Search Results - "Lyons, Scott"

Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases by Pommier, Arnaud, Anaparthy, Naishitha, Memos, Nicoletta, Kelley, Z Larkin, Gouronnec, Alizée, Yan, Ran, Auffray, Cédric, Albrengues, Jean, Egeblad, Mikala, Iacobuzio-Donahue, Christine A, Lyons, Scott K, Fearon, Douglas T

“…The majority of patients with pancreatic ductal adenocarcinoma (PDA) develop metastatic disease after resection of their primary tumor. We found that livers…”
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Ethical Issues Relating to Scientific Discovery in Exercise Science by Navalta, James W, Stone, Whitley J, Lyons, T Scott

“…This work aims to present concepts related to ethical issues in conducting and reporting scientific research in a clear and straightforward manner…”
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Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice by Albrengues, Jean, Shields, Mario A, Ng, David, Park, Chun Gwon, Ambrico, Alexandra, Poindexter, Morgan E, Upadhyay, Priya, Uyeminami, Dale L, Pommier, Arnaud, Küttner, Victoria, Bružas, Emilis, Maiorino, Laura, Bautista, Carmelita, Carmona, Ellese M, Gimotty, Phyllis A, Fearon, Douglas T, Chang, Kenneth, Lyons, Scott K, Pinkerton, Kent E, Trotman, Lloyd C, Goldberg, Michael S, Yeh, Johannes T-H, Egeblad, Mikala

“…Cancer cells from a primary tumor can disseminate to other tissues, remaining dormant and clinically undetectable for many years. Little is known about the…”
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BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network by Sun, Xueqin, Klingbeil, Olaf, Lu, Bin, Wu, Caizhi, Ballon, Carlos, Ouyang, Meng, Wu, Xiaoli S., Jin, Ying, Hwangbo, Yon, Huang, Yu-Han, Somerville, Tim D. D., Chang, Kenneth, Park, Jung, Chung, Taemoon, Lyons, Scott K., Shi, Junwei, Vogel, Hannes, Schulder, Michael, Vakoc, Christopher R., Mills, Alea A.

“…Inhibition of the tumour suppressive function of p53 (encoded by TP53 ) is paramount for cancer development in humans. However, p53 remains unmutated in the…”
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A chemical solution for FRET(ful) pairs by Lyons, Scott N., Cambronne, Xiaolu A.

“…The development of biosensors has been slowed by the optimization required for each new iteration. Now, the ChemoX platform facilitates the expansion of sensor…”
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CRISPR/Cas for PET Reporter Gene Engineering by Chung, Taemoon, Merrill, Joseph R, Lyons, Scott K

“…The relatively recent discovery of CRISPR/Cas has led to a revolution in our ability to efficiently manipulate the genome of eukaryotic cells. We describe here…”
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Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer by Asim, Mohammad, Tarish, Firas, Zecchini, Heather I., Sanjiv, Kumar, Gelali, Eleni, Massie, Charles E., Baridi, Ajoeb, Warren, Anne Y., Zhao, Wanfeng, Ogris, Christoph, McDuffus, Leigh-Anne, Mascalchi, Patrice, Shaw, Greg, Dev, Harveer, Wadhwa, Karan, Wijnhoven, Paul, Forment, Josep V., Lyons, Scott R., Lynch, Andy G., O’Neill, Cormac, Zecchini, Vincent R., Rennie, Paul S., Baniahmad, Aria, Tavaré, Simon, Mills, Ian G., Galanty, Yaron, Crosetto, Nicola, Schultz, Niklas, Neal, David, Helleday, Thomas

“…Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition…”
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The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis by Massie, Charles E, Lynch, Andy, Ramos-Montoya, Antonio, Boren, Joan, Stark, Rory, Fazli, Ladan, Warren, Anne, Scott, Helen, Madhu, Basetti, Sharma, Naomi, Bon, Helene, Zecchini, Vinny, Smith, Donna-Michelle, DeNicola, Gina M, Mathews, Nik, Osborne, Michelle, Hadfield, James, MacArthur, Stewart, Adryan, Boris, Lyons, Scott K, Brindle, Kevin M, Griffiths, John, Gleave, Martin E, Rennie, Paul S, Neal, David E, Mills, Ian G

“…The androgen receptor (AR) is a key regulator of prostate growth and the principal drug target for the treatment of prostate cancer. Previous studies have…”
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Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma by Safaric Tepes, Polona, Segovia, Danilo, Jevtic, Sania, Ramirez, Daniel, Lyons, Scott K., Sordella, Raffaella

