Search Results - "Lyon, C. C."

Mechanotransduction in cardiac hypertrophy and failure by Lyon, Robert C, Zanella, Fabian, Omens, Jeffrey H, Sheikh, Farah

“…Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load through a process known as mechanotransduction. In the heart, this…”
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Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease by Sheikh, Farah, Lyon, Robert C., Chen, Ju

“…Myosin light chain-2 (MYL2, also called MLC-2) is an ~19kDa sarcomeric protein that belongs to the EF-hand calcium binding protein superfamily and exists as…”
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A Disynaptic Relay from Superior Colliculus to Dorsal Stream Visual Cortex in Macaque Monkey by Lyon, David C., Nassi, Jonathan J., Callaway, Edward M.

“…The superior colliculus (SC) is the first station in a subcortical relay of retinal information to extrastriate visual cortex. Ascending SC projections pass…”
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Projections between visual cortex and pulvinar in the rat by Scholl, Leo R., Foik, Andrzej T., Lyon, David C.

“…The extrageniculate visual pathway, which carries visual information from the retina through the superficial layers of the superior colliculus and the…”
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Conceptualising and navigating bullying in English secondary schools: a figurational analysis of power imbalances in physical education by Green, Matthew J., Mierzwinski, M. F., Haines Lyon, C.

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The impact of COVID-19 on road safety in Canada and the United States by Vanlaar, W.G.M., Woods-Fry, H., Barrett, H., Lyon, C., Brown, S., Wicklund, C., Robertson, R.D.

“…•The impact of COVID-19 on road safety is studied.•We used self-report data on risky road user behaviors, validated with crash data.•We compared results from…”
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Brain-wide reconstruction of inhibitory circuits after traumatic brain injury by Frankowski, Jan C., Tierno, Alexa, Pavani, Shreya, Cao, Quincy, Lyon, David C., Hunt, Robert F.

“…Despite the fundamental importance of understanding the brain’s wiring diagram, our knowledge of how neuronal connectivity is rewired by traumatic brain injury…”
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In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration by Choi, Elliot H., Suh, Susie, Foik, Andrzej T., Leinonen, Henri, Newby, Gregory A., Gao, Xin D., Banskota, Samagya, Hoang, Thanh, Du, Samuel W., Dong, Zhiqian, Raguram, Aditya, Kohli, Sajeev, Blackshaw, Seth, Lyon, David C., Liu, David R., Palczewski, Krzysztof

“…Leber congenital amaurosis (LCA) is the most common cause of inherited retinal degeneration in children. LCA patients with RPE65 mutations show accelerated…”
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Extracellular matrix remodeling in atrial fibrosis: Mechanisms and implications in atrial fibrillation by Pellman, Jason, Lyon, Robert C, Sheikh, Farah

“…Abstract Atrial fibrosis has been strongly associated with the presence of heart diseases/arrhythmias, including congestive heart failure (CHF) and atrial…”
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Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons by Wickersham, Ian R., Lyon, David C., Barnard, Richard J.O., Mori, Takuma, Finke, Stefan, Conzelmann, Karl-Klaus, Young, John A.T., Callaway, Edward M.

“…There has never been a wholesale way of identifying neurons that are monosynaptically connected either to some other cell group or, especially, to a single…”
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Botulinum neurotoxin A is an effective treatment for irritant dermatitis caused by ostomy leaks in patients with retractile stomas by Bhoyrul, B., Ondhia, D., Lyon, C.

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Experimental partitioning of F and Cl between olivine, orthopyroxene and silicate melt at Earth's mantle conditions by Joachim, Bastian, Pawley, Alison, Lyon, Ian C., Marquardt (neé Hartmann), Katharina, Henkel, Torsten, Clay, Patricia L., Ruzié, Lorraine, Burgess, Ray, Ballentine, Christopher J.

“…Halogens have, because of their volatile behavior and incompatibility, the potential to act as key tracers of volatile transport processes within the Earth's…”
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In situ U–Pb dating of 4 billion-year-old carbonates in the martian meteorite Allan Hills 84001 by Tartèse, Romain, Lyon, Ian C.

“…In situ carbonate U–Pb dating studies have proliferated dramatically in recent years. Almost all these studies have targeted relatively young terrestrial…”
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Dissimilatory Fe(III) Reduction Controls on Arsenic Mobilization: A Combined Biogeochemical and NanoSIMS Imaging Approach by Lopez-Adams, Rebeca, Newsome, Laura, Moore, Katie L, Lyon, Ian C, Lloyd, Jonathan R

“…Microbial metabolism plays a key role in controlling the fate of toxic groundwater contaminants, such as arsenic. Dissimilatory metal reduction catalyzed by…”
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Orientation Tuning of the Suppressive Extraclassical Surround Depends on Intrinsic Organization of V1 by Hashemi-Nezhad, Maziar, Lyon, David C.

“…The intrinsic functional architecture of early cortical areas in highly visual mammals is characterized by the presence of domains and pinwheels, with…”
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The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A‐Dependent by Upadhyay, Jaymin, Xie, LiQin, Huang, Lily, Das, Nanditha, Stewart, Rachel C, Lyon, Morgan C, Palmer, Keryn, Rajamani, Saathyaki, Graul, Chris, Lobo, Merryl, Wellman, Tyler J, Soares, Edward J, Silva, Matthew D, Hesterman, Jacob, Wang, Lili, Wen, Xialing, Qian, Xiaobing, Nannuru, Kalyan, Idone, Vincent, Murphy, Andrew J, Economides, Aris N, Hatsell, Sarah J

“…ABSTRACT Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder that is characterized by episodic yet cumulative heterotopic…”
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Tracing Inputs to Inhibitory or Excitatory Neurons of Mouse and Cat Visual Cortex with a Targeted Rabies Virus by Liu, Yong-Jun, Ehrengruber, Markus U., Negwer, Moritz, Shao, Han-Juan, Cetin, Ali H., Lyon, David C.

“…Background: Cortical inhibition plays a critical role in controlling and modulating cortical excitation, and a more detailed understanding of the neuronal…”
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Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease by Sheikh, Farah, Ouyang, Kunfu, Campbell, Stuart G, Lyon, Robert C, Chuang, Joyce, Fitzsimons, Dan, Tangney, Jared, Hidalgo, Carlos G, Chung, Charles S, Cheng, Hongqiang, Dalton, Nancy D, Gu, Yusu, Kasahara, Hideko, Ghassemian, Majid, Omens, Jeffrey H, Peterson, Kirk L, Granzier, Henk L, Moss, Richard L, McCulloch, Andrew D, Chen, Ju

“…Actin-myosin interactions provide the driving force underlying each heartbeat. The current view is that actin-bound regulatory proteins play a dominant role in…”
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Retrospective cross‐sectional pilot study of rifaximin dosing for the prevention of recurrent hepatic encephalopathy by Lyon, Kelsey C, Likar, Eric, Martello, Jay L, Regier, Michael

“…Standard treatment for hepatic encephalopathy (HE) includes medications that reduce ammonia and bacterial translocation in the gut. Rifaximin can be used…”
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Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy by Liang, Yan, Lyon, Robert C, Pellman, Jason, Bradford, William H, Lange, Stephan, Bogomolovas, Julius, Dalton, Nancy D, Gu, Yusu, Bobar, Marcus, Lee, Mong-Hong, Iwakuma, Tomoo, Nigam, Vishal, Asimaki, Angeliki, Scheinman, Melvin, Peterson, Kirk L, Sheikh, Farah

“…Dysregulated protein degradative pathways are increasingly recognized as mediators of human disease. This mechanism may have particular relevance to desmosomal…”
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