Search Results - "Lyon, Aurore"

Machine learning in the electrocardiogram by Mincholé, Ana, PhD, Camps, Julià, MSc, Lyon, Aurore, PhD, Rodríguez, Blanca, PhD

“…AbstractThe electrocardiogram is the most widely used diagnostic tool that records the electrical activity of the heart and, therefore, its use for identifying…”
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Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers by Lyon, Aurore, Ariga, Rina, Mincholé, Ana, Mahmod, Masliza, Ormondroyd, Elizabeth, Laguna, Pablo, de Freitas, Nando, Neubauer, Stefan, Watkins, Hugh, Rodriguez, Blanca

“…Ventricular arrhythmia triggers sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM), yet electrophysiological biomarkers are not used for risk…”
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Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling by van Osta, Nick, Kirkels, Feddo P, van Loon, Tim, Koopsen, Tijmen, Lyon, Aurore, Meiburg, Roel, Huberts, Wouter, Cramer, Maarten J, Delhaas, Tammo, Haugaa, Kristina H, Teske, Arco J, Lumens, Joost

“…Computational models of the cardiovascular system are widely used to simulate cardiac (dys)function. Personalization of such models for patient-specific…”
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In silico Identification of Disrupted Myocardial Calcium Homeostasis as Proarrhythmic Trigger in Arrhythmogenic Cardiomyopathy by Lyon, Aurore, van Opbergen, Chantal J. M., Delmar, Mario, Heijman, Jordi, van Veen, Toon A. B.

“…Background: Patients with arrhythmogenic cardiomyopathy may suffer from lethal ventricular arrhythmias. Arrhythmogenic cardiomyopathy is predominantly…”
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Predicting the neuro‐cardio‐haemodynamic outcomes of sepsis and its pharmacological interventions: Get to the future through numerical equations by Sutanto, Henry, Lyon, Aurore

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Electrophysiological effects of stretch‐activated ion channels: a systematic computational characterization by Buonocunto, Melania, Lyon, Aurore, Delhaas, Tammo, Heijman, Jordi, Lumens, Joost

“…Cardiac electrophysiology and mechanics are strongly interconnected. Their interaction is, among others, mediated by mechano‐electric feedback through…”
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Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies by Sutanto, Henry, Lyon, Aurore, Lumens, Joost, Schotten, Ulrich, Dobrev, Dobromir, Heijman, Jordi

“…Calcium (Ca2+) plays a central role in cardiomyocyte excitation-contraction coupling. To ensure an optimal electrical impulse propagation and cardiac…”
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Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation by Trayanova, Natalia A, Lyon, Aurore, Shade, Julie, Heijman, Jordi

“…The complexity of cardiac electrophysiology, involving dynamic changes in numerous components across multiple spatial (from ion channel to organ) and temporal…”
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Computational techniques for ECG analysis and interpretation in light of their contribution to medical advances by Lyon, Aurore, Mincholé, Ana, Martínez, Juan Pablo, Laguna, Pablo, Rodriguez, Blanca

“…Widely developed for clinical screening, electrocardiogram (ECG) recordings capture the cardiac electrical activity from the body surface. ECG analysis can…”
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Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities by Lyon, Aurore, Bueno-Orovio, Alfonso, Zacur, Ernesto, Ariga, Rina, Grau, Vicente, Neubauer, Stefan, Watkins, Hugh, Rodriguez, Blanca, Mincholé, Ana

“…To identify key structural and electrophysiological features explaining distinct electrocardiogram (ECG) phenotypes in hypertrophic cardiomyopathy (HCM). Human…”
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Translating myosin-binding protein C and titin abnormalities to whole-heart function using a novel calcium-contraction coupling model by Arts, Theo, Lyon, Aurore, Delhaas, Tammo, Kuster, Diederik W.D., van der Velden, Jolanda, Lumens, Joost

“…Mutations in cardiac myosin-binding protein C (cMyBP-C) or titin may respectively lead to hypertrophic (HCM) or dilated (DCM) cardiomyopathies. The mechanisms…”
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Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations by van Osta, Nick, Kirkels, Feddo, Lyon, Aurore, Koopsen, Tijmen, van Loon, Tim, Cramer, Maarten-Jan, Teske, Arco J, Delhaas, Tammo, Lumens, Joost