“…Mesenchymal chondrosarcoma (MCS) is a high-grade malignancy that represents 2–9% of chondrosarcomas and mostly affects children and young adults. HEY1-NCoA2…”
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A quantitative FastFUCCI assay defines cell cycle dynamics at a single-cell level by Koh, Siang-Boon, Mascalchi, Patrice, Rodriguez, Esther, Lin, Yao, Jodrell, Duncan I, Richards, Frances M, Lyons, Scott K

“…The fluorescence ubiquitination-based cell cycle indicator (FUCCI) is a powerful tool for use in live cells but current FUCCI-based assays have limited…”
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Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer by Lenos, Kristiaan J., Miedema, Daniël M., Lodestijn, Sophie C., Nijman, Lisanne E., van den Bosch, Tom, Romero Ros, Xavier, Lourenço, Filipe C., Lecca, Maria C., van der Heijden, Maartje, van Neerven, Sanne M., van Oort, Anita, Leveille, Nicolas, Adam, Ronja S., de Sousa E Melo, Felipe, Otten, Joy, Veerman, Patrick, Hypolite, Guillaume, Koens, Lianne, Lyons, Scott K., Stassi, Giorgio, Winton, Douglas J., Medema, Jan Paul, Morrissey, Edward, Bijlsma, Maarten F., Vermeulen, Louis

“…Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for expansion and relapse after therapy. Here we report on quantitative analyses…”
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Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment by Hazra, Rasmani, Brine, Lily, Garcia, Libia, Benz, Brian, Chirathivat, Napon, Shen, Michael M., Wilkinson, John Erby, Lyons, Scott K., Spector, David L.

“…The mammalian genome encodes thousands of long non-coding RNAs (lncRNAs), many of which are developmentally regulated and differentially expressed across…”
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Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia by Roberts, Edward W, Deonarine, Andrew, Jones, James O, Denton, Alice E, Feig, Christine, Lyons, Scott K, Espeli, Marion, Kraman, Matthew, McKenna, Brendan, Wells, Richard J B, Zhao, Qi, Caballero, Otavia L, Larder, Rachel, Coll, Anthony P, O'Rahilly, Stephen, Brindle, Kevin M, Teichmann, Sarah A, Tuveson, David A, Fearon, Douglas T

“…Fibroblast activation protein-α (FAP) identifies stromal cells of mesenchymal origin in human cancers and chronic inflammatory lesions. In mouse models of…”
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Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection by Adrover, Jose M, Carrau, Lucia, Daßler-Plenker, Juliane, Bram, Yaron, Chandar, Vasuretha, Houghton, Sean, Redmond, David, Merrill, Joseph R, Shevik, Margaret, tenOever, Benjamin R, Lyons, Scott K, Schwartz, Robert E, Egeblad, Mikala

“…Severe acute lung injury has few treatment options and a high mortality rate. Upon injury, neutrophils infiltrate the lungs and form neutrophil extracellular…”
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Bioluminescent imaging: a critical tool in pre-clinical oncology research by O'Neill, Karen, Lyons, Scott K, Gallagher, William M, Curran, Kathleen M, Byrne, Annette T

“…Bioluminescent imaging (BLI) is a non-invasive imaging modality widely used in the field of pre-clinical oncology research. Imaging of small animal tumour…”
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Microglia either promote or restrain TRAIL-mediated excitotoxicity caused by Aβ1−42 oligomers by Zou, Jian, McNair, Elizabeth, DeCastro, Sagan, Lyons, Scott P., Mordant, Angie, Herring, Laura E., Vetreno, Ryan P., Coleman Jr, Leon G.

“…Alzheimer's disease (AD) features progressive neurodegeneration and microglial activation that results in dementia and cognitive decline. The release of…”
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Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation by Lyons, Scott P., Greiner, Elora C., Cressey, Lauren E., Adamo, Mark E., Kettenbach, Arminja N.

“…The family of Phosphoprotein Phosphatases (PPPs) is responsible for most cellular serine and threonine dephosphorylation. PPPs achieve substrate specificity…”
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Advances in imaging mouse tumour models in vivo by Lyons, Scott K

“…Significant progress has been made recently in the variety of ways that cancer can be non‐invasively imaged in murine tumour models. The development and…”
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Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology by Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit M., Froeling, Fieke E. M., Trotman, Lloyd C., Tuveson, David A., Lyons, Scott K.

“…Imaging defined aspects of functional tumor biology with bioluminescent reporter transgenes is a popular approach in preclinical drug development as it is…”
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Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1 by Luciano, Amelia K., Korobkina, Ekaterina D., Lyons, Scott P., Haley, John A., Fluharty, Shelagh M., Jung, Su Myung, Kettenbach, Arminja N., Guertin, David A.

“…Mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) regulates metabolism, cell proliferation, and cell survival. mTORC2 activity is stimulated by growth…”
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