Search Results - "MÄKINEN, MARKUS"

Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance by Tuomisto, Anne E, Mäkinen, Markus J, Väyrynen, Juha P

“…Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40% of colorectal cancer patients. The hallmarks of systemic…”
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Characteristics and significance of colorectal cancer associated lymphoid reaction by Väyrynen, Juha P., Sajanti, Sara A., Klintrup, Kai, Mäkelä, Jyrki, Herzig, Karl‐Heinz, Karttunen, Tuomo J., Tuomisto, Anne, Mäkinen, Markus J.

“…A subset of colorectal cancers (CRCs) exhibits so‐called Crohn's like lymphoid reaction (CLR), an inflammatory reaction pattern that consists of numerous…”
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Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer by Sirniö, Päivi, Väyrynen, Juha P., Klintrup, Kai, Mäkelä, Jyrki, Mäkinen, Markus J., Karttunen, Tuomo J., Tuomisto, Anne

“…Recent studies have reported of an association between high serum apolipoprotein A1 (APOA1) levels and favorable prognosis in several malignancies, while the…”
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Pituitary Adenoma Predisposition Caused by Germline Mutations in the AIP Gene by Vierimaa, Outi, Georgitsi, Marianthi, Lehtonen, Rainer, Vahteristo, Pia, Kokko, Antti, Raitila, Anniina, Tuppurainen, Karoliina, Ebeling, Tapani M.L, Salmela, Pasi I, Paschke, Ralf, Gündogdu, Sadi, De Menis, Ernesto, Mäkinen, Markus J, Launonen, Virpi, Karhu, Auli, Aaltonen, Lauri A

“…Pituitary adenomas are common in the general population, and understanding their molecular basis is of great interest. Combining chip-based technologies with…”
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Endostatin Overexpression Inhibits Lymphangiogenesis and Lymph Node Metastasis in Mice by BRIDEAU, Gaëlle, MÄKINEN, Markus J, ELAMAA, Harri, HONGMIN TU, NILSSON, Gunnar, ALITALO, Kari, PIHLAJANIEMI, Taina, HELJASVAARA, Ritva

“…Endostatin, a proteolytic fragment of collagen XVIII, is a potent inhibitor of angiogenesis and tumor growth. We studied the development of carcinogen-induced…”
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Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer by Elomaa, Hanna, Ahtiainen, Maarit, Väyrynen, Sara A., Ogino, Shuji, Nowak, Jonathan A., Friman, Marjukka, Helminen, Olli, Wirta, Erkki-Ville, Seppälä, Toni T., Böhm, Jan, Mäkinen, Markus J., Mecklin, Jukka-Pekka, Kuopio, Teijo, Väyrynen, Juha P.

“…Background Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells…”
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The relationships between serum cytokine levels and tumor infiltrating immune cells and their clinical significance in colorectal cancer by Väyrynen, Juha P., Kantola, Tiina, Väyrynen, Sara A., Klintrup, Kai, Bloigu, Risto, Karhu, Toni, Mäkelä, Jyrki, Herzig, Karl‐Heinz, Karttunen, Tuomo J., Tuomisto, Anne, Mäkinen, Markus J.

“…Increased inflammatory cell infiltration correlates to improved survival in colorectal cancer (CRC). Development and progression of CRC is associated with…”
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Immunohistochemical Glucagon-like Peptide-1 Receptor Expression in Human Insulinomas by Vesterinen, Tiina, Peltola, Elina, Leijon, Helena, Hannula, Päivi, Huhtala, Heini, Mäkinen, Markus J, Nieminen, Lasse, Pirinen, Elina, Rönty, Mikko, Söderström, Mirva, Jaatinen, Pia, Arola, Johanna

“…Insulinomas are rare functional pancreatic neuroendocrine tumours, which metastasize in 10% of cases. As predicting the prognosis can be challenging, there is…”
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Prognostic and predictive role of tumour-associated macrophages in HER2 positive breast cancer by Honkanen, Tiia J., Tikkanen, Antti, Karihtala, Peeter, Mäkinen, Markus, Väyrynen, Juha P., Koivunen, Jussi P.

“…Disease outcomes of HER2+ breast cancers have dramatically improved after targeted therapies, such as trastuzumab became available. The main mechanism of…”
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Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma by Stefanius, Karoliina, Ylitalo, Laura, Tuomisto, Anne, Kuivila, Rami, Kantola, Tiina, Sirniö, Päivi, Karttunen, Tuomo J, Mäkinen, Markus J

