Role of CD44 in nonpalpable T1a and T1b breast cancer

Role of CD44 in nonpalpable T1a and T1b breast cancer

Primary infiltrating ductal carcinomas (IDCs) of the breast which measure less than 0.5 cm (T1a lesions) and between 0.5 and 1.0 cm (T1b lesions) are associated with a small risk of nodal metastasis. The role of axillary dissection in T1a and T1b breast cancer is controversial. In the absence of axi...

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Bibliographic Details
Published in:Human pathology Vol. 28; no. 7; pp. 772 - 778
Main Authors: Lyzak, J.S, Yaremko, M.L, Recant, W, Baunoch, D.A, Joseph, L
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-07-1997
Elsevier
Subjects:
adhesion molecule
Antigens, Neoplasm - metabolism
Biological and medical sciences
breast neoplasm
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
CD44
Female
Gynecology. Andrology. Obstetrics
Humans
Hyaluronan Receptors - metabolism
Immunohistochemistry
Lymphatic Metastasis
Mammary gland diseases
Medical sciences
metastases
Prognosis
Reference Values
T1b
Tla
Tumors
metastases
T1b
DAB
adhesion molecule
breast neoplasm
Tla
IDC
ER
CD44
Human
Immunohistochemistry
Ductal carcinoma
Prognosis
Lymph node
Cell adhesion molecule
Malignant tumor
Metastasis
Adhesion
Invasion
Pathology
Mammary gland diseases
Clinical stage
Mammary gland
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Summary:Primary infiltrating ductal carcinomas (IDCs) of the breast which measure less than 0.5 cm (T1a lesions) and between 0.5 and 1.0 cm (T1b lesions) are associated with a small risk of nodal metastasis. The role of axillary dissection in T1a and T1b breast cancer is controversial. In the absence of axillary dissection, comparable prognostic information might be obtained by examination of the primary cancer. The adhesion molecule CD44 represents a family of transmembrane proteins that mediate cell-cell and cell-matrix interactions. Previous investigators have correlated expression of CD44 and its isoforms with prognosis in breast cancer. We investigated the value of CD44 isoform expression as a predictor of nodal metastases in nonpalpable T1a and T1b IDC. Monoclonal antibody against the standard form of CD44 (CD44s) and polyclonal antibody directed against the variant isoform (CD44v6) was tested on 34 cases of nonpalpable node-negative infiltrating ductal carcinoma (IDC) less than 1.0 cm and 9 cases of nonpalpable node-positive IDC less than 1.0 cm. The expression of CD44s was significantly decreased in node-positive Tla and T1b IDC versus node-negative T1a and T1b IDC (11% vs 65%). In contrast, 97% of the node-negative IDC and 100% of the node-positive IDC expressed the CD44v6 isoform. We conclude that CD44s expression is significantly altered in T1a and T1b IDC with nodal metastases but that the CD44v6 isoform does not correlate with nodal metastases in nonpalpable stage T1a and T1b IDC.
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ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(97)90148-9