Search Results - "Lyu, Jungmook"

Cleavage of the Wnt Receptor Ryk Regulates Neuronal Differentiation during Cortical Neurogenesis by Lyu, Jungmook, Yamamoto, Vicky, Lu, Wange

“…Ryk is a transmembrane receptor tyrosine kinase (RTK). It functions as a receptor of Wnt proteins required for cell-fate determination, axon guidance, and…”
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Sestrin2 inhibits YAP activation and negatively regulates corneal epithelial cell proliferation by Lee, Ji-Su, Park, Hwan-Woo, Cho, Kyong Jin, Lyu, Jungmook

“…Corneal wound healing is essential for the maintenance of corneal integrity and transparency and involves a series of physiological processes that depend on…”
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Wnt/β-catenin signaling stimulates the self-renewal of conjunctival stem cells and promotes corneal conjunctivalization by Jang, Esther, Jin, Soomin, Cho, Kyong Jin, Kim, Daeseon, Rho, Chang Rae, Lyu, Jungmook

“…Limbal stem cell deficiency causes conjunctivalization characterized by the covering of the corneal surface with conjunctival epithelium. However, the driving…”
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Exosomes from Human iPSC-Derived Retinal Organoids Enhance Corneal Epithelial Wound Healing by Lee, Sihyung, Han, Jungwoo, Yang, Jinyoung, Lyu, Jungmook, Park, Hyosong, Bang, Jihong, Kim, Yeji, Chang, Hunsoo, Park, Taekwann

“…This study investigated the therapeutic effects of exosomes derived from human-induced pluripotent stem cell (hiPSC)-derived retinal organoids (ROs) on corneal…”
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Early Developmental Characteristics and Features of a Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis by Han, Jung Woo, Chang, Hun Soo, Park, Sung Chul, Yang, Jin Young, Kim, Ye Ji, Kim, Jin Ha, Park, Hyo Song, Jeong, Han, Lee, Junwon, Yoon, Chang Ki, Yu, Hyung Gon, Woo, Se Joon, Lyu, Jungmook, Park, Tae Kwann

“…X-linked juvenile retinoschisis (XLRS) is a hereditary retinal degeneration affecting young males caused by mutations in the retinoschisin ( ) gene. We…”
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Recombinant sulfated CCR2 peptide trap reduces retinal degeneration in mice by Jung, Sun-Ah, Jin, Soomin, Chae, Jae-Byoung, Jo, GukHeui, Chung, Hyewon, Lyu, Jungmook, Lee, Joon H.

“…Chemokine receptors are generally sulfated at tyrosine residues of the N-terminal region. Tyrosine sulfation of the C–C chemokine receptor type 2 (CCR2)…”
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Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling by Jeong, Seon-Yeong, Lyu, Jungmook, Kim, Jin-A, Oh, Il-Hoan

“…The importance of modulating the intensity of Wnt signaling has been highlighted in various biological models, but their mechanisms remain unclear. In this…”
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Intravitreal Administration of Retinal Organoids-Derived Exosomes Alleviates Photoreceptor Degeneration in Royal College of Surgeons Rats by Targeting the Mitogen-Activated Protein Kinase Pathway by Han, Jung Woo, Chang, Hun Soo, Yang, Jin Young, Choi, Han Sol, Park, Hyo Song, Jun, Hyoung Oh, Choi, Ji Hye, Paik, Sun-Sook, Chung, Kyung Hwun, Shin, Hee Jeong, Nam, Seungyeon, Son, Ji-Hye, Lee, Si Hyung, Lee, Eun Jung, Seo, Kyoung Yul, Lyu, Jungmook, Kim, Jin Woo, Kim, In-Beom, Park, Tae Kwann

“…Increasing evidence suggests that exosomes are involved in retinal cell degeneration, including their insufficient release; hence, they have become important…”
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Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells by Lyu, Jungmook, Jho, Eek-hoon, Lu, Wange

“…In embryonic stem cells （ESCs）, Wnt-responsive development-related genes are silenced to maintain pluripotency and their expression is activated during…”
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Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK/mTOR/ULK1 signaling pathway by Han, Daewon, Kim, Deokryong, Kim, Haeil, Lee, Jeonga, Lyu, Jungmook, Kim, Jong-Seok, Shin, Jongdae, Kim, Jeong Sig, Kim, Do Kyung, Park, Hwan-Woo