“…Stefanius K, Ylitalo L, Tuomisto A, Kuivila R, Kantola T, Sirniö P, Karttunen T J & Mäkinen M J
(2011) Histopathology58, 679–692
Frequent mutations of KRAS in…”
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Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancer by Kastinen, Meeri, Sirniö, Päivi, Elomaa, Hanna, Äijälä, Ville K, Karjalainen, Henna, Tapiainen, Vilja V, Pohjanen, Vesa-Matti, Kemppainen, Janette, Sliashynskaya, Katja, Ahtiainen, Maarit, Rintala, Jukka, Meriläinen, Sanna, Rautio, Tero, Saarnio, Juha, Mattila, Taneli T, Lindgren, Outi, Wirta, Erkki-Ville, Helminen, Olli, Seppälä, Toni T, Böhm, Jan, Mecklin, Jukka-Pekka, Tuomisto, Anne, Mäkinen, Markus J, Väyrynen, Juha P

“…Tumor necrosis has been reported to represent an independent prognostic factor in colorectal cancer, but its evaluation methods have not been described in…”
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Divergent expression of bacterial wall sensing Toll-like receptors 2 and 4 in colorectal cancer by Paarnio, Karoliina, Väyrynen, Sara, Klintrup, Kai, Ohtonen, Pasi, Mäkinen, Markus J, Mäkelä, Jyrki, Karttunen, Tuomo J

“…To characterize the expression of toll-like receptors (TLR) 2 and 4 in colorectal cancer (CRC) and in normal colorectal mucosa. We analysed tissue samples from…”
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Regulatory mechanisms of T cell activation—From basic research discoveries to a new principle of cancer therapy and the Nobel Prize by Väyrynen, Juha P., Tuomisto, Anne, Mäkinen, Markus J.

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Immunological and prognostic significance of tumour necrosis in colorectal cancer by Kastinen, Meeri, Sirniö, Päivi, Elomaa, Hanna, Ahtiainen, Maarit, Väyrynen, Sara A., Herzig, Karl-Heinz, Meriläinen, Sanna, Aro, Raila, Häivälä, Reetta, Rautio, Tero, Saarnio, Juha, Wirta, Erkki-Ville, Helminen, Olli, Seppälä, Toni T., Kuopio, Teijo, Böhm, Jan, Tuomisto, Anne, Mecklin, Jukka-Pekka, Mäkinen, Markus J., Väyrynen, Juha P.

“…Background Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and…”
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Seasonal Regulation of Metabolism: The Effect of Wintertime Fasting and Autumnal Fattening on Key Central Regulators of Metabolism and the Metabolic Profile of the Raccoon Dog (Nyctereutes Procyonoides) by Niiranen, Laura, Mäkelä, Kari A., Dona, Anthony, Krumsiek, Jan, Karhu, Toni, Mäkinen, Markus J., Thalmann, Olaf, Saarela, Seppo, Herzig, Karl-Heinz

“…Investigations into the mechanisms regulating obesity are frantic and novel translational approaches are needed. The raccoon dog (Nyctereutes procyonoides) is…”
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Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts by Osterlund, Emerik, Ristimäki, Ari, Mäkinen, Markus J., Kytölä, Soili, Kononen, Juha, Pfeiffer, Per, Soveri, Leena‐Maija, Keinänen, Mauri, Sorbye, Halfdan, Nunes, Luís, Salminen, Tapio, Nieminen, Lasse, Uutela, Aki, Halonen, Päivi, Ålgars, Annika, Sundström, Jari, Kallio, Raija, Ristamäki, Raija, Lamminmäki, Annamarja, Stedt, Hanna, Heervä, Eetu, Kuopio, Teijo, Sjöblom, Tobias, Isoniemi, Helena, Glimelius, Bengt, Osterlund, Pia

“…BRAF‐V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non‐V600Emt, designated atypical…”
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High Familial Risk in Nodular Lymphocyte-Predominant Hodgkin Lymphoma by SAARINEN, Silva, PUKKALA, Eero, VAHTERISTO, Pia, MÄKINEN, Markus J, FRANSSILA, Kaarle, AALTONEN, Lauri A

“…Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is one of the two established Hodgkin lymphoma (HL) subtypes. The risk factors of NLPHL are largely…”
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Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells by Moilanen, Jyri M., Löffek, Stefanie, Kokkonen, Nina, Salo, Sirpa, Väyrynen, Juha P., Hurskainen, Tiina, Manninen, Aki, Riihilä, Pilvi, Heljasvaara, Ritva, Franzke, Claus-Werner, Kähäri, Veli-Matti, Salo, Tuula, Mäkinen, Markus J., Tasanen, Kaisa

“…Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are…”
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Ectopic crypt foci in conventional and serrated colorectal polyps by Väyrynen, Sara A, Väyrynen, Juha P, Klintrup, Kai, Mäkelä, Jyrki, Tuomisto, Anne, Mäkinen, Markus J

“…Despite almost pathognomonic status of ectopic crypt foci (ECF) in the diagnosis of traditional serrated adenoma (TSA), there are few systematic studies on…”
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KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells by Patankar, Madhura, Eskelinen, Sinikka, Tuomisto, Anne, Mäkinen, Markus J, Karttunen, Tuomo J

“…In a number of types of cancer, anoikis, a form of apoptosis induced by loss of extracellular matrix (ECM) attachment, is disturbed. Anoikis resistance is…”
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