Search Results - "Lynn Fink, J."

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity by Liu, Longqi, Liu, Chuanyu, Quintero, Andrés, Wu, Liang, Yuan, Yue, Wang, Mingyue, Cheng, Mengnan, Leng, Lizhi, Xu, Liqin, Dong, Guoyi, Li, Rui, Liu, Yang, Wei, Xiaoyu, Xu, Jiangshan, Chen, Xiaowei, Lu, Haorong, Chen, Dongsheng, Wang, Quanlei, Zhou, Qing, Lin, Xinxin, Li, Guibo, Liu, Shiping, Wang, Qi, Wang, Hongru, Fink, J. Lynn, Gao, Zhengliang, Liu, Xin, Hou, Yong, Zhu, Shida, Yang, Huanming, Ye, Yunming, Lin, Ge, Chen, Fang, Herrmann, Carl, Eils, Roland, Shang, Zhouchun, Xu, Xun

“…Integrative analysis of multi-omics layers at single cell level is critical for accurate dissection of cell-to-cell variation within certain cell populations…”
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Chromosome arm aneuploidies shape tumour evolution and drug response by Shukla, Ankit, Nguyen, Thu H. M., Moka, Sarat B., Ellis, Jonathan J., Grady, John P., Oey, Harald, Cristino, Alexandre S., Khanna, Kum Kum, Kroese, Dirk P., Krause, Lutz, Dray, Eloise, Fink, J. Lynn, Duijf, Pascal H. G.

“…Chromosome arm aneuploidies (CAAs) are pervasive in cancers. However, how they affect cancer development, prognosis and treatment remains largely unknown…”
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Targeted Next-Generation Sequencing for Detecting MLL Gene Fusions in Leukemia by Afrin, Sadia, Zhang, Christine R C, Meyer, Claus, Stinson, Caedyn L, Pham, Thy, Bruxner, Timothy J C, Venn, Nicola C, Trahair, Toby N, Sutton, Rosemary, Marschalek, Rolf, Fink, J Lynn, Moore, Andrew S

“…Mixed lineage leukemia ( ) gene rearrangements characterize approximately 70% of infant and 10% of adult and therapy-related leukemia. Conventional clinical…”
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LOCATE: a mammalian protein subcellular localization database by Sprenger, Josefine, Lynn Fink, J, Karunaratne, Seetha, Hanson, Kelly, Hamilton, Nicholas A, Teasdale, Rohan D

“…LOCATE is a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of mouse and human proteins…”
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PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors by Smith, Amanda M, Zhang, Christine R C, Cristino, Alexandre S, Grady, John P, Fink, J Lynn, Moore, Andrew S

“…Kinases such as MEK are attractive targets for novel therapy in cancer, including acute myeloid leukaemia (AML). Acquired and inherent resistance to kinase…”
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Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors by Roy, Edwige, Wong, Ho Yi, Villani, Rehan, Rouille, Thomas, Salik, Basit, Sim, Seen Ling, Murigneux, Valentine, Stark, Mitchell S., Fink, J. Lynn, Soyer, H. Peter, Walker, Graeme, Lyons, J. Guy, Saunders, Nicholas, Khosrotehrani, Kiarash

“…To better understand the influence of ultraviolet (UV) irradiation on the initial steps of skin carcinogenesis, we examine patches of labeled keratinocytes as…”
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Marked mitochondrial genetic variation in individuals and populations of the carcinogenic liver fluke Clonorchis sinensis by Kinkar, Liina, Korhonen, Pasi K, Wang, Daxi, Zhu, Xing-Quan, Chelomina, Galina N, Wang, Tao, Hall, Ross S, Koehler, Anson V, Harliwong, Ivon, Yang, Bicheng, Fink, J. Lynn, Young, Neil D, Gasser, Robin B

“…Clonorchiasis is a neglected tropical disease caused by the Chinese liver fluke, Clonorchis sinensis, and is often associated with a malignant form of bile…”
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Erythrocyte microRNA sequencing reveals differential expression in relapsing-remitting multiple sclerosis by Groen, Kira, Maltby, Vicki E, Lea, Rodney A, Sanders, Katherine A, Fink, J Lynn, Scott, Rodney J, Tajouri, Lotti, Lechner-Scott, Jeannette

“…There is a paucity of knowledge concerning erythrocytes in the aetiology of Multiple Sclerosis (MS) despite their potential to contribute to disease through…”
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Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric Chromosomes by Lin, Cheng-Yu, Shukla, Ankit, Grady, John P, Fink, J Lynn, Dray, Eloise, Duijf, Pascal H G