“…Abstract Aims Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease, characterized by life-threatening ventricular arrhythmias and progressive…”
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Improving long QT syndrome diagnosis by a polynomial-based T-wave morphology characterization by Hermans, Ben J.M., Bennis, Frank C., Vink, Arja S., Koopsen, Tijmen, Lyon, Aurore, Wilde, Arthur A.M., Nuyens, Dieter, Robyns, Tomas, Pison, Laurent, Postema, Pieter G., Delhaas, Tammo

“…Diagnosing long QT syndrome (LQTS) remains challenging because of a considerable overlap in QT interval between patients with LQTS and healthy subjects…”
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Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation by Lyon, Aurore, van Mourik, Manouk, Cruts, Laura, Heijman, Jordi, Bekkers, Sebastiaan C A M, Schotten, Ulrich, Crijns, Harry J G M, Linz, Dominik, Lumens, Joost

“…Abstract Aims The irregular atrial electrical activity during atrial fibrillation (AF) is associated with a variable left ventricular (LV) systolic function…”
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Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model by van Osta, Nick, Lyon, Aurore, Kirkels, Feddo, Koopsen, Tijmen, van Loon, Tim, Cramer, Maarten J, Teske, Arco J, Delhaas, Tammo, Huberts, Wouter, Lumens, Joost

“…Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease, clinically characterized by life-threatening ventricular arrhythmias and progressive…”
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Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model by van Osta, Nick, Lyon, Aurore, Kirkels, Feddo, Koopsen, Tijmen, van Loon, Tim, Cramer, Maarten J., Teske, Arco J., Delhaas, Tammo, Huberts, Wouter, Lumens, Joost

“…Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease, clinically characterized by life-threatening ventricular arrhythmias and progressive…”
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Increased Chamber Resting Tone Is a Key Determinant of Left Ventricular Diastolic Dysfunction by Tamargo, María, Martínez-Legazpi, Pablo, Espinosa, M Ángeles, Lyon, Aurore, Méndez, Irene, Gutiérrez-Ibañes, Enrique, Fernández, Ana I, Prieto-Arévalo, Raquel, González-Mansilla, Ana, Arts, Theo, Delhaas, Tammo, Mombiela, Teresa, Sanz-Ruiz, Ricardo, Elízaga, Jaime, Yotti, Raquel, Tschöpe, Carsten, Fernández-Avilés, Francisco, Lumens, Joost, Bermejo, Javier

“…Twitch-independent tension has been demonstrated in cardiomyocytes, but its role in heart failure (HF) is unclear. We aimed to address twitch-independent…”
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Understanding the effects of heart beat irregularity on ventricular function in human atrial fibrillation: simulation models may help to untie the knot—Authors’ reply by Lyon, Aurore, van Mourik, Manouk, Cruts, Laura, Heijman, Jordi, Bekkers, Sebastiaan C A M, Schotten, Ulrich, Crijns, Harry J G M, Linz, Dominik, Lumens, Joost

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The prognostic impact of mechanical atrial dysfunction and atrial fibrillation in heart failure with preserved ejection fraction by Weerts, Jerremy, Barandiarán Aizpurua, Arantxa, Henkens, Michiel T H M, Lyon, Aurore, van Mourik, Manouk J W, van Gemert, Mathijs R A A, Raafs, Anne, Sanders-van Wijk, Sandra, Bayés-Genís, Antoni, Heymans, Stephane R B, Crijns, Harry J G M, Brunner-La Rocca, Hans-Peter, Lumens, Joost, van Empel, Vanessa P M, Knackstedt, Christian

“…Abstract Aims This study assessed the prognostic implications of mechanical atrial dysfunction in heart failure with preserved ejection fraction (HFpEF)…”
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Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK by van Mourik, Manouk J.W., Artola Arita, Vicente, Lyon, Aurore, Lumens, Joost, De With, Ruben R., van Melle, Joost P., Schotten, Ulrich, Bekkers, Sebastiaan C.A.M., Crijns, Harry J.G.M., Van Gelder, Isabelle C., Rienstra, Michiel, Linz, Dominik K.

“…To identify the association between comorbidities and left atrial (LA) and right atrial (RA) function in patients with paroxysmal atrial fibrillation (AF)…”
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