Nucleotide Polymorphism in the Iron Utilization System Gene isdB NEAT Domain Affects Heme-Binding Ability of IsdB Protein in Various Human Strains of Staphylococcus aureus

Nucleotide Polymorphism in the Iron Utilization System Gene isdB NEAT Domain Affects Heme-Binding Ability of IsdB Protein in Various Human Strains of Staphylococcus aureus

Genetic heterogeneity of the isdB gene fragment encoding one of two heme-binding NEAr Transporter (NEAT) domains pfam05031 in different isolates of Staphylococcus aureus from the healthy carriers and the risk group patients (chronic inflammatory infections of the upper respiratory tract and middle e...

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Bibliographic Details
Published in:BioNanoScience Vol. 8; no. 1; pp. 390 - 393
Main Authors: Tyurin, Yuriy Aleksandrovich, Lysovskaya, S. A., Kulikov, S. N., Reshetnikova, I. D., Isaeva, Guzel Shavhatovna, Morzunov, Sergey P.
Format: Journal Article
Language:English
Published: New York Springer US 01-03-2018
Springer Nature B.V
Subjects:
Affinity
Binding sites
Biological and Medical Physics
Biomaterials
Biophysics
Circuits and Systems
Engineering
Gene polymorphism
Heme
Hemoglobin
Inflammation
Middle ear
Mutation
Nanotechnology
Polymorphism
Polystyrene
Polystyrene resins
Respiratory tract
Staphylococcus aureus
Hemoglobin
Affinity
Inflammatory upper respiratory tract infections
isdB gene
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Summary:Genetic heterogeneity of the isdB gene fragment encoding one of two heme-binding NEAr Transporter (NEAT) domains pfam05031 in different isolates of Staphylococcus aureus from the healthy carriers and the risk group patients (chronic inflammatory infections of the upper respiratory tract and middle ear) was investigated. All S. aureus strains included in the current study differed phenotypically from one another by degree of affinity to polystyrene with immobilized human hemoglobin. The isolates that displayed low affinity to hemoglobin were found to have more mutations within the isdB gene fragment which encodes one of the IsdB protein domains containing heme-binding sites.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-018-0501-z