vanadate-Inhibited Ca2+-ATPase by Clausen, Johannes D., Bublitz, Maike, Arnou, Bertrand, Olesen, Claus, Andersen, Jens Peter, Møller, Jesper Vuust, Nissen, Poul

“…Vanadate is the hallmark inhibitor of the P-type ATPase family; however, structural details of its inhibitory mechanism have remained unresolved. We have…”
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Targeting thapsigargin towards tumors by Doan, Nhu Thi Quynh, Paulsen, Eleonora Sandholdt, Sehgal, Pankaj, Møller, Jesper Vuust, Nissen, Poul, Denmeade, Samuel R., Isaacs, John T., Dionne, Craig A., Christensen, Søren Brøgger

“…•We review isolation and structural elucidation of thapsigargin.•We review medicinal chemistry of thapsigargin.•We review the effect of thapsigargin on the…”
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Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a) by Chen, Jialin, De Raeymaecker, Joren, Hovgaard, Jannik Brøndsted, Smaardijk, Susanne, Vandecaetsbeek, Ilse, Wuytack, Frank, Møller, Jesper Vuust, Eggermont, Jan, De Maeyer, Marc, Christensen, Søren Brøgger, Vangheluwe, Peter

“…The Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a) is implicated in breast cancer and Hailey-Hailey disease. Here, we purified recombinant human…”
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S-Palmitoylation and S-Oleoylation of Rabbit and Pig Sarcolipin by Montigny, Cédric, Decottignies, Paulette, Le Maréchal, Pierre, Capy, Pierre, Bublitz, Maike, Olesen, Claus, Møller, Jesper Vuust, Nissen, Poul, le Maire, Marc

“…Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by…”
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Membrane‐protein crystals for neutron diffraction by Sørensen, Thomas Lykke-Møller, Hjorth-Jensen, Samuel John, Oksanen, Esko, Andersen, Jacob Lauwring, Olesen, Claus, Møller, Jesper Vuust, Nissen, Poul

“…Neutron macromolecular crystallography (NMX) has the potential to provide the experimental input to address unresolved aspects of transport mechanisms and…”
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Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L expressed in Xenopus laevis oocytes by David-Bosne, Stéphanie, Clausen, Michael Voldsgaard, Poulsen, Hanne, Møller, Jesper Vuust, Nissen, Poul, le Maire, Marc

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Erratum: Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L expressed in Xenopus laevis oocytes by David-Bosne, Stéphanie, Clausen, Michael Voldsgaard, Poulsen, Hanne, Møller, Jesper Vuust, Nissen, Poul, le Maire, Marc

“…Nat. Struct. Mol. Biol. 23, 1–2 (2016); published online 6 January 2016; corrected after print 13 January 2016 In the version of this article initially…”
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Characterization of a Listeria monocytogenes Ca²⁺ Pump: A SERCA-TYPE ATPase WITH ONLY ONE Ca²⁺-BINDING SITE by Faxén, Kristina, Andersen, Jacob Lauwring, Gourdon, Pontus, Fedosova, Natalya, Morth, Jens Preben, Nissen, Poul, Møller, Jesper Vuust

“…We have characterized a putative Ca²⁺-ATPase from the pathogenic bacterium Listeria monocytogenes with the locus tag lmo0841. The purified and…”
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HiLiDeSystematic Approach to Membrane Protein Crystallization in Lipid and Detergent by Gourdon, Pontus, Andersen, Jacob Lauwring, Hein, Kim Langmach, Bublitz, Maike, Pedersen, Bjørn Panyella, Liu, Xiang-Yu, Yatime, Laure, Nyblom, Maria, Nielsen, Thorbjørn Terndrup, Olesen, Claus, Møller, Jesper Vuust, Nissen, Poul, Morth, Jens Preben

“…To obtain the initial crystallization hit and the subsequent optimization remain the major bottlenecks in membrane protein structure determination. Here we…”
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