Search Results - "Lyu, Jinrui"
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Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice
Published in Molecular psychiatry (01-08-2021)“…Anorexia nervosa (AN) is an eating disorder observed predominantly in women and girls that is characterized by a low body-mass index, hypophagia, and…”
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Reduction of Postoperative Cognitive Deficits in Aged Mice by Chronic Intermittent Propofol
Published in The FASEB journal (01-05-2022)“…Postoperative cognitive dysfunction (POCD) can increase morbidity and mortality after surgery, especially in the elderly. Current evidence from both…”
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Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction
Published in PNAS nexus (01-05-2023)“…The cellular basis of age-related impairments of hippocampal function is not fully understood. In order to evaluate the role of somatostatin-positive (Sst )…”
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Genetic Ablation of Dentate Hilar Somatostatin-Positive GABAergic Interneurons is Sufficient to Induce Cognitive Impairment
Published in Molecular neurobiology (01-02-2024)“…Aging is often associated with a decline in cognitive function. A reduction in the number of somatostatin-positive (SOM + ) interneurons in the dentate gyrus…”
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An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function
Published in Molecular psychiatry (30-08-2024)“…Glycine is an obligatory co-agonist at excitatory NMDA receptors in the brain, especially in the dentate gyrus, which has been postulated to be crucial for the…”
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