Search Results - "Lyu, Meinan"

A ‘Build and Retrieve’ methodology to simultaneously solve cryo-EM structures of membrane proteins by Su, Chih-Chia, Lyu, Meinan, Morgan, Christopher E., Bolla, Jani Reddy, Robinson, Carol V., Yu, Edward W.

“…Single-particle cryo-electron microscopy (cryo-EM) has become a powerful technique in the field of structural biology. However, the inability to reliably…”
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Cryo-EM structures of the human band 3 transporter indicate a transport mechanism involving the coupled movement of chloride and bicarbonate ions by Su, Chih-Chia, Zhang, Zhemin, Lyu, Meinan, Cui, Meng, Yu, Edward W

“…The band 3 transporter is a critical integral membrane protein of the red blood cell (RBC), as it is responsible for catalyzing the exchange of bicarbonate and…”
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Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport by Su, Chih-Chia, Klenotic, Philip A, Cui, Meng, Lyu, Meinan, Morgan, Christopher E, Yu, Edward W

“…The mycobacterial membrane protein large 3 (MmpL3) transporter is essential and required for shuttling the lipid trehalose monomycolate (TMM), a precursor of…”
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Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance by Lyu, Meinan, Moseng, Mitchell A, Reimche, Jennifer L, Holley, Concerta L, Dhulipala, Vijaya, Su, Chih-Chia, Shafer, William M, Yu, Edward W

“…is an obligate human pathogen and causative agent of the sexually transmitted infection (STI) gonorrhea. The most predominant and clinically important…”
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High-resolution structural-omics of human liver enzymes by Su, Chih-Chia, Lyu, Meinan, Zhang, Zhemin, Miyagi, Masaru, Huang, Wei, Taylor, Derek J., Yu, Edward W.

“…We applied raw human liver microsome lysate to a holey carbon grid and used cryo-electron microscopy (cryo-EM) to define its composition. From this sample we…”
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Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export by Moseng, Mitchell A, Lyu, Meinan, Pipatpolkai, Tanadet, Glaza, Przemyslaw, Emerson, Corey C, Stewart, Phoebe L, Stansfeld, Phillip J, Yu, Edward W

“…Gram-negative bacteria utilize the resistance-nodulation-cell division (RND) superfamily of efflux pumps to expel a variety of toxic compounds from the cell…”
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Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump by Lyu, Meinan, Ayala, Julio C, Chirakos, Isabella, Su, Chih-Chia, Shafer, William M, Yu, Edward W

“…Bacterial efflux pumps in the resistance-nodulation-cell division (RND) family of Gram-negative bacteria contribute significantly to the development of…”
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Elucidating the Structural Dynamics of Integrin α IIbβ 3 from Native Platelet Membranes By Cryo-EM Coupled with Build and Retrieve Data Processing Methodology by Han, Xu, Su, Chih-Chia, Zhang, Zhemin, Lyu, Meinan, Yu, Edward, Nieman, Marvin T.

“…Background: Platelets play a critical role in physiological processes by sensing the extracellular environment through their membrane proteins. Changing the…”
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Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT by Lyu, Meinan, Su, Chih-Chia, Kazura, James W, Yu, Edward W

“…The intra-erythrocyte stage of P. falciparum relies primarily on glycolysis to generate adenosine triphosphate (ATP) and the energy required to support growth…”
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Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT by Lyu, Meinan, Su, Chih-Chia, Kazura, James W, Yu, Edward W

“…Graphical Abstract…”
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Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT by Lyu, Meinan, Su, Chih-Chia, Kazura, James W, Yu, Edward W

“…Graphical Abstract…”
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Simultaneous solving high-resolution structures of various enzymes from human kidney microsomes by Lyu, Meinan, Su, Chih-Chia, Miyagi, Masaru, Yu, Edward W

“…The ability to investigate tissues and organs through an integrated systems biology approach has been thought to be unobtainable in the field of structural…”
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Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling by Moseng, Mitchell A, Su, Chih-Chia, Rios, Kerri, Cui, Meng, Lyu, Meinan, Glaza, Przemyslaw, Klenotic, Philip A, Delpire, Eric, Yu, Edward W

“…The Na-K-2Cl cotransporter-1 (NKCC1) is an electroneutral Na -dependent transporter responsible for simultaneously translocating Na , K , and Cl ions into…”
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