“…Metabolism-associated fatty liver disease (MAFLD) is a global health concern because of its association with obesity, insulin resistance, and other metabolic…”
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Polycystin-1 Enhances Stemmness Potential of Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Jung, Se-Hwa, You, Ji-Eun, Choi, Soon-Won, Kang, Kyung-Sun, Cho, Je-Yeol, Lyu, Jungmook, Kim, Pyung-Hwan

“…Polycystic Kidney Disease (PKD) is a disorder that affects the kidneys and other organs, and its major forms are encoded by polycystin-1 (PC1) and polycystin-2…”
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Sulfated CXCR3 Peptide Trap Use as a Promising Therapeutic Approach for Age-Related Macular Degeneration by Jo, Gukheui, Chae, Jae-Byoung, Jung, Sun-Ah, Lyu, Jungmook, Chung, Hyewon, Lee, Joon H

“…Chemokines have various biological functions and potential roles in the development or progression of neuroinflammatory diseases. However, the specific…”
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Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell‐derived retinal organoids by Lee, Si Hyung, Han, Jung Woo, Yang, Jin Young, Jun, Hyoung Oh, Bang, Ji Hong, Shin, Heejeong, Choi, Ji Hye, Lee, Jongwoo, Madrakhimov, Sanjar Batirovich, Chung, Kyung Hwun, Chang, Hun Soo, Lyu, Jungmook, Park, Tae Kwann

“…Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial and…”
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The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development by Zhong, Jingyang, Kim, Hyoung-Tai, Lyu, Jungmook, Yoshikawa, Kazuaki, Nakafuku, Masato, Lu, Wange

“…GABAergic neurons and oligodendrocytes originate from progenitors within the ventral telencephalon. However, the molecular mechanisms that control neuron-glial…”
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Protein Phosphatase 4 and Smek Complex Negatively Regulate Par3 and Promote Neuronal Differentiation of Neural Stem/Progenitor Cells by Lyu, Jungmook, Kim, Hee-Ryang, Yamamoto, Vicky, Choi, Si Ho, Wei, Zong, Joo, Choun-Ki, Lu, Wange

“…Neural progenitor cells (NPCs) are multipotent cells that can self-renew and differentiate into neurons and glial cells. However, mechanisms that control their…”
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Wnt-7a Up-regulates Matrix Metalloproteinase-12 Expression and Promotes Cell Proliferation in Corneal Epithelial Cells during Wound Healing by Lyu, Jungmook, Joo, Choun-Ki

“…Corneal wound repair involves the rapid coverage of a denuded area by residual epithelial cells. During wound healing, there are different cell behaviors in…”
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Cdc37 Regulates Ryk Signaling by Stabilizing the Cleaved Ryk Intracellular Domain by Lyu, Jungmook, Wesselschmidt, Robin L., Lu, Wange

“…Ryk is a Wnt receptor that plays an important role in neurogenesis, neurite outgrowth, and axon guidance. We have reported that the Ryk receptor is cleaved by…”
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Plant-derived angiogenin fusion protein's cytoprotective effect on trabecular meshwork damage induced by Benzalkonium chloride in mice by Jeong, Jae Hoon, Lee, Soo Jin, Ko, Kisung, Lee, Jeong Hwan, Lyu, Jungmook, Park, Moon Hyang, Kang, Jaeku, Kim, Jae Chan

“…Benzalkonium chloride (BAK), commonly used in glaucoma treatment, is an eye drop preservative with dose-dependent toxicity. Previous studies have observed the…”
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Wnt signaling enhances FGF2-triggered lens fiber cell differentiation by Lyu, Jungmook, Joo, Choun-Ki

“…Wnt signaling is implicated in many developmental processes, including cell fate changes. Several members of the Wnt family, as well as other molecules…”
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Ectopic Expression of Axin Blocks Neuronal Differentiation of Embryonic Carcinoma P19 Cells by Lyu, Jungmook, Costantini, Frank, Jho, Eek-hoon, Joo, Choun-ki

“…Axin regulates Wnt signaling through down-regulation of β-catenin. To test the role of Wnt signaling in neuronal differentiation, embryonal carcinoma P19…”
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