Search Results - "Lyukmanova, Ekaterina"

Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins by Zaigraev, Maxim M, Lyukmanova, Ekaterina N, Paramonov, Alexander S, Shenkarev, Zakhar O, Chugunov, Anton O

“…Ly6/uPAR proteins regulate many essential functions in the nervous and immune systems and epithelium. Most of these proteins contain single β-structural LU…”
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Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor by Lyukmanova, Ekaterina N, Shulepko, Mikhail A, Kudryavtsev, Denis, Bychkov, Maxim L, Kulbatskii, Dmitrii S, Kasheverov, Igor E, Astapova, Maria V, Feofanov, Alexey V, Thomsen, Morten S, Mikkelsen, Jens D, Shenkarev, Zakhar O, Tsetlin, Victor I, Dolgikh, Dmitry A, Kirpichnikov, Mikhail P

“…SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the…”
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Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors by Bychkov, Maxim, Shenkarev, Zakhar, Shulepko, Mikhail, Shlepova, Olga, Kirpichnikov, Mikhail, Lyukmanova, Ekaterina

“…Lynx1 is the first three-finger prototoxin found in the mammalian central nervous system. It is a GPI-anchored protein modulating nicotinic acetylcholine…”
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Caloric restriction triggers morphofunctional remodeling of astrocytes and enhances synaptic plasticity in the mouse hippocampus by Popov, Alexander, Denisov, Pavel, Bychkov, Maxim, Brazhe, Alexey, Lyukmanova, Ekaterina, Shenkarev, Zakhar, Lazareva, Natalia, Verkhratsky, Alexei, Semyanov, Alexey

“…Calorie-restricted (CR) diet has multiple beneficial effects on brain function. Here we report morphological and functional changes in hippocampal astrocytes…”
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Aβ1-42 Accumulation Accompanies Changed Expression of Ly6/uPAR Proteins, Dysregulation of the Cholinergic System, and Degeneration of Astrocytes in the Cerebellum of Mouse Model of Early Alzheimer Disease by Bychkov, Maxim L, Isaev, Aizek B, Andreev-Andrievskiy, Alexander A, Petrov, Konstantin, Paramonov, Alexander S, Kirpichnikov, Mikhail P, Lyukmanova, Ekaterina N

“…Alzheimer disease (AD) is a widespread neurodegenerative disease characterized by the accumulation of oligomeric toxic forms of β-amyloid (Aβ1-42) and…”
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Mitochondrial malfunction and atrophy of astrocytes in the aged human cerebral cortex by Popov, Alexander, Brazhe, Nadezda, Morozova, Kseniia, Yashin, Konstantin, Bychkov, Maxim, Nosova, Olga, Sutyagina, Oksana, Brazhe, Alexey, Parshina, Evgenia, Li, Li, Medyanik, Igor, Korzhevskii, Dmitry E., Shenkarev, Zakhar, Lyukmanova, Ekaterina, Verkhratsky, Alexei, Semyanov, Alexey

“…How aging affects cells of the human brain active milieu remains largely unknown. Here, we analyze astrocytes and neurons in the neocortical tissue of younger…”
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Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells by Shulepko, Mikhail A., Bychkov, Maxim L., Shlepova, Olga V., Shenkarev, Zakhar O., Kirpichnikov, Mikhail P., Lyukmanova, Ekaterina N.

“…•Three-finger proteins from the Ly6/uPAR family inhibit cancer cell proliferation.•SLURP-1 selectively inhibits the growth of cancer cells.•Human protein…”
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Spatial structure and oligomerization of viscotoxin A3 in detergent micelles: Implication for mechanisms of ion channel formation and membrane lysis by Paramonov, Alexander S., Lyukmanova, Ekaterina N., Tonevitsky, Alexander G., Arseniev, Alexander S., Shenkarev, Zakhar O.

“…Thionins are the family of small (∼5 kDa) cationic cysteine-rich peptides involved in the immune response in plants. Viscotoxin A3 (VtA3) is the thionin from…”
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Structural and Functional Characterization of Alternative Transmembrane Domain Conformations in VEGF Receptor 2 Activation by Manni, Sandro, Mineev, Konstantin S., Usmanova, Dinara, Lyukmanova, Ekaterina N., Shulepko, Mikhail A., Kirpichnikov, Mikhail P., Winter, Jonas, Matkovic, Milos, Deupi, Xavier, Arseniev, Alexander S., Ballmer-Hofer, Kurt

“…Transmembrane signaling by receptor tyrosine kinases (RTKs) entails ligand-mediated dimerization and structural rearrangement of the extracellular domains. RTK…”
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Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider Phoneutria nigriventer by Lyukmanova, Ekaterina N, Mironov, Pavel A, Kulbatskii, Dmitrii S, Shulepko, Mikhail A, Paramonov, Alexander S, Chernaya, Elizaveta M, Logashina, Yulia A, Andreev, Yaroslav A, Kirpichnikov, Mikhail P, Shenkarev, Zakhar O

“…Phα1β (PnTx3-6) is a neurotoxin from the spider venom, originally identified as an antagonist of two ion channels involved in nociception: N-type voltage-gated…”
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Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein by Sluchanko, Nikolai N., Kapitonova, Anna A., Shulepko, Mikhail A., Kukushkin, Ilya D., Kulbatskii, Dmitrii S., Tugaeva, Kristina V., Varfolomeeva, Larisa A., Minyaev, Mikhail E., Boyko, Konstantin M., Popov, Vladimir O., Kirpichnikov, Mikhail P., Lyukmanova, Ekaterina N.