“…Chromosomal translocations drive the development of many hematological and some solid cancers. Several factors have been identified to explain the non-random…”
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Evaluation and comparison of mammalian subcellular localization prediction methods by Sprenger, Josefine, Fink, J Lynn, Teasdale, Rohan D

“…Determination of the subcellular location of a protein is essential to understanding its biochemical function. This information can provide insight into the…”
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LOCATE: a mouse protein subcellular localization database by Fink, J. Lynn, Aturaliya, Rajith N, Davis, Melissa J, Zhang, Fasheng, Hanson, Kelly, Teasdale, Melvena S, Kai, Chikatoshi, Kawai, Jun, Carninci, Piero, Hayashizaki, Yoshihide, Teasdale, Rohan D

“…We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from…”
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Computational biology resources lack persistence and usability by Veretnik, Stella, Fink, J Lynn, Bourne, Philip E

“…  Web Server Persistence To evaluate the persistence of biology Web servers, we extracted all the URLs from the Nucleic Acids Research (NAR) Web server issues…”
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A workflow to increase verification rate of chromosomal structural rearrangements using high-throughput next-generation sequencing by Quek, Kelly, Nones, Katia, Patch, Ann-Marie, Fink, J Lynn, Newell, Felicity, Cloonan, Nicole, Miller, David, Fadlullah, Muhammad Z H, Kassahn, Karin, Christ, Angelika N, Bruxner, Timothy J C, Manning, Suzanne, Harliwong, Ivon, Idrisoglu, Senel, Nourse, Craig, Nourbakhsh, Ehsan, Wani, Shivangi, Steptoe, Anita, Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Taylor, Darrin, Wood, Scott, Xu, Qinying, Wilson, Peter, Biankin, Andrew V, Pearson, John V, Waddell, Nic, Grimmond, Sean M

“…Somatic rearrangements, which are commonly found in human cancer genomes, contribute to the progression and maintenance of cancers. Conventionally, the…”
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Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability by Dutta, Ankit K., Fink, J. Lynn, Grady, John P., Morgan, Gareth J., Mullighan, Charles G., To, Luen B., Hewett, Duncan R., Zannettino, Andrew C. W.

“…Multiple myeloma (MM) is a largely incurable haematological malignancy defined by the clonal proliferation of malignant plasma cells (PCs) within the bone…”
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Use of keyword hierarchies to interpret gene expression patterns by Masys, Daniel R., Welsh, John B., Lynn Fink, J., Gribskov, Michael, Klacansky, Igor, Corbeil, Jacques

“…Motivation: High-density microarray technology permits the quantitative and simultaneous monitoring of thousands of genes. The interpretation challenge is to…”
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Progression of Disease Within 24 Months in Follicular Lymphoma Is Associated With Reduced Intratumoral Immune Infiltration by Tobin, Joshua W D, Keane, Colm, Gunawardana, Jay, Mollee, Peter, Birch, Simone, Hoang, Thanh, Lee, Justina, Li, Li, Huang, Li, Murigneux, Valentine, Fink, J Lynn, Matigian, Nicholas, Vari, Frank, Francis, Santiyagu, Kridel, Robert, Weigert, Oliver, Haebe, Sarah, Jurinovic, Vindi, Klapper, Wolfram, Steidl, Christian, Sehn, Laurie H, Law, Soi-Cheng, Wykes, Michelle N, Gandhi, Maher K

“…Understanding the immunobiology of the 15% to 30% of patients with follicular lymphoma (FL) who experience progression of disease within 24 months (POD24)…”
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Word add-in for ontology recognition: semantic enrichment of scientific literature by Fink, J Lynn, Fernicola, Pablo, Chandran, Rahul, Parastatidis, Savas, Wade, Alex, Naim, Oscar, Quinn, Gregory B, Bourne, Philip E

“…In the current era of scientific research, efficient communication of information is paramount. As such, the nature of scholarly and scientific communication…”
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I am not a scientist, I am a number by Bourne, Philip E, Fink, J Lynn

“…  In so doing, they create a profile for themselves, which is in a standard format and can be exported and shared by many other sites, provided the owner…”
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Differential use of signal peptides and membrane domains is a common occurrence in the protein output of transcriptional units by Davis, Melissa J, Hanson, Kelly A, Clark, Francis, Fink, J Lynn, Zhang, Fasheng, Kasukawa, Takeya, Kai, Chikatoshi, Kawai, Jun, Carninci, Piero, Hayashizaki, Yoshihide, Teasdale, Rohan D

“…Membrane organization describes the orientation of a protein with respect to the membrane and can be determined by the presence, or absence, and organization…”
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Open access: taking full advantage of the content by Bourne, Philip E, Fink, J Lynn, Gerstein, Mark

“…  [...]there are no "killer apps." Since this readership, beyond any other, would seem to have the ability to change this situation at least in the…”
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