A comparative evaluation of treatment methods for a genital papillomavirus infection in women with different viral genotypes

Such genotypes of human papilloma virus (HPV) as "malignant" (180), "benign" (49) and indeterminate (127) were identified in 356 females by PCR and cytological procedures. The following therapeutic techniques were compared: cryodestruction of the uterine cervix (60), antiviral me...

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Bibliographic Details
Published in:	Voprosy onkologij Vol. 46; no. 3; p. 340
Main Authors:	Mikhaĭlov, I G, Maksimov, S Ia, Novik, V I, Safronnikova, N R, Vishnevskiĭ, A S, Prianishnikov, V A, Lyshev, A A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2000
Subjects:	Acridines - administration & dosage Adjuvants, Immunologic - administration & dosage Antiviral Agents - administration & dosage Combined Modality Therapy Cryosurgery Drug Therapy, Combination Female Genital Diseases, Female - therapy Genital Diseases, Female - virology Genotype Humans Laser Coagulation Papillomaviridae - genetics Papillomaviridae - pathogenicity Papillomavirus Infections - therapy Papillomavirus Infections - virology Polymerase Chain Reaction Thymus Hormones - administration & dosage Tumor Virus Infections - therapy Tumor Virus Infections - virology Vitamin E - administration & dosage
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Summary:	Such genotypes of human papilloma virus (HPV) as "malignant" (180), "benign" (49) and indeterminate (127) were identified in 356 females by PCR and cytological procedures. The following therapeutic techniques were compared: cryodestruction of the uterine cervix (60), antiviral medication (AVM) (19), combination of AVM and cryodestruction (224), and combination of AVM and laser destruction (54). In the "malignant" HPV group, AVM in conjunction with cryo- or laser destruction was significantly more effective than cryodestruction or AVM alone. Both cryodestruction alone and in combination with AVM were more effective in treating "benign" genotypes. Repeat courses showed the same tendency.
ISSN:	0507-3758