“…Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels composed of five homologous subunits. The homopentameric α7-nAChR, abundantly…”
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Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis by Shulepko, Mikhail A., Bychkov, Maxim L., Shenkarev, Zakhar O., Kulbatskii, Dmitrii S., Makhonin, Alexey M., Paramonov, Alexander S., Chugunov, Anton O., Kirpichnikov, Mikhail P., Lyukmanova, Ekaterina N.

“…Mal de Meleda is an autosomal recessive palmoplantar keratoderma associated with mutations in a gene encoding SLURP-1. SLURP-1 controls growth,…”
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Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors by Paramonov, Alexander S, Kocharovskaya, Milita V, Tsarev, Andrey V, Kulbatskii, Dmitrii S, Loktyushov, Eugene V, Shulepko, Mikhail A, Kirpichnikov, Mikhail P, Lyukmanova, Ekaterina N, Shenkarev, Zakhar O

“…Ly-6/uPAR or three-finger proteins (TFPs) contain a disulfide-stabilized β-structural core and three protruding loops (fingers). In mammals, TFPs have been…”
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Water‐soluble variant of human Lynx1 positively modulates synaptic plasticity and ameliorates cognitive impairment associated with α7‐nAChR dysfunction by Shenkarev, Zakhar O., Shulepko, Mikhail A., Bychkov, Maxim L., Kulbatskii, Dmitrii S., Shlepova, Olga V., Vasilyeva, Nathalia A., Andreev-Andrievskiy, Alexander A., Popova, Anfisa S., Lagereva, Evgeniya A., Loktyushov, Eugene V., Koshelev, Sergey G., Thomsen, Morten S., Dolgikh, Dmitry A., Kozlov, Sergey A., Balaban, Pavel M., Kirpichnikov, Mikhail P., Lyukmanova, Ekaterina N.

“…Lynx1 is a GPI‐tethered protein colocalized with nicotinic acetylcholine receptors (nAChRs) in the brain areas important for learning and memory. Previously,…”
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Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells by Lyukmanova, Ekaterina N, Zaigraev, Maxim M, Kulbatskii, Dmitrii S, Isaev, Aizek B, Kukushkin, Ilya D, Bychkov, Maxim L, Shulepko, Mikhail A, Chugunov, Anton O, Kirpichnikov, Mikhail P

“…Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion…”
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Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels by Osmakov, Dmitry I, Khasanov, Timur A, Andreev, Yaroslav A, Lyukmanova, Ekaterina N, Kozlov, Sergey A

“…Acid-sensing ion channels (ASICs) are of the most sensitive molecular sensors of extracellular pH change in mammals. Six isoforms of these channels are widely…”
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New Three-Finger Protein from Starfish Asteria rubens Shares Structure and Pharmacology with Human Brain Neuromodulator Lynx2 by Paramonov, Alexander S., Shulepko, Mikhail A., Makhonin, Alexey M., Bychkov, Maxim L., Kulbatskii, Dmitrii S., Chernikov, Andrey M., Myshkin, Mikhail Yu, Shabelnikov, Sergey V., Shenkarev, Zakhar O., Kirpichnikov, Mikhail P., Lyukmanova, Ekaterina N.

“…Three-finger proteins (TFPs) are small proteins with characteristic three-finger β-structural fold stabilized by the system of conserved disulfide bonds. These…”
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Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer by Sudarikova, Anastasia V., Bychkov, Maxim L., Kulbatskii, Dmitrii S., Chubinskiy-Nadezhdin, Vladislav I., Shlepova, Olga V., Shulepko, Mikhail A., Koshelev, Sergey G., Kirpichnikov, Mikhail P., Lyukmanova, Ekaterina N.

“…Lung cancer is one of the most common cancer types in the world. Despite existing treatment strategies, overall patient survival remains low and new targeted…”
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NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1 by Lyukmanova, Ekaterina N., Shenkarev, Zakhar O., Shulepko, Mikhail A., Mineev, Konstantin S., D'Hoedt, Dieter, Kasheverov, Igor E., Filkin, Sergey Yu, Krivolapova, Alexandra P., Janickova, Helena, Dolezal, Vladimir, Dolgikh, Dmitry A., Arseniev, Alexander S., Bertrand, Daniel, Tsetlin, Victor I., Kirpichnikov, Mikhail P.

“…Discovery of proteins expressed in the central nervous system sharing the three-finger structure with snake α-neurotoxins provoked much interest to their role…”
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Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors by Kudryavtsev, Denis S., Shelukhina, Irina V., Son, Lina V., Ojomoko, Lucy O., Kryukova, Elena V., Lyukmanova, Ekaterina N., Zhmak, Maxim N., Dolgikh, Dmitry A., Ivanov, Igor A., Kasheverov, Igor E., Starkov, Vladislav G., Ramerstorfer, Joachim, Sieghart, Werner, Tsetlin, Victor I., Utkin, Yuri N.

“…Ionotropic receptors of γ-aminobutyric acid (GABAAR) regulate neuronal inhibition and are targeted by benzodiazepines and general anesthetics. We show that a…”
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