Search Results - "Lyons, Leslie"

Cats – telomere to telomere and nose to tail by Lyons, Leslie A.

“…Feline genomic medicine can decode human variants of uncertain significance (VUSs). Telomere-to-telomere genome assemblies are feasible for all felid species,…”
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A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism by Buckley, Reuben M, Davis, Brian W, Brashear, Wesley A, Farias, Fabiana H G, Kuroki, Kei, Graves, Tina, Hillier, LaDeana W, Kremitzki, Milinn, Li, Gang, Middleton, Rondo P, Minx, Patrick, Tomlinson, Chad, Lyons, Leslie A, Murphy, William J, Warren, Wesley C

“…The domestic cat (Felis catus) numbers over 94 million in the USA alone, occupies households as a companion animal, and, like humans, suffers from cancer and…”
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Precision medicine in cats-The right biomedical model may not be the mouse by Lyons, Leslie A

“…[...]mice with Pea15-targeted mutations have normal brain size and morphology, contrary to a newly defined neurological model in domestic cats [7,9]…”
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Patterns of allele frequency differences among domestic cat breeds assessed by a 63K SNP array by Alhaddad, Hasan, Abdi, Mona, Lyons, Leslie A

“…Cats are ubiquitous companion animals that have been keenly associated with humans for thousands of years and only recently have been intentionally bred for…”
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Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease by Torres, Jacob A., Kruger, Samantha L., Broderick, Caroline, Amarlkhagva, Tselmeg, Agrawal, Shagun, Dodam, John R., Mrug, Michal, Lyons, Leslie A., Weimbs, Thomas

“…Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD) progression in mouse models, but whether the effect was due to solely…”
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DNA mutations of the cat: The good, the bad and the ugly by Lyons, Leslie A

“…Practical relevance: The health of the cat is a complex interaction between its environment (nurture) and its genetics (nature). Over 70 genetic mutations…”
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Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication by Montague, Michael J., Li, Gang, Gandolfi, Barbara, Khan, Razib, Aken, Bronwen L., Searle, Steven M. J., Minx, Patrick, Hillier, LaDeana W., Koboldt, Daniel C., Davis, Brian W., Driscoll, Carlos A., Barr, Christina S., Blackistone, Kevin, Quilez, Javier, Lorente-Galdos, Belen, Marques-Bonet, Tomas, Alkan, Can, Thomas, Gregg W. C., Hahn, Matthew W., Menotti-Raymond, Marilyn, O'Brien, Stephen J., Wilson, Richard K., Lyons, Leslie A., Murphy, William J., Warren, Wesley C.

“…Significance We present highlights of the first complete domestic cat reference genome, to our knowledge. We provide evolutionary assessments of the feline…”
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It's a Knockout for Cat Allergies? by Lyons, Leslie A

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Precision medicine using whole genome sequencing identifies a novel dystrophin (DMD) variant for X‐linked muscular dystrophy in a cat by Shelton, G. Diane, Tucciarone, Fabrizio, Guo, Ling T., Coghill, Lyndon M., Lyons, Leslie A.

“…Background Muscular dystrophies (MDs) are a large, heterogeneous group of degenerative muscle diseases. X‐linked dystrophin‐deficient MD in cats is the first…”
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Genomic approaches to identify hybrids and estimate admixture times in European wildcat populations by Mattucci, Federica, Galaverni, Marco, Lyons, Leslie A., Alves, Paulo C., Randi, Ettore, Velli, Edoardo, Pagani, Luca, Caniglia, Romolo

“…The survival of indigenous European wildcat ( Felis silvestris silvestris ) populations can be locally threatened by introgressive hybridization with…”
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Precision medicine using whole genome sequencing in a cat identifies a novel COL5A1 variant for classical Ehlers‐Danlos syndrome by McElroy, Abigail, Gray‐Edwards, Heather, Coghill, Lyndon M., Lyons, Leslie A.

