Search Results - "Lyubchenko, Yuri"

Protein Self-Assembly at the Liquid–Surface Interface. Surface-Mediated Aggregation Catalysis by Lyubchenko, Yuri L.

“…Protein self-assembly into aggregates of various morphologies is a ubiquitous phenomenon in physical chemistry and biophysics. The critical role of amyloid…”
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Nanoscale Structure, Interactions, and Dynamics of Centromere Nucleosomes by Filliaux, Shaun, Sun, Zhiqiang, Lyubchenko, Yuri L.

“…Centromeres are specific segments of chromosomes comprising two types of nucleosomes: canonical nucleosomes containing an octamer of H2A, H2B, H3, and H4…”
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Free Cholesterol Accelerates Aβ Self-Assembly on Membranes at Physiological Concentration by Hashemi, Mohtadin, Banerjee, Siddhartha, Lyubchenko, Yuri L

“…The effects of membranes on the early-stage aggregation of amyloid β (Aβ) have come to light as potential mechanisms by which neurotoxic species are formed in…”
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Amyloid cascade hypothesis for Alzheimer’s disease. Does it work under physiological conditions? by Lyubchenko, Yuri

“…<img src=” https://s3.amazonaws.com/production.scholastica/article/77826/large/prnano_942023_toc_figure.jpg?1686262046”> Plaques in the brain consisting of…”
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Topographically smooth and stable supported lipid bilayer for high-resolution AFM studies by Banerjee, Siddhartha, Lyubchenko, Yuri L.

“…•Supported lipid bilayer serves as effective model membrane system for topograhic AFM studies.•Smooth, homogeneous, trapped vesicle free lipid bilayer is…”
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Hybrid resolution molecular dynamics simulations of amyloid proteins interacting with membranes by Hashemi, Mohtadin, Lyubchenko, Yuri L.

“…•Hybrid resolution molecular dynamics simulation method is described.•Hybrid resolution molecular dynamics simulations allow characterization of interactions…”
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The Sequence Dependent Nanoscale Structure of CENP-A Nucleosomes by Stormberg, Tommy, Lyubchenko, Yuri L.

“…CENP-A is a histone variant found in high abundance at the centromere in humans. At the centromere, this histone variant replaces the histone H3 found…”
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Dynamics of Nucleosomes Assessed with Time-Lapse High-Speed Atomic Force Microscopy by Miyagi, Atsushi, Ando, Toshio, Lyubchenko, Yuri L

“…A fundamental challenge of gene regulation is the accessibility of DNA within nucleosomes. Recent studies performed by various techniques, including…”
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Force clamp approach for characterization of nano-assembly in amyloid beta 42 dimer by Maity, Sibaprasad, Lyubchenko, Yuri L

“…Amyloid β (Aβ) oligomers are formed at the early stages of the amyloidogenesis process and exhibit neurotoxicity. Development of oligomer specific therapeutics…”
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Nanoscale Dynamics of Amyloid β‑42 Oligomers As Revealed by High-Speed Atomic Force Microscopy by Banerjee, Siddhartha, Sun, Zhiqiang, Hayden, Eric Y, Teplow, David B, Lyubchenko, Yuri L

“…Amyloid β-protein (Aβ) oligomers are emerging as potent neurotoxic species in Alzheimer’s disease pathogenesis. Detailed characterization of oligomer structure…”
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Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer by Carmicheal, Joseph, Hayashi, Chihiro, Huang, Xi, Liu, Lei, Lu, Yao, Krasnoslobodtsev, Alexey, Lushnikov, Alexander, Kshirsagar, Prakash G., Patel, Asish, Jain, Maneesh, Lyubchenko, Yuri L., Lu, Yongfeng, Batra, Surinder K., Kaur, Sukhwinder

“…Pancreatic cancer is a highly lethal malignancy. Lack of early diagnostic markers makes timely detection of pancreatic cancer a highly challenging endeavor…”
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Atomic force microscopy–based characterization of the interaction of PriA helicase with stalled DNA replication forks by Wang, Yaqing, Sun, Zhiqiang, Bianco, Piero R., Lyubchenko, Yuri L.

“…In bacteria, the restart of stalled DNA replication forks requires the DNA helicase PriA. PriA can recognize and remodel abandoned DNA replication forks,…”
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SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity by Seamon, Kyle J, Sun, Zhiqiang, Shlyakhtenko, Luda S, Lyubchenko, Yuri L, Stivers, James T

“…The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to…”
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Cholesterol in Membranes Facilitates Aggregation of Amyloid β Protein at Physiologically Relevant Concentrations by Banerjee, Siddhartha, Hashemi, Mohtadin, Zagorski, Karen, Lyubchenko, Yuri L

“…The formation of amyloid β (1-42) (Aβ42) oligomers is considered to be a critical step in the development of Alzheimer’s disease (AD). However, the mechanism…”
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Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers by Banerjee, Siddhartha, Hashemi, Mohtadin, Zagorski, Karen, Lyubchenko, Yuri L

“…The self-assembly of amyloid β (Aβ) proteins into oligomers is the major pathogenic event leading to Alzheimer's disease (AD). Typical in vitro experiments…”
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Site-Search Process for Synaptic Protein-DNA Complexes by Vemulapalli, Sridhar, Hashemi, Mohtadin, Lyubchenko, Yuri L

“…The assembly of synaptic protein-DNA complexes by specialized proteins is critical for bringing together two distant sites within a DNA molecule or bridging…”
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Preparation of DNA and nucleoprotein samples for AFM imaging by Lyubchenko, Yuri L.

“…Sample preparation techniques allowing reliable and reproducible imaging of DNA with various structures, topologies and complexes with proteins are reviewed…”
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DNA Looping Mediated by Site-Specific SfiI–DNA Interactions by Vemulapalli, Sridhar, Hashemi, Mohtadin, Kolomeisky, Anatoly B, Lyubchenko, Yuri L

“…Interactions between distant DNA segments play important roles in various biological processes, such as DNA recombination. Certain restriction enzymes create…”
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The Structure of Misfolded Amyloidogenic Dimers: Computational Analysis of Force Spectroscopy Data by Zhang, Yuliang, Lyubchenko, Yuri L.

“…Progress in understanding the molecular mechanism of self-assembly of amyloidogenic proteins and peptides requires knowledge about their structure in misfolded…”
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Nano-assembly of amyloid β peptide: role of the hairpin fold by Maity, Sibaprasad, Hashemi, Mohtadin, Lyubchenko, Yuri L.

“…Structural investigations have revealed that β hairpin structures are common features in amyloid fibrils, suggesting that these motifs play an important role…”
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