Correlation of psychomotor retardation with plasma G-CSF and M-CSF levels in patients with major depressive disorder

BackgroundThe etiopathogenesis of major depressive disorder (MDD) is strongly associated with neuroinflammation. MDD is a highly heterogeneous psychiatric disorder, and the disease subtyping is an essential step for the identification of biological markers. The presence of psychomotor retardation se...

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Bibliographic Details
Published in:	Sichuan Jingshen Weisheng Vol. 36; no. 6; pp. 485 - 490
Main Authors:	Geng Yanhong, Wang Meiti, Liu Fengju, Xu, Yi, Wang Chongze, Fan Xiaohe, Lyv, Qinyu, Ma, Weiliang, Wu, Hong
Format:	Journal Article
Language:	Chinese
Published:	Chengdu Editorial Office of Sichuan Mental Health 01-12-2023
Subjects:	cytokines granulocyte colony-stimulating factor macrophage colony-stimulating factor major depressive disorder Mental depression Mental disorders Mental health Plasma psychomotor retardation
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Summary:	BackgroundThe etiopathogenesis of major depressive disorder (MDD) is strongly associated with neuroinflammation. MDD is a highly heterogeneous psychiatric disorder, and the disease subtyping is an essential step for the identification of biological markers. The presence of psychomotor retardation seriously affects the prognosis of MDD, whereas the underlying mechanism is not yet completely clear. A potential involvement of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) in the pathogenesis of MDD with psychomotor retardation has been suggested in previous studies, but little detailed research has been completed.ObjectiveTo analyze the correlation of plasma G-CSF and M-CSF levels with psychomotor retardation in patients with MDD, and to explore the potential biological underpinnings of psychomotor retardation in MDD. MethodsA total of 50 MDD patients who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5)
ISSN:	1007-3256
DOI:	10.11886/scjsws20230219002