“…Background Ehlers‐Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders occurring in both human and veterinary patients…”
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De novo Mutations in Domestic Cat are Consistent with an Effect of Reproductive Longevity on Both the Rate and Spectrum of Mutations by Wang, Richard J, Raveendran, Muthuswamy, Harris, R Alan, Murphy, William J, Lyons, Leslie A, Rogers, Jeffrey, Hahn, Matthew W

“…Abstract The mutation rate is a fundamental evolutionary parameter with direct and appreciable effects on the health and function of individuals. Here, we…”
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Genetic relationships and inbreeding levels among geographically distant populations of Felis catus from Japan and the United States by Matsumoto, Yuki, Ruamrungsri, Napat, Arahori, Minori, Ukawa, Hisashi, Ohashi, Ken, Lyons, Leslie A., Ishihara, Genki

“…Pedigreed cats have traditionally been mated with close relatives, which increases the risks for inbreeding depression and genetic disorders. We evaluated the…”
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Extent of linkage disequilibrium in the domestic cat, Felis silvestris catus, and its breeds by Alhaddad, Hasan, Khan, Razib, Grahn, Robert A, Gandolfi, Barbara, Mullikin, James C, Cole, Shelley A, Gruffydd-Jones, Timothy J, Häggström, Jens, Lohi, Hannes, Longeri, Maria, Lyons, Leslie A

“…Domestic cats have a unique breeding history and can be used as models for human hereditary and infectious diseases. In the current era of genome-wide…”
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Beta-mannosidosis in a domestic cat associated with a missense variant in MANBA by Katz, Martin L, Cook, James, Vite, Charles H, Campbell, Rebecca S, Coghill, Lyndon M, Lyons, Leslie A

“…A 6-month-old cat of unknown ancestry presented for a neurologic evaluation due to progressive motor impairment. Complete physical and neurologic examinations…”
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A chromosome-scale fishing cat reference genome for the evaluation of potential germline risk variants by Carroll, Rachel A., Rice, Edward S., Murphy, William J., Lyons, Leslie A., Thibaud-Nissen, Francoise, Coghill, Lyndon M., Swanson, William F., Terio, Karen A., Boyd, Tyler, Warren, Wesley C.

“…The fishing cat, Prionailurus viverrinus , faces a population decline, increasing the importance of maintaining healthy zoo populations. Unfortunately,…”
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Association of a novel dystrophin (DMD) genetic nonsense variant in a cat with X‐linked muscular dystrophy with a mild clinical course by Muto, Harunobu, Yu, Yoshihiko, Chambers, James K., Coghill, Lyndon M., Nakamura, Yasuharu, Uchida, Kazuyuki, Lyons, Leslie A.

“…X‐linked muscular dystrophy in cats (FXMD) is an uncommon disease, with few reports describing its pathogenic genetic variants. A 9‐year‐old castrated male…”
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Applying genomic data in wildlife monitoring: Development guidelines for genotyping degraded samples with reduced single nucleotide polymorphism panels by Thaden, Alina, Nowak, Carsten, Tiesmeyer, Annika, Reiners, Tobias E., Alves, Paulo C., Lyons, Leslie A., Mattucci, Federica, Randi, Ettore, Cragnolini, Margherita, Galián, José, Hegyeli, Zsolt, Kitchener, Andrew C., Lambinet, Clotilde, Lucas, José M., Mölich, Thomas, Ramos, Luana, Schockert, Vinciane, Cocchiararo, Berardino

“…The genomic era has led to an unprecedented increase in the availability of genome‐wide data for a broad range of taxa. Wildlife management strives to make use…”
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Mapping the genetic basis of diabetes mellitus in the Australian Burmese cat (Felis catus) by Samaha, Georgina, Wade, Claire M., Beatty, Julia, Lyons, Leslie A., Fleeman, Linda M., Haase, Bianca

“…Diabetes mellitus, a common endocrinopathy affecting domestic cats, shares many clinical and pathologic features with type 2 diabetes in humans. In Australia…”
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Precision/Genomic Medicine for Domestic Cats by Buckley, Reuben M, Lyons, Leslie A

“…The era of Precision / Genomic Medicine has arrived and can improve the veterinary healthcare of companion animals. The goal of Precision / Genomic Medicine is…